\nHydroa vacciniforme is a rare photodermatosis that usually presents in childhood as vesicles<\/span> that heal with scars. Although he Pathogenesis<\/span> is not well understood, Epstein Barr virus (EBV) can be detected in the dermal<\/span> infiltrate<\/span>. It is currently unclear whether hydroa vacciniforme T cell<\/span> lymphoma<\/span> is a discreet<\/span> entity or is at the severe end of the hydroa vacciniforme spectrum.<\/p>\n<\/span>\nHistology<\/span> of hydroa vacciniforme<\/span><\/h2>\nIn hydroa vacciniforme, the sections show epidermal<\/span> spongiosis<\/span>, vesiculation and necrosis<\/span> superimposed on a dense dermal infiltrate (figure 1). Necrosis can be confluent<\/span> (figures 2, 3) and infiltrated by a mixture of acute<\/span> and chronic<\/span> inflammatory<\/span> cells. In older injuries there may be scarring.<\/p>\nFigure 4 shows the denser infiltrate seen in hydroa vacciniforme-type T-cell lymphoma, which may have identical epidermal\/superficial changes.<\/p>\n\n<\/span>Hydroa vacciniform pathology<\/span><\/h5>\n<\/section>\n\n\n
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Figure 1<\/p>\n
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Figure 2<\/p>\n
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figure 3<\/p>\n
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Figure 4<\/p>\n<\/p><\/div>\n<\/section>\n
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<\/span>Special studies for hydroa vacciniforme<\/span><\/h2>\nEBV can be detected in the dermal infiltrate (with in the place<\/span> hybridization for EBER).<\/p>\n\n
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<\/span>\nDifferential diagnosis<\/span> of hydroa vacciniforme<\/span><\/h2>\nVacciniform hydroa T-cell lymphoma: It is currently unclear whether this is a discrete entity or whether it falls within the vacciniform hydroa spectrum. With this lymphoma, the lesions are usually larger, do not resolve, and may also involve sites not exposed to the sun. The infiltrator in the dermis<\/span> may be denser than seen in hydroa vacciniforme and the subcutaneous<\/span> fat can be infiltrated (figure 4). Immunohistochemical studies reveal that the infiltrate is composed of CD3+. CD8+, TIA+ T cells<\/span> or CD56+ NK cells<\/span>. Gene<\/span> Rearrangement studies may be positive. EBV in situ hybridization may be positive in the infiltrate.<\/p>\n<\/section>","protected":false},"excerpt":{"rendered":"Hydroa vacciniforme is a rare photodermatosis that usually presents in childhood as vesicles that heal with scars. Although the pathogenesis is not well understood, the Epstein Barr virus\u2026<\/p>","protected":false},"author":8,"featured_media":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","format":"standard","meta":{"footnotes":""},"categories":[204],"tags":[205],"class_list":["post-11806","wiki","type-wiki","status-publish","format-standard","category-glosario-definiciones","tag-patologia"],"_links":{"self":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/11806","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki"}],"about":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/types\/wiki"}],"author":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/comments?post=11806"}],"version-history":[{"count":0,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/11806\/revisions"}],"wp:attachment":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/media?parent=11806"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/categories?post=11806"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/tags?post=11806"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}