<\/span><\/h2>\nKyrle's disease was first described in 1916 by Kyrle as 'hyperkeratosis<\/span> follicular and follicular in the body penetrating and identified as a perforating disease. To this day, controversy remains over the classification of Kyrle's disease: is it a distinct disease entity, part of the acquired perforation spectrum? skin disease<\/span> or a subtype of acquired perforating collagenosis?<\/p>\nCurrently, two major perforating diseases include reactive perforating collagenosis and elastosis<\/span> perforans serpiginosa. In some literature, acquired perforating dermatosis is a third major group and is a general term for cases of perforating disease arising in adults, usually associated with a systemic<\/span> disease.<\/p>\nKyrle's disease is characterized by the formation of large papules<\/span> with central curb<\/span> plugs and is often associated with hepatic<\/span>, renal<\/span> or diabetic disorders. It can affect men and women throughout life, although the average age at presentation is 30 years.<\/p>\n<\/span>What causes Kyrle disease?<\/span><\/h2>\nThe cause of the disease is unknown. Some cases seem to be idiopathic<\/span> (no known triggers), or inherited. What has been found is that Kyrle disease appears to occur more frequently in patients with certain systemic disorders, these include:<\/p>\n\n- Mellitus diabetes<\/li>\n
- Renal disease (chronic<\/span> kidney failure, albuminuria, elevated serum<\/span> creatinine, abnormal creatinine clearance, polyuria)<\/li>\n
- Liver abnormalities (alcoholic cirrhosis<\/span>)<\/li>\n
- Congestive heart failure<\/li>\n<\/ul>\n
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<\/span>What are the signs and symptoms?<\/span><\/h2>\nThe lesions begin as small papules with silvery scales that eventually grow to approximately 1.5 cm in diameter to form red-brown. nodules<\/span> with central keratin plug (cornea). Multiple injuries can get together<\/span> to form large keratotic<\/span> plates<\/span>. Lesions occur primarily on the legs, but also develop on the arms and the head and neck region. Palms and soles are rarely affected. Without treatment, lesions heal spontaneously, but new ones continue to develop.<\/p>\nThe lesions are not painful, but patients may experience intense pruritus<\/span> (itch).<\/p>\n\n<\/span>Kyrle's disease<\/span><\/h5>\n<\/section>\n\n\n
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Kyrle's disease<\/p>\n
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Kyrle's disease<\/p>\n
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Kyrle's disease<\/p>\n<\/p><\/div>\n<\/section>\n
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<\/span>How was the diagnosis made?<\/span><\/h2>\nThere are many other disorders characterized by papules or nodules with central keratotic plugs and crusts. The deep penetration of keratotic plugs, the size and irregularity, the age of appearance and the distribution<\/span> of the lesions should help in the diagnosis. It is also essential to examine and evaluate any underlying conditions, such as diabetes, liver and kidney disease.<\/p>\nThe diagnosis is confirmed by histopathology<\/span> of a skin biopsy<\/span>, showing incomplete keratinization<\/span> and a hyperkeratotic<\/span>, parakeratotic<\/span> plug. <\/p>\n<\/span>What treatment is available?<\/span><\/h2>\nThe goal of treatment should be to treat the underlying disease if associated. Rapid improvement and resolution of lesions are often seen once the underlying disease is treated.<\/p>\n
The lesions may heal on their own without any treatment, but new lesions often develop. Treatments that have been used to treat and reduce injuries include:<\/p>\n
\n- Isotretinoin<\/li>\n
- High doses of vitamin A<\/li>\n
- Tretinoin cream<\/span><\/li>\n<\/ul>\n
Emollients<\/span> and oral antihistamines are useful in relieving pruritus.<\/p>\n<\/section>","protected":false},"excerpt":{"rendered":"\u00bfQu\u00e9 es la enfermedad de Kyrle? La enfermedad de Kyrle fue descrita por primera vez en 1916 por Kyrle como \u2018hiperqueratosis folicular y folicular en el cuerpo penetrante e identificado…<\/p>","protected":false},"author":8,"featured_media":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-13243","wiki","type-wiki","status-publish","format-standard"],"_links":{"self":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/13243","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki"}],"about":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/types\/wiki"}],"author":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/comments?post=13243"}],"version-history":[{"count":0,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/13243\/revisions"}],"wp:attachment":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/media?parent=13243"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/categories?post=13243"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/tags?post=13243"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}