{"id":16485,"date":"2020-04-28T12:17:54","date_gmt":"2020-04-28T15:17:54","guid":{"rendered":"https:\/\/doctorhoogstra.com\/es\/wiki\/deficiencia-especifica-de-anticuerpos\/"},"modified":"2020-04-28T12:17:54","modified_gmt":"2020-04-28T15:17:54","slug":"specific-antibody-deficiency","status":"publish","type":"wiki","link":"https:\/\/doctorhoogstra.com\/en\/wiki\/deficiencia-especifica-de-anticuerpos\/","title":{"rendered":"Specific antibody deficiency"},"content":{"rendered":"<p><\/p><div id=\"ez-toc-container\" class=\"ez-toc-v2_0_88 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 eztoc-toggle-hide-by-default' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/deficiencia-especifica-de-anticuerpos\/#Lo-que-es-especifico-anticuerpo-%C2%BFdeficiencia\" >What is specific antibody deficiency?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/deficiencia-especifica-de-anticuerpos\/#%C2%BFQuien-contrae-deficiencia-especifica-de-anticuerpos\" >Who gets specific antibody deficiency?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/deficiencia-especifica-de-anticuerpos\/#%C2%BFQue-causa-la-deficiencia-especifica-de-anticuerpos\" >What causes specific antibody deficiency?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/deficiencia-especifica-de-anticuerpos\/#%C2%BFCuales-son-los-signos-y-sintomas-de-la-deficiencia-especifica-de-anticuerpos\" >What are the signs and symptoms of specific antibody deficiency?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/deficiencia-especifica-de-anticuerpos\/#%C2%BFComo-se-diagnostica-la-deficiencia-especifica-de-anticuerpos\" >How is specific antibody deficiency diagnosed?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/deficiencia-especifica-de-anticuerpos\/#%C2%BFComo-se-trata-la-deficiencia-especifica-de-anticuerpos\" >How is specific antibody deficiency treated?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/deficiencia-especifica-de-anticuerpos\/#Cual-es-el-pronostico-para-la-deficiencia-especifica-de-anticuerpos\" >What is the prognosis for specific antibody deficiency?<\/a><\/li><\/ul><\/nav><\/div>\n\n<section class=\"textBlock\">\n<h2><span class=\"ez-toc-section\" id=\"Lo-que-es-especifico-anticuerpo-%C2%BFdeficiencia\"><\/span>What is specific <span class=\"term\" data-term-id=\"425\">antibody<\/span> deficiency?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>A patient with a specific antibody deficiency cannot produce IgG <span class=\"term\" data-term-id=\"1853\">molecules<\/span> to the polysaccharides in <span class=\"term\" data-term-id=\"1705\">encapsulated<\/span> <span class=\"term\" data-term-id=\"935\">bacteria<\/span> (as <em>steotococci pneumonia<\/em>, <em>Staphylococcus aureus<\/em>and <em>Haemophilus influenzae<\/em>) This makes the patient vulnerable to <span class=\"term\" data-term-id=\"805\">recurrent<\/span> <span class=\"term\" data-term-id=\"937\">bacterial<\/span> lung infections (pneumonia), <span class=\"term\" data-term-id=\"267\">breast<\/span> infections, ear infections (<span class=\"term\" data-term-id=\"1866\">otitis media<\/span>), and others.<\/p>\n<p>Specific antibody deficiency is also called selective antibody deficiency, partial antibody deficiency, and impairment <span class=\"term\" data-term-id=\"1864\">polysaccharide<\/span> sensitivity.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%C2%BFQuien-contrae-deficiencia-especifica-de-anticuerpos\"><\/span>Who gets specific antibody deficiency?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Specific antibody deficiency is usually diagnosed in preschool-age children and occurs in both girls and boys of all races.<\/p>\n<div id=\"square-placement-country-holder\" class=\"country-dependent advert\">\n<div class=\"box-placement square-placement\">\n<div class=\"advert__frame\">\n<div id=\"dermnet-dermnet-mobbox\">\n<\/div><\/div><\/div><\/div>\n<h2><span class=\"ez-toc-section\" id=\"%C2%BFQue-causa-la-deficiencia-especifica-de-anticuerpos\"><\/span>What causes specific antibody deficiency?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The exact cause of specific antibody deficiency is unknown, but it is likely due to a <span class=\"term\" data-term-id=\"558\">genetic<\/span> <span class=\"term\" data-term-id=\"870\">mutation<\/span>. This may be due to a communication failure between <span class=\"term\" data-term-id=\"430\">B cells<\/span> and other cells in the immune system.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%C2%BFCuales-son-los-signos-y-sintomas-de-la-deficiencia-especifica-de-anticuerpos\"><\/span>What are the signs and symptoms of specific antibody deficiency?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Some patients with specific antibody deficiency are <span class=\"term\" data-term-id=\"731\">asymptomatic<\/span> because other components of your immune system remain functional. Other patients may present:<\/p>\n<ul>\n<li>Otitis media, sinusitis, bronchitis, pneumonia and other bacterial infections.<\/li>\n<li>\n<p>Infections that are not as serious as severe combined immunodeficiency or x-related agammaglobulinemia\n<\/li>\n<li>\n<span class=\"term\" data-term-id=\"922\">Atopic<\/span> <span class=\"term\" data-term-id=\"491\">eczema<\/span> and asthma (affecting 50% in patients with specific antibody deficiency)<\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"%C2%BFComo-se-diagnostica-la-deficiencia-especifica-de-anticuerpos\"><\/span>How is specific antibody deficiency diagnosed?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The diagnosis of specific antibody deficiency is based on:<\/p>\n<ul>\n<li>Normal T and B levels <span class=\"term\" data-term-id=\"421\">lymphocytes<\/span>\n<\/li>\n<li>Normal levels of <span class=\"term\" data-term-id=\"428\">immunoglobulins<\/span> including IgG subclasses<\/li>\n<li>Absence of another detectable immunodeficiency disease (including human immunodeficiency virus <span class=\"term\" data-term-id=\"145\">infection<\/span>, <span class=\"term\" data-term-id=\"127\">HIV<\/span>)<\/li>\n<li>History of recurrent respiratory infections.<\/li>\n<li>Administer the standard pneumococcal vaccine and then find lack of antibody formation after 4 to 6 weeks.<\/li>\n<\/ul>\n<div id=\"square-placement-country-holder\" class=\"country-dependent advert\">\n<div class=\"box-placement square-placement\">\n<div class=\"advert__frame\">\n<div id=\"dermnet-dermnet-mobbox\">\n<\/div><\/div><\/div><\/div>\n<h2><span class=\"ez-toc-section\" id=\"%C2%BFComo-se-trata-la-deficiencia-especifica-de-anticuerpos\"><\/span>How is specific antibody deficiency treated?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Treatment for specific antibody deficiency focuses on:<\/p>\n<ul>\n<li>Infection <span class=\"term\" data-term-id=\"1854\">control<\/span> with antibiotics in high doses for ten days or daily for <span class=\"term\" data-term-id=\"1737\">prophylaxis<\/span> against infection<\/li>\n<li>\n<span class=\"term\" data-term-id=\"427\">Immunoglobulin<\/span> replacement therapy administered intravenously or subcutaneously if indicated<\/li>\n<li>Stimulating a better immune response to vaccination by using a heptavalent or 13-valent pneumococcal polysaccharide vaccine <span class=\"term\" data-term-id=\"472\">conjugate<\/span> with protein and HIB, an anti-Haemophilus vaccine.<\/li>\n<\/ul>\n<p><span class=\"term\" data-term-id=\"949\">Primary<\/span> The goals of treatment are to prevent bronchiectasis and lung scarring from repeated respiratory infections and to maintain overall quality of life.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Cual-es-el-pronostico-para-la-deficiencia-especifica-de-anticuerpos\"><\/span>Which is the <span class=\"term\" data-term-id=\"241\">forecast<\/span> for specific antibody deficiency?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The prognosis for patients with specific antibody deficiency is generally reasonable. Children are known to naturally overcome specific antibody deficiency and those who do not can still maintain a good quality of life with antibiotic and immunoglobulin therapy.<\/p>\n<\/section>","protected":false},"excerpt":{"rendered":"<p>Lo que es espec\u00edfico anticuerpo \u00bfdeficiencia? Un paciente con una deficiencia espec\u00edfica de anticuerpos no puede producir IgG mol\u00e9culas a los polisac\u00e1ridos en encapsulado bacterias (como steotococos neumonia, Staphylococcus aureusy&#8230;<\/p>","protected":false},"author":8,"featured_media":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-16485","wiki","type-wiki","status-publish","format-standard"],"_links":{"self":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/16485","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki"}],"about":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/types\/wiki"}],"author":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/comments?post=16485"}],"version-history":[{"count":0,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/16485\/revisions"}],"wp:attachment":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/media?parent=16485"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/categories?post=16485"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/tags?post=16485"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}