{"id":16543,"date":"2020-04-28T17:49:23","date_gmt":"2020-04-28T20:49:23","guid":{"rendered":"https:\/\/doctorhoogstra.com\/es\/wiki\/patologia-del-sarcoma-de-kaposi\/"},"modified":"2020-04-30T21:27:23","modified_gmt":"2020-05-01T00:27:23","slug":"pathology-of-kaposi-sarcoma-2","status":"publish","type":"wiki","link":"https:\/\/doctorhoogstra.com\/en\/wiki\/patologia-del-sarcoma-de-kaposi\/","title":{"rendered":"Kaposi&#039;s sarcoma pathology"},"content":{"rendered":"<p><\/p><div id=\"ez-toc-container\" class=\"ez-toc-v2_0_88 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 eztoc-toggle-hide-by-default' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/patologia-del-sarcoma-de-kaposi\/#Introduccion\" >Introduction<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/patologia-del-sarcoma-de-kaposi\/#Histologia-del-sarcoma-de-Kaposi\" >Kaposi&#039;s sarcoma histology<\/a><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/patologia-del-sarcoma-de-kaposi\/#Patologia-del-sarcoma-de-Kaposi\" >Kaposi&#039;s sarcoma pathology<\/a><\/li><\/ul><\/li><\/ul><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/patologia-del-sarcoma-de-kaposi\/#Histologico-variantes-del-sarcoma-de-Kaposi\" >Histological variants of Kaposi&#039;s sarcoma<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/patologia-del-sarcoma-de-kaposi\/#Pruebas-especiales-en-el-sarcoma-de-Kaposi\" >Special tests for Kaposi&#039;s sarcoma.<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/patologia-del-sarcoma-de-kaposi\/#Diagnostico-diferencial-del-sarcoma-de-Kaposi\" >Differential diagnosis of Kaposi&#039;s sarcoma<\/a><\/li><\/ul><\/nav><\/div>\n\n<section class=\"textBlock\">\n<h2><span class=\"ez-toc-section\" id=\"Introduccion\"><\/span>Introduction<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Kaposi <span class=\"term\" data-term-id=\"1665\">sarcoma<\/span> it is <span class=\"term\" data-term-id=\"116\">grouped<\/span> inside <span class=\"term\" data-term-id=\"753\">vascular<\/span> variable tumors <span class=\"term\" data-term-id=\"176\">evil one<\/span> behavior. the <span class=\"term\" data-term-id=\"128\">histology<\/span> It is typically very distinctive. The characteristics change depending on the nature of the <span class=\"term\" data-term-id=\"164\">injury<\/span> clinically as you progress from <span class=\"term\" data-term-id=\"224\">patch<\/span> to <span class=\"term\" data-term-id=\"235\">license plate<\/span> to <span class=\"term\" data-term-id=\"733\">nodular<\/span> phase.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Histologia-del-sarcoma-de-Kaposi\"><\/span>Kaposi&#039;s sarcoma histology<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The low-power view of Kaposi&#039;s sarcoma histology is of a <span class=\"term\" data-term-id=\"956\">cellular<\/span> <span class=\"term\" data-term-id=\"52\">dermal<\/span> <span class=\"term\" data-term-id=\"198\">nodule<\/span> (Figure 1). There may be varying degrees of overlap <span class=\"term\" data-term-id=\"846\">epidermal<\/span> changes that can range from prominent <span class=\"term\" data-term-id=\"610\">hyperkeratosis<\/span> and <span class=\"term\" data-term-id=\"2\">acanthosis<\/span> Frank <span class=\"term\" data-term-id=\"1278\">ulceration<\/span>. The dermal <span class=\"term\" data-term-id=\"893\">proliferation<\/span> is composed of a <span class=\"term\" data-term-id=\"1659\">spindle cell<\/span> proliferation of <span class=\"term\" data-term-id=\"758\">endothelial<\/span> cells that form sinuous vascular spaces. These may be rare in patch phase lesions, progressing to <span class=\"term\" data-term-id=\"1674\">fascicles<\/span> of <span class=\"term\" data-term-id=\"1660\">spindle cells<\/span> in nodular lesions (Figures 2,3). This fascicular pattern has been compared to schools of fish. Spindle cells <span class=\"term\" data-term-id=\"541\">infiltrate<\/span> through <span class=\"term\" data-term-id=\"39\">collagen<\/span>, forming slit-shaped spaces, especially towards the periphery of the lesions (Figure 4). Where newly formed vessels project into an existing space, the promontory <span class=\"term\" data-term-id=\"899\">sign<\/span> is seen (Figure 5). This is now recognized as non-specific to this condition.<\/p>\n<p>In plaque and nodular stage lesions, there may be visible <span class=\"term\" data-term-id=\"1684\">intracellular<\/span> and extracellular <span class=\"term\" data-term-id=\"1602\">hyaline<\/span> globules, though to represent engulfed <span class=\"term\" data-term-id=\"696\">erythrocytes<\/span>. Although rare, this can be seen in patch-stage lesions. They stain PAS positive. While endothelial proliferation is common <span class=\"term\" data-term-id=\"325\">monomorphic<\/span>, can be significant <span class=\"term\" data-term-id=\"1612\">nuclear<\/span> <span class=\"term\" data-term-id=\"1305\">atypia<\/span> with more <span class=\"term\" data-term-id=\"1536\">mitotic<\/span> activity (Figure 6). When prominent atypia is seen <span class=\"term\" data-term-id=\"289\">tumor<\/span> fits into the category of a <span class=\"term\" data-term-id=\"1327\">anaplastic<\/span> variant.<\/p>\n<p>the <span class=\"term\" data-term-id=\"490\">inflammatory<\/span> the infiltrator is predominantly <span class=\"term\" data-term-id=\"422\">lymphocytic<\/span> with scattered <span class=\"term\" data-term-id=\"1513\">plasma<\/span> Cells are also a clue to this diagnosis. Red blood cells are seen within the slit-shaped spaces and throughout the tumor. Sometimes at the base and periphery of nodular Kaposi, there may be large cavernous vessels.<\/p>\n<section class=\"textBlock imageLinkBlockTitle\">\n<h5 class=\"colour--primary\"><span class=\"ez-toc-section\" id=\"Patologia-del-sarcoma-de-Kaposi\"><\/span>Kaposi&#039;s sarcoma pathology<span class=\"ez-toc-section-end\"><\/span><\/h5>\n<\/section>\n<section class=\"imageLinkBlock\">\n<div class=\"flex\">\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='kaposisfigure1__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisinkildbd-7250901-9416101' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/KaposisFigure1__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsInkiLDBd-7250901.jpg'>\n<\/div>\n<p class=\"p-small\">Figure 1<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='kaposisfigure2__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-5734811-9409644' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/KaposisFigure2__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-5734811.jpg'>\n<\/div>\n<p class=\"p-small\">Figure 2<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='kaposisfigure3__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-6189025-5118940' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/KaposisFigure3__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-6189025.jpg'>\n<\/div>\n<p class=\"p-small\">figure 3<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='kaposisfigure5__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-8589958-3226545' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/KaposisFigure5__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-8589958.jpg'>\n<\/div>\n<p class=\"p-small\">Figure 4<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='kaposisfigure6__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-5660565-9674462' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/KaposisFigure6__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-5660565.jpg'>\n<\/div>\n<p class=\"p-small\">Figure 5<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='kaposisfigure7__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-9905460-5424057' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/KaposisFigure7__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-9905460.jpg'>\n<\/div>\n<p class=\"p-small\">Figure 6<\/p>\n<\/p><\/div>\n<\/section>\n<div class=\"clearfix imageLinkBlock\"><\/div>\n<div id=\"square-placement-country-holder\" class=\"country-dependent advert\">\n<div class=\"box-placement square-placement\">\n<div class=\"advert__frame\">\n<div id=\"dermnet-dermnet-mobbox\">\n<\/div><\/div><\/div><\/div>\n<h2><span class=\"ez-toc-section\" id=\"Histologico-variantes-del-sarcoma-de-Kaposi\"><\/span>\n<span class=\"term\" data-term-id=\"474\">Histological<\/span> variants of Kaposi&#039;s sarcoma<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Numerous pathological variations have been described for Kaposi&#039;s sarcoma depending on the nature of the associated additional features or the pattern of dermal proliferation. They are largely intuitive in describing the injury. Reported variants include:<\/p>\n<ul>\n<li>Anaplastic<\/li>\n<li>Telangiectatic<\/li>\n<li>Lymphedematous<\/li>\n<li><span class=\"term\" data-term-id=\"1470\">Hyperkeratotic<\/span><\/li>\n<li>Cheloidal<\/li>\n<li>Micronodular<\/li>\n<li>\n<span class=\"term\" data-term-id=\"254\">Pyogenic<\/span> <span class=\"term\" data-term-id=\"113\">granuloma<\/span>-I like it<\/li>\n<li>Ecchemotic<\/li>\n<li><span class=\"term\" data-term-id=\"1162\">Intravascular<\/span><\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"Pruebas-especiales-en-el-sarcoma-de-Kaposi\"><\/span>Special tests for Kaposi&#039;s sarcoma.<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Lesion cells in Kaposi&#039;s sarcoma are positive for the non-specific endothelial markers CD31 (Figure 7) and CD34, and also for the <span class=\"term\" data-term-id=\"744\">lymphatic<\/span> endothelial marker D2-40 or podoplanin. the <span class=\"term\" data-term-id=\"425\">antibody<\/span> a HHV-8 (Human herpes virus 8) <span class=\"term\" data-term-id=\"1040\">latent<\/span> nuclear <span class=\"term\" data-term-id=\"410\">antigen<\/span> 1 is a highly specific commercial stain and has simplified diagnosis in difficult cases. Figure 8.<\/p>\n<section class=\"imageLinkBlock\">\n<div class=\"flex\">\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='kaposisfigure8cd31__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-3104040-1436221' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/KaposisFigure8CD31__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-3104040.jpg'>\n<\/div>\n<p class=\"p-small\">Figure 7<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='kaposisfigure9hhv8__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-9697596-6550583' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/KaposisFigure9HHV8__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-9697596.jpg'>\n<\/div>\n<p class=\"p-small\">Figure 8<\/p>\n<\/p><\/div>\n<\/section>\n<div class=\"clearfix imageLinkBlock\"><\/div>\n<h2><span class=\"ez-toc-section\" id=\"Diagnostico-diferencial-del-sarcoma-de-Kaposi\"><\/span>\n<span class=\"term\" data-term-id=\"813\">Differential diagnosis<\/span> Kaposi&#039;s sarcoma<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Microvenular <span class=\"term\" data-term-id=\"360\">hemangioma<\/span>: This vascular tumor can be difficult to distinguish clinically from early-stage patch lesions. Less well-formed ships, presence of nuclear power. <span class=\"term\" data-term-id=\"1539\">pleomorphism<\/span> and positive <span class=\"term\" data-term-id=\"1421\">immunohistochemistry<\/span> HHV-8 is compatible with Kaposi&#039;s sarcoma.<\/p>\n<p>Tufted hemangioma: Multiple lobes of spindle cells are seen, but they lack the interlocking pattern of Kaposi&#039;s sarcoma or the formation of a slit-shaped vascular channel.<\/p>\n<p>Pseudo-Kaposi&#039;s sarcoma (acroangiodermatitis): While in differential from early-stage Kaposi&#039;s sarcoma, acroangiodermatitis consists of a regular proliferation of small vessels without the sinuous appearance of Kaposi&#039;s sarcoma.<\/p>\n<p>Cavernous hemangioma: This can be considered when there are dilated vessels at the base or periphery of lesions in the nodular stage, but this hemangioma lacks a spindle cell component.<\/p>\n<p>Pyogenic granuloma: Usually only a problem in partial biopsy lesions where only the superficial component of the lesion is demonstrated.<\/p>\n<\/section>","protected":false},"excerpt":{"rendered":"<p>Introducci\u00f3n Kaposi sarcoma es agrupado dentro vascular tumores de variable maligno comportamiento. los histolog\u00eda Es t\u00edpicamente muy distintivo. Las caracter\u00edsticas cambian dependiendo de la naturaleza del lesi\u00f3n cl\u00ednicamente a medida&#8230;<\/p>","protected":false},"author":8,"featured_media":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","format":"standard","meta":{"footnotes":""},"categories":[204],"tags":[205],"class_list":["post-16543","wiki","type-wiki","status-publish","format-standard","category-glosario-definiciones","tag-patologia"],"_links":{"self":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/16543","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki"}],"about":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/types\/wiki"}],"author":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/comments?post=16543"}],"version-history":[{"count":0,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/16543\/revisions"}],"wp:attachment":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/media?parent=16543"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/categories?post=16543"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/tags?post=16543"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}