{"id":16610,"date":"2020-04-28T23:54:49","date_gmt":"2020-04-29T02:54:49","guid":{"rendered":"https:\/\/doctorhoogstra.com\/es\/wiki\/patologia-de-leiomiosarcoma\/"},"modified":"2020-10-30T07:40:49","modified_gmt":"2020-10-30T10:40:49","slug":"leiomyosarcoma-pathology","status":"publish","type":"wiki","link":"https:\/\/doctorhoogstra.com\/en\/wiki\/patologia-de-leiomiosarcoma\/","title":{"rendered":"Leiomyosarcoma pathology"},"content":{"rendered":"<p><\/p><div id=\"ez-toc-container\" class=\"ez-toc-v2_0_88 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 eztoc-toggle-hide-by-default' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/patologia-de-leiomiosarcoma\/#Histologia-de-leiomiosarcoma\" >Leiomyosarcoma histology<\/a><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/patologia-de-leiomiosarcoma\/#Patologia-de-leiomiosarcoma\" >Leiomyosarcoma pathology<\/a><\/li><\/ul><\/li><\/ul><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/patologia-de-leiomiosarcoma\/#Manchas-especiales-en-leiomiosarcoma\" >Special spots in leiomyosarcoma<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/patologia-de-leiomiosarcoma\/#Histologico-variantes-de-leiomiosarcoma\" >Histological variants of leiomyosarcoma<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/patologia-de-leiomiosarcoma\/#Diagnostico-diferencial-de-leiomiosarcoma\" >Differential diagnosis of leiomyosarcoma<\/a><\/li><\/ul><\/nav><\/div>\n\n<section class=\"textBlock\">\n<p><span class=\"term\" data-term-id=\"1673\">Leiomyosarcoma<\/span> is a <span class=\"term\" data-term-id=\"176\">evil one<\/span> <span class=\"term\" data-term-id=\"289\">tumor<\/span> smooth muscle Rarely affects the skin. <\/p>\n<h2><span class=\"ez-toc-section\" id=\"Histologia-de-leiomiosarcoma\"><\/span>\n<span class=\"term\" data-term-id=\"128\">Histology<\/span> leiomyosarcoma<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The scanning power of leiomyosarcoma histology shows poor <span class=\"term\" data-term-id=\"37\">circumscribed<\/span> tumor <span class=\"term\" data-term-id=\"198\">nodule<\/span> What can be <span class=\"term\" data-term-id=\"52\">dermal<\/span> based on less common dermal leiomyosarcoma (Figure 1) or deeply infiltrating the <span class=\"term\" data-term-id=\"900\">subcutaneous<\/span> to form. The tumor is made up of a <span class=\"term\" data-term-id=\"1659\">spindle cell<\/span> <span class=\"term\" data-term-id=\"893\">proliferation<\/span> forming rough packets and <span class=\"term\" data-term-id=\"1674\">fascicles<\/span> (Figures 2 and 3). High power shows <span class=\"term\" data-term-id=\"1660\">spindle cells<\/span> shaped like a cigar <span class=\"term\" data-term-id=\"729\">nuclei<\/span> with prominent cytology <span class=\"term\" data-term-id=\"1305\">atypia<\/span> and <span class=\"term\" data-term-id=\"1536\">mitotic<\/span> figures (Figures 4 and 5).<\/p>\n<section class=\"textBlock imageLinkBlockTitle\">\n<h5 class=\"colour--primary\"><span class=\"ez-toc-section\" id=\"Patologia-de-leiomiosarcoma\"><\/span>Leiomyosarcoma pathology<span class=\"ez-toc-section-end\"><\/span><\/h5>\n<\/section>\n<section class=\"imageLinkBlock\">\n<div class=\"flex\">\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='leiomyosarcfigure1__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildc5xq-1041818-9020572' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/leiomyosarcfigure1__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDc5XQ-1041818.jpg'>\n<\/div>\n<p class=\"p-small\">Figure 1<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='leiomyosarcfigure2__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-5573934-7443883' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/leiomyosarcfigure2__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-5573934.jpg'>\n<\/div>\n<p class=\"p-small\">Figure 2<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='leiomyosarcfigure3__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-6117141-1177740' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/leiomyosarcfigure3__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-6117141.jpg'>\n<\/div>\n<p class=\"p-small\">figure 3<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='leiomyosarcfigure4__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-8577240-4966721' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/leiomyosarcfigure4__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-8577240.jpg'>\n<\/div>\n<p class=\"p-small\">Figure 4<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='leiomyosarcfigure5__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-4870260-4824626' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/leiomyosarcfigure5__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-4870260.jpg'>\n<\/div>\n<p class=\"p-small\">Figure 5<\/p>\n<\/p><\/div>\n<\/section>\n<div class=\"clearfix imageLinkBlock\"><\/div>\n<h2><span class=\"ez-toc-section\" id=\"Manchas-especiales-en-leiomiosarcoma\"><\/span>Special spots in leiomyosarcoma<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Immunoperoxidase staining is positive for muscle markers SMA (smooth muscle actin), HHF35 (pan muscle actin), h-caldesmon, and Desmin. Desmin negative staining is seen infrequently. A rare number of cases have shown <span class=\"term\" data-term-id=\"1614\">cytokeratin<\/span> or EMA (<span class=\"term\" data-term-id=\"847\">epithelial<\/span> membrane <span class=\"term\" data-term-id=\"410\">antigen<\/span>) staining.<\/p>\n<div id=\"square-placement-country-holder\" class=\"country-dependent advert\">\n<div class=\"box-placement square-placement\">\n<div class=\"advert__frame\">\n<div id=\"dermnet-dermnet-mobbox\">\n<\/div><\/div><\/div><\/div>\n<h2><span class=\"ez-toc-section\" id=\"Histologico-variantes-de-leiomiosarcoma\"><\/span>\n<span class=\"term\" data-term-id=\"474\">Histological<\/span> leiomyosarcoma variants<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span class=\"term\" data-term-id=\"1395\">Atypical<\/span> leiomyoma: this <span class=\"term\" data-term-id=\"164\">injury<\/span> it probably falls on a spectrum between leiomyoma and leiomyosarcoma. Reliable criteria to exclude <span class=\"term\" data-term-id=\"1742\">malignancy<\/span> in <span class=\"term\" data-term-id=\"47\">cutaneous<\/span> Leiomyosarcomas are missing, but reported uterine discrimination characteristics include: size less than 5.5 cm, mitotic count less than 7 per 10 high-power fields in the presence of <span class=\"term\" data-term-id=\"1612\">nuclear<\/span> atypia and lack of tumor cells <span class=\"term\" data-term-id=\"403\">necrosis<\/span>.<\/p>\n<p>Se usa un <a class=\"wpil_keyword_link\" href=\"https:\/\/drhoogstra.com.ar\/wiki\/leiomioma\/\" title=\"leiomyoma\">leiomyoma<\/a> mit\u00f3tico activo para describir una lesi\u00f3n que carece de atipia nuclear significativa o necrosis tumoral, pero con entre 5 y 15 <span class=\"term\" data-term-id=\"1535\">mitosis<\/span> per high power field.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Diagnostico-diferencial-de-leiomiosarcoma\"><\/span>\n<span class=\"term\" data-term-id=\"813\">Differential diagnosis<\/span> leiomyosarcoma<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Other malignant spindle cell tumors to consider include the spindle cell. <span class=\"term\" data-term-id=\"270\">scaly<\/span> cell <span class=\"term\" data-term-id=\"32\">carcinoma<\/span>evil one <span class=\"term\" data-term-id=\"1374\">peripheral<\/span> nerve sheath tumor, spindle cell <span class=\"term\" data-term-id=\"1670\">melanoma<\/span>, angiosarcoma or atypical fibroxanthoma. Immunoperoxidase staining is generally required to differentiate between these lesions.<\/p>\n<\/section>","protected":false},"excerpt":{"rendered":"<p>Leiomiosarcoma es un maligno tumor de m\u00fasculo liso Raramente afecta la piel. Histolog\u00eda de leiomiosarcoma El poder de exploraci\u00f3n de la histolog\u00eda del leiomiosarcoma muestra un mal circunscrito tumor n\u00f3dulo&#8230;<\/p>","protected":false},"author":8,"featured_media":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","format":"standard","meta":{"footnotes":""},"categories":[204],"tags":[205],"class_list":["post-16610","wiki","type-wiki","status-publish","format-standard","category-glosario-definiciones","tag-patologia"],"_links":{"self":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/16610","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki"}],"about":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/types\/wiki"}],"author":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/comments?post=16610"}],"version-history":[{"count":0,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/16610\/revisions"}],"wp:attachment":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/media?parent=16610"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/categories?post=16610"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/tags?post=16610"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}