\nMyxofibrosarcoma is rare Soft fabric<\/span> tumor<\/span>, which usually occurs on the shoulder girdle of the elderly. Is a evil one<\/span> tumor with high risk of local reappearance<\/span>.<\/p>\n<\/span>\nHistology<\/span> myxofibrosarcoma <\/span><\/h3>\nMyxofibrosarcoma presents as a multinodular tumor, with a variable cellular<\/span> spindle cell<\/span> proliferation<\/span> in a myxoid<\/span> background (figures 1, 2). Mobile atypia<\/span> with nuclear<\/span> pleomorphism<\/span> and expanded hyperchromatic<\/span> nuclei<\/span> it is seen at least focally (figure 3). The characteristic feature is the presence of delicate curvilinear vessels (Figures 4,5). <\/p>\n\n\n
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Figure 1<\/p>\n
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Figure 2<\/p>\n
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figure 3<\/p>\n<\/p><\/div>\n<\/section>\n
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The rating falls on a spectrum based on the interpretation of cellularity.<\/p>\n
\n- Low grade: hypocellular without solid<\/span> zones<\/li>\n
- Intermediate grade: myxoid with greater cellularity.<\/li>\n
- High grade: solid tumor with prominent pleomorphism (Figures 6.7) <\/li>\n<\/ul>\n\n
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Figure 4<\/p>\n
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Figure 5<\/p>\n
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Figure 6<\/p>\n<\/p><\/div>\n<\/section>\n
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<\/span>Special stains<\/span><\/h2>\nUsually immunohistochemistry<\/span> It is not useful in myxofibrosarcoma, but is positive for vimentin, and sometimes weakly positive for smooth muscle actin and CD34. <\/p>\n<\/span>Variants of myxofibrosarcoma<\/span><\/h2>\nEpithelioid<\/span>: Cell areas morphologically<\/span> epithelioid behave as high-grade, and are prone to increased local recurrence and risk of metastasis<\/span>. <\/p>\n\n\n
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Figure 7<\/p>\n
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Figure 8<\/p>\n
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Figure 9<\/p>\n<\/p><\/div>\n<\/section>\n
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<\/span>Differential diagnosis<\/span><\/span><\/h2>\nLow-grade fibromyxoid sarcoma<\/span>: Typically paucicellular with alternate fibrous and myxoid areas. Nuclear pleomorphism is mild or absent.<\/p>\nMyxoid liposarcoma: This tumor has lipoblasts and lacks significant pleomorphism. Vacuoles within lipoblasts will be clear, unlike myxofibrosarcoma, where vacuoles typically contain fine myxoid material (pseudolipoblasts) (Figures 8,9). Genetics will show a t (12; 16) or t (12; 22) translocation<\/span>, while MDM2 is frequently negative.<\/p>\nMyxoid dermatofibrosarcoma protuberans: stormy pattern with positive CD34 immunostaining.<\/p>\n
Malignant fibrous histiocytoma: this entity behaves and is probably synonymous with high-grade myxofibrosarcoma.<\/p>\n<\/section>","protected":false},"excerpt":{"rendered":"
El mixofibrosarcoma es poco frecuente Tejido suave tumor, que generalmente se presenta en la cintura escapular de los ancianos. Es un maligno tumor con alto riesgo de local reaparici\u00f3n. Histolog\u00eda…<\/p>","protected":false},"author":8,"featured_media":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","format":"standard","meta":{"footnotes":""},"categories":[204],"tags":[205],"class_list":["post-16711","wiki","type-wiki","status-publish","format-standard","category-glosario-definiciones","tag-patologia"],"_links":{"self":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/16711","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki"}],"about":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/types\/wiki"}],"author":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/comments?post=16711"}],"version-history":[{"count":0,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/16711\/revisions"}],"wp:attachment":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/media?parent=16711"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/categories?post=16711"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/tags?post=16711"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}