{"id":6512,"date":"2020-04-22T01:04:57","date_gmt":"2020-04-22T04:04:57","guid":{"rendered":"https:\/\/doctorhoogstra.com\/es\/urticaria-cronica\/"},"modified":"2020-04-27T17:26:43","modified_gmt":"2020-04-27T20:26:43","slug":"urticaria-cronica","status":"publish","type":"wiki","link":"https:\/\/doctorhoogstra.com\/en\/wiki\/urticaria-cronica\/","title":{"rendered":"Chronic urticaria"},"content":{"rendered":"<p><\/p><div id=\"ez-toc-container\" class=\"ez-toc-v2_0_88 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 eztoc-toggle-hide-by-default' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/urticaria-cronica\/#Que-es-urticaria\" >What is hives?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/urticaria-cronica\/#Que-es-cronico-%C2%BFurticaria\" >What is chronic hives?<\/a><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/urticaria-cronica\/#Urticaria-cronica\" >Chronic urticaria<\/a><\/li><\/ul><\/li><\/ul><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/urticaria-cronica\/#%C2%BFQuien-contrae-urticaria-cronica\" >Who gets chronic hives?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/urticaria-cronica\/#%C2%BFCuales-son-las-caracteristicas-clinicas-de-la-urticaria-cronica\" >What are the clinical characteristics of chronic urticaria?<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/urticaria-cronica\/#Evaluacion-de-la-gravedad-de-la-urticaria\" >Evaluation of the severity of urticaria.<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/urticaria-cronica\/#Sistemico-sintomas-en-la-urticaria-espontanea-cronica\" >Systemic symptoms in chronic spontaneous urticaria<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/urticaria-cronica\/#%C2%BFQue-causa-la-urticaria-cronica\" >What causes chronic hives?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/urticaria-cronica\/#%C2%BFComo-se-diagnostica-la-urticaria-cronica\" >How is chronic hives diagnosed?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/urticaria-cronica\/#%C2%BFCual-es-el-tratamiento-para-la-urticaria-cronica\" >What is the treatment for chronic hives?<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/urticaria-cronica\/#Evitar-los-factores-desencadenantes\" >Avoid triggers<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/urticaria-cronica\/#Tratamiento-de-la-urticaria-refractaria-cronica\" >Treatment of chronic refractory urticaria.<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/urticaria-cronica\/#%C2%BFCual-es-el-pronostico-para-la-urticaria-cronica\" >What is the prognosis for chronic hives?<\/a><\/li><\/ul><\/nav><\/div>\n\n<section class=\"textBlock\">\n<h2><span class=\"ez-toc-section\" id=\"Que-es-urticaria\"><\/span>What is it <span class=\"term\" data-term-id=\"1646\">urticaria<\/span>?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Urticaria is a skin condition characterized by <span class=\"term\" data-term-id=\"1933\">cure<\/span> (urticaria) or <span class=\"term\" data-term-id=\"1645\">angioedema<\/span> (swellings, in 10%) or both (in 40%). There are several types of hives.<\/p>\n<ul>\n<li>The name urticaria is derived from the common European nettle. <em>Urtica dioica<\/em>.<\/li>\n<li>A <span class=\"term\" data-term-id=\"302\">bump<\/span> (or <span class=\"term\" data-term-id=\"1010\">bump<\/span>) is a superficial swelling of pale or skin color, usually surrounded by <span class=\"term\" data-term-id=\"90\">erythema<\/span> (redness) that lasts from a few minutes to 24 hours. Usually itchy, may have a burning sensation.<\/li>\n<li>\n<p>Angioedema is a deeper swelling inside the skin or <span class=\"term\" data-term-id=\"188\">mucous<\/span> membranes and can be skin colored or red. It resolves in 72 hours. Angioedema can cause itching or pain but is often <span class=\"term\" data-term-id=\"731\">asymptomatic<\/span>.<\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"Que-es-cronico-%C2%BFurticaria\"><\/span>What is it <span class=\"term\" data-term-id=\"319\">chronic<\/span> urticaria?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Chronic urticaria is hives in which there is daily or episodic scarring or angioedema that is present for more than six weeks. Chronic urticaria can be spontaneous or <span class=\"term\" data-term-id=\"1647\">inducible<\/span>. Both types can coexist.<\/p>\n<p>Inducible or physical urticaria is classified according to the stimulus that causes healing.<\/p>\n<ul>\n<li>Symptomatic dermographism<\/li>\n<li>Cold urticaria<\/li>\n<li>Cholinergic urticaria<\/li>\n<li>Contact urticaria<\/li>\n<li>Delayed pressure urticaria<\/li>\n<li>Solar urticaria<\/li>\n<li>Heat urticaria<\/li>\n<li>Vibratory urticaria<\/li>\n<li>Aquagenic urticaria<\/li>\n<\/ul>\n<section class=\"textBlock imageLinkBlockTitle\">\n<h5 class=\"colour--primary\"><span class=\"ez-toc-section\" id=\"Urticaria-cronica\"><\/span>Chronic urticaria<span class=\"ez-toc-section-end\"><\/span><\/h5>\n<\/section>\n<section class=\"imageLinkBlock\">\n<div class=\"flex\">\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='urticaria-12__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-2862048-9670883' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/urticaria-12__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-2862048.jpg'>\n<\/div>\n<p class=\"p-small\">Symptomatic dermographism<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='urticaria-13__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-7315422-2822367' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/urticaria-13__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-7315422.jpg'>\n<\/div>\n<p class=\"p-small\">Spontaneous urticaria<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='urticaria-14__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-9195242-6896305' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/urticaria-14__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-9195242.jpg'>\n<\/div>\n<p class=\"p-small\">Spontaneous urticaria<\/p>\n<\/p><\/div>\n<\/section>\n<div class=\"clearfix imageLinkBlock\"><\/div>\n<p>See more hives images.<\/p>\n<div id=\"square-placement-country-holder\" class=\"country-dependent advert\">\n<div class=\"box-placement square-placement\">\n<div class=\"advert__frame\">\n<div id=\"dermnet-dermnet-mobbox\">\n<\/div><\/div><\/div><\/div>\n<h2><span class=\"ez-toc-section\" id=\"%C2%BFQuien-contrae-urticaria-cronica\"><\/span>Who gets chronic hives?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Chronic spontaneous urticaria affects 0.5-2% of the population; in some series, two-thirds are women. Inducible urticaria is more common than chronic spontaneous urticaria. exist <span class=\"term\" data-term-id=\"558\">genetic<\/span> and <span class=\"term\" data-term-id=\"691\">autoimmune<\/span> associations.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%C2%BFCuales-son-las-caracteristicas-clinicas-de-la-urticaria-cronica\"><\/span>What are the clinical characteristics of chronic urticaria?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Hives are characterized by richness.<\/p>\n<ul>\n<li>Scars can affect any site on the body and tend to be widely distributed. <\/li>\n<li>Cracks can be a few millimeters or several centimeters in diameter.<\/li>\n<li>They can be white or red, with or without a red flare.<\/li>\n<li>Each healing may last a few minutes or several hours and may change shape before resolving.<\/li>\n<li>Scars can be round, or form rings, a map-like pattern, or giant patches.<\/li>\n<\/ul>\n<p>Angioedema is more common. <span class=\"term\" data-term-id=\"324\">located<\/span>.<\/p>\n<ul>\n<li>It commonly affects the face (especially presenting as swollen eyelids and lips), hands, feet and genitals.<\/li>\n<li>May involve tongue, uvula, soft palate, and <span class=\"term\" data-term-id=\"864\">larynx<\/span>.<\/li>\n<\/ul>\n<p>In chronic inducible urticaria, scars appear approximately 5 minutes after the stimulus and last a few minutes or up to an hour. Characteristically, the riches are:<\/p>\n<ul>\n<li>\n<span class=\"term\" data-term-id=\"321\">Linear<\/span> in symptomatic dermographism\n<\/li>\n<li>Tiny in cholinergic urticaria\n<\/li>\n<li>Confined to contact areas in contact urticaria\n<\/li>\n<li>\n<span class=\"term\" data-term-id=\"1769\">Diffuse<\/span> in cold hives: if large areas of skin are affected, it can cause fainting (potentially dangerous if swimming in cold water).<\/li>\n<\/ul>\n<p>The scars are more persistent in chronic spontaneous urticaria, but each one has disappeared or changed shape within 24 hours. They can occur at certain times of the day.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Evaluacion-de-la-gravedad-de-la-urticaria\"><\/span>Evaluation of the severity of urticaria.<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Visual <span class=\"term\" data-term-id=\"1502\">analog term<\/span> The scales can be used to record and compare the degree of itch.<\/p>\n<p>Chronic urticaria activity can be assessed using the UAS7 scoring system. Daily healing\/itch scores are added over seven days; The maximum score is 42.<\/p>\n<p>Score 0<\/p>\n<ul>\n<li>There are no healings for 24 hours.<\/li>\n<li>No itching<\/li>\n<\/ul>\n<p>Score 1<\/p>\n<ul>\n<li><20 curas durante 24 horas<\/li>\n<li>mild itching<\/li>\n<\/ul>\n<p>Score 2<\/p>\n<ul>\n<li>20 to 50 cures during 24 hours<\/li>\n<li>moderate itching<\/li>\n<\/ul>\n<p>Score 3<\/p>\n<ul>\n<li>&gt; 50 cures for 24 hours<\/li>\n<li>intense itching<\/li>\n<\/ul>\n<p>The emotional impact of urticaria and its effect on quality of life should also be evaluated. the <span class=\"term\" data-term-id=\"55\">Dermatology<\/span> Quality of life index (<span class=\"term\" data-term-id=\"70\">DLQI<\/span>) and CU-Q<sub>2<\/sub>OL, a chronic urticaria-specific questionnaire, has been validated for chronic urticaria, where sleep disruption is a particular problem.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Sistemico-sintomas-en-la-urticaria-espontanea-cronica\"><\/span>\n<span class=\"term\" data-term-id=\"380\">Systemic<\/span> symptoms in chronic spontaneous urticaria<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Some patients with chronic spontaneous urticaria report several associated systemic symptoms. These include:<\/p>\n<ul>\n<li>Headache and fatigue<\/li>\n<li>Joint pain or inflammation.<\/li>\n<li>Wheezing, redness and palpitations.<\/li>\n<li>Gastrointestinal symptoms. <\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"%C2%BFQue-causa-la-urticaria-cronica\"><\/span>What causes chronic hives?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The scars are due to the release of chemical mediators from the tissue. <span class=\"term\" data-term-id=\"582\">mast cells<\/span> and circulating <span class=\"term\" data-term-id=\"445\">basophils<\/span>. These chemical mediators include <span class=\"term\" data-term-id=\"856\">histamine<\/span>, <span class=\"term\" data-term-id=\"1089\">platelet<\/span>activation factor and <span class=\"term\" data-term-id=\"434\">cytokines<\/span>. Mediators activate the sensory <span class=\"term\" data-term-id=\"952\">nerves<\/span> and cause dilation of <span class=\"term\" data-term-id=\"953\">blood vessels<\/span> and fluid leakage into the surrounding tissues. The release of bradykinin causes angioedema.<\/p>\n<p>Several hypotheses have been proposed to explain urticaria. The immune, arachidonic acid and <span class=\"term\" data-term-id=\"604\">coagulation<\/span> systems are involved and genetic <span class=\"term\" data-term-id=\"871\">mutations<\/span> are under investigation<\/p>\n<p>Chronic spontaneous urticaria is mainly <span class=\"term\" data-term-id=\"862\">idiopathic<\/span> (unknown cause) An autoimmune cause is likely. Approximately half of the patients investigated carry functional IgG <span class=\"term\" data-term-id=\"352\">autoantibodies<\/span> to <span class=\"term\" data-term-id=\"427\">immunoglobulin<\/span> IgE or high affinity <span class=\"term\" data-term-id=\"782\">receiver<\/span> Fc\u03b5RI\u03b1.<\/p>\n<p>Chronic spontaneous urticaria has also been associated with:<\/p>\n<ul>\n<li>Chronic underlying <span class=\"term\" data-term-id=\"145\">infection<\/span>, such as Helicobacter pylori, intestinal parasites<\/li>\n<li>Chronic autoimmune diseases, such as systemic lupus erythematosus, thyroid disease, celiac disease, vitiligo and others.<\/li>\n<li>\n<span class=\"term\" data-term-id=\"976\">Lymphoma<\/span>.<\/li>\n<\/ul>\n<p>Scars in chronic spontaneous urticaria may be aggravated by:<\/p>\n<ul>\n<li>Hot<\/li>\n<li>Viral infection<\/li>\n<li>Tight clothes<\/li>\n<li>\n<p>Pseudoallergy to medications: aspirin, non-steroidal anti-steroids<span class=\"term\" data-term-id=\"490\">inflammatory<\/span> drugs, opiates<\/li>\n<li>Food pseudoallergy: salicylates, azo dyes, food dyes such as tartrazine (102), benzoate preservatives (210-220) and other food additives.<\/li>\n<\/ul>\n<p>Inducible urticaria is a response to a physical stimulus.<\/p>\n<p>Symptomatic dermographism<\/p>\n<ul>\n<li>Stroking or scratching the skin<\/li>\n<li>Tight clothes<\/li>\n<li>Drying towels after a hot shower<\/li>\n<\/ul>\n<p>Cold urticaria<\/p>\n<ul>\n<li>cold air in <span class=\"term\" data-term-id=\"311\">exposed skin<\/span>\n<\/li>\n<li>Cold water<\/li>\n<li>Block of ice<\/li>\n<li><span class=\"term\" data-term-id=\"1145\">Cryotherapy<\/span><\/li>\n<\/ul>\n<p>Cholinergic urticaria<\/p>\n<ul>\n<li>exercise-induced sweat<\/li>\n<li>Sweat induced by emotional discomfort<\/li>\n<li>Hot shower<\/li>\n<\/ul>\n<p>Contact urticaria<\/p>\n<ul>\n<li>Inducing substance absorbed through the skin or <span class=\"term\" data-term-id=\"1485\">mucous membrane<\/span>\n<\/li>\n<li>\n<span class=\"term\" data-term-id=\"409\">Allergens<\/span> (IgE mediated): white flour, cosmetics, textiles, latex, saliva, meat, fish, vegetables<\/li>\n<li>Pseudoallergens or <span class=\"term\" data-term-id=\"1443\">irritants<\/span>: nettle, hairy caterpillar, medicines<\/li>\n<\/ul>\n<p>Delayed pressure urticaria<\/p>\n<ul>\n<li>Pressure on the affected skin several hours before<\/li>\n<li>carry heavy bag<\/li>\n<li>Seat belt pressure.<\/li>\n<li>Standing on a ladder rung<\/li>\n<li>Sitting on a horse<\/li>\n<\/ul>\n<p>Solar urticaria<\/p>\n<ul>\n<li>Sun exposure to non-inhabited body sites<\/li>\n<li>It often does not affect the face, neck, or hands.<\/li>\n<li>May involve long wavelengths <span class=\"term\" data-term-id=\"1910\">UV<\/span> or visible light<\/li>\n<\/ul>\n<p>Heat urticaria<\/p>\n<ul>\n<li>hot water bottle<\/li>\n<li>hot drink<\/li>\n<\/ul>\n<p>Vibratory urticaria<\/p>\n<ul>\n<li>Pneumatic hammer<\/li>\n<\/ul>\n<p>Aquagenic urticaria<\/p>\n<ul>\n<li>hot or cold water<\/li>\n<li>Fresh, salty or chlorinated water<\/li>\n<\/ul>\n<p><span class=\"term\" data-term-id=\"805\">Recurrent<\/span> Angioedema without urticaria may be due to hereditary or acquired <span class=\"term\" data-term-id=\"465\">complement<\/span> C1 esterase deficiency, or long-term use of an anticholinesterase inhibitor drug.<\/p>\n<div id=\"square-placement-country-holder\" class=\"country-dependent advert\">\n<div class=\"box-placement square-placement\">\n<div class=\"advert__frame\">\n<div id=\"dermnet-dermnet-mobbox\">\n<\/div><\/div><\/div><\/div>\n<h2><span class=\"ez-toc-section\" id=\"%C2%BFComo-se-diagnostica-la-urticaria-cronica\"><\/span>How is chronic hives diagnosed?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Chronic urticaria is diagnosed in people with a long history of daily or episodic healing lasting less than 24 hours, with or without angioedema. A family history must be obtained. A complete physical examination should be performed to evaluate the cause. Inducible urticaria is often confirmed by inducing the reaction, such as scratching the skin in dermographism or applying an ice cube in suspected cold urticaria.<\/p>\n<p>There are no routine diagnostic tests in chronic spontaneous urticaria, other than blood count and <span class=\"term\" data-term-id=\"946\">C-reactive protein<\/span> (CBC, <span class=\"term\" data-term-id=\"947\">CRP<\/span>), but investigations may be carried out if an underlying disorder is suspected.<\/p>\n<ul>\n<li>The autologous <span class=\"term\" data-term-id=\"1430\">serum<\/span> Skin testing is sometimes performed in chronic spontaneous urticaria, but its value is uncertain. It is positive if an injection of the patient&#039;s serum under the skin causes red scarring.<\/li>\n<li>Investigations for a systemic condition or <span class=\"term\" data-term-id=\"1251\">autoinflammatory<\/span> disease should be performed in patients with urticaria with <span class=\"term\" data-term-id=\"1176\">fever<\/span>, joint or bone pain, and <span class=\"term\" data-term-id=\"1211\">discomfort<\/span>.<\/li>\n<li>Patients with non-scarring angioedema should be asked if they take ACE inhibitor medications and should have complement C4 testing; C1-INH levels, function and <span class=\"term\" data-term-id=\"426\">antibodies<\/span>; and C1q.<\/li>\n<li>\n<span class=\"term\" data-term-id=\"24\">Biopsy<\/span> Hives can be nonspecific and difficult to interpret. the <span class=\"term\" data-term-id=\"223\">pathology<\/span> shows <span class=\"term\" data-term-id=\"201\">edema<\/span> at <span class=\"term\" data-term-id=\"61\">dermis<\/span> and dilated blood vessels, with a mixed inflammatory variable <span class=\"term\" data-term-id=\"541\">infiltrate<\/span>. Damage to the vessel wall indicates <span class=\"term\" data-term-id=\"293\">urticarial<\/span> <span class=\"term\" data-term-id=\"1091\">vasculitis<\/span>. <\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"%C2%BFCual-es-el-tratamiento-para-la-urticaria-cronica\"><\/span>What is the treatment for chronic hives?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The main treatment for chronic urticaria in adults and children is with a second-generation oral H.<sub>1<\/sub>antihistamine chosen from the list below. If the standard dose (e.g., 10 mg for cetirizine) is not effective, the dose may be increased fourfold (e.g., 40 mg cetirizine daily). There is not thought to be any benefit to adding a second antihistamine.<\/p>\n<ul>\n<li>Cetirizine<\/li>\n<li>Loratadine<\/li>\n<li>Fexofenadine<\/li>\n<li>Desloratadine<\/li>\n<li>Levocetirizine<\/li>\n<li>Rupatadine<\/li>\n<li>Bilastine<\/li>\n<\/ul>\n<p>Terfenadine and astemizole should not be used as they are cardiotoxic in combination with ketoconazole or erythromycin. They are no longer available in New Zealand.<\/p>\n<p>Although systemic treatment is best avoided during pregnancy and breastfeeding, there have been no reports of second-generation antihistamines causing birth defects. If treatment is required, loratadine and cetirizine are currently preferred.<\/p>\n<p>Conventional first-generation antihistamines such as promethazine or chlorpheniramine are no longer recommended for chronic urticaria:<\/p>\n<ul>\n<li>They are of short duration.<\/li>\n<li>They have sedative and anticholinergic side effects.<\/li>\n<li>They damage sleep, learning and performance.<\/li>\n<li>They cause drowsiness in infants if taken by the mother.<\/li>\n<li>They interact with alcohol and other medications.<\/li>\n<li>Lethal overdoses are reported.<\/li>\n<\/ul>\n<h3><span class=\"ez-toc-section\" id=\"Evitar-los-factores-desencadenantes\"><\/span>Avoid triggers<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>In addition to antihistamines, urticaria triggers should be avoided whenever possible. For example:<\/p>\n<ul>\n<li>Treat chronic infections identified as H. pylori.<\/li>\n<li>Avoid aspirin, opiates, and non-steroids. <span class=\"term\" data-term-id=\"1413\">anti-inflammatory<\/span> medications (acetaminophen is generally safe).<\/li>\n<li>Minimize pseudoallergens in the diet for a trial period of at least three weeks.<\/li>\n<li>Avoid known <span class=\"term\" data-term-id=\"1137\">allergies<\/span> that have been confirmed by specific positive IgE \/ skin prick tests if they have clinical relevance for urticaria.<\/li>\n<li>Cool the affected area with a fan, cold flannel, an ice pack, or a soothing moisturizer. <span class=\"term\" data-term-id=\"1120\">lotion<\/span>.<\/li>\n<\/ul>\n<p>Physical triggers of inducible urticaria should be minimized; see examples below. However, symptoms often persist.<\/p>\n<ul>\n<li>Reduce friction in symptomatic dermographism and avoid tight clothing.<\/li>\n<li>Dress carefully in cold or windy conditions and avoid swimming in cold water with cold hives.<\/li>\n<li>Expand the contact area, for example with a heavy bag in delayed pressure urticaria.<\/li>\n<li>Dress and use broad-spectrum sunscreens on solar hives.<\/li>\n<\/ul>\n<p>Some patients with inducible urticaria benefit from daily induction of symptoms to induce tolerance. Phototherapy may be beneficial for symptomatic dermographism.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Tratamiento-de-la-urticaria-refractaria-cronica\"><\/span>Treatment of chronic refractory urticaria.<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Patients with chronic urticaria who have not responded to the maximum dose of second-generation oral antihistamines taken for four weeks should be referred to a <span class=\"term\" data-term-id=\"54\">dermatologist<\/span>, immunologist or doctor <span class=\"term\" data-term-id=\"1136\">allergy<\/span> especialista.<\/p>\n<p>Hay buena evidencia para apoyar el tratamiento con omalizumab o ciclosporina, que tienen una tasa de respuesta del 65% en pacientes resistentes a antihistam\u00ednicos.<\/p>\n<ul>\n<li>\n<p>Omalizumab es un <span class=\"term\" data-term-id=\"466\">monoclonal<\/span> <span class=\"term\" data-term-id=\"425\">antibody<\/span> dirigido contra IgE, con baja <span class=\"term\" data-term-id=\"1160\">toxicity<\/span>. Omalizumab no est\u00e1 financiado por PHARMAC en Nueva Zelanda para la urticaria (2015).<\/li>\n<li>\n<p>La ciclosporina es un inhibidor de la calcineurina, con efectos secundarios potencialmente graves (puede aumentar la presi\u00f3n arterial y reducir <span class=\"term\" data-term-id=\"896\">renal<\/span> funci\u00f3n).<\/li>\n<\/ul>\n<p>Otros tratamientos que a veces se usan fuera de etiqueta en la urticaria cr\u00f3nica incluyen:<\/p>\n<ul>\n<li><span class=\"term\" data-term-id=\"1682\">Leukotrienes<\/span> antagonista, montelukast<\/li>\n<li>Tricyclic antidepressants<\/li>\n<li>Methotrexate<\/li>\n<li>Dapsone<\/li>\n<li>Phototherapy<\/li>\n<li>Agentes alfa anti-TNF, como infliximab, adalimumab\n<\/li>\n<li>\n<p>Intravenous <span class=\"term\" data-term-id=\"428\">immunoglobulins<\/span>.<\/li>\n<\/ul>\n<p>Los corticosteroides sist\u00e9micos a largo plazo generalmente no se recomiendan, ya que a menudo se requieren dosis altas para reducir los s\u00edntomas de la urticaria y tienen efectos adversos inevitables que pueden ser graves. Sin embargo, un estudio publicado en 2018 inform\u00f3 un aclaramiento efectivo y la respuesta duradera de la urticaria espont\u00e1nea cr\u00f3nica a la prednisolona oral.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%C2%BFCual-es-el-pronostico-para-la-urticaria-cronica\"><\/span>What is the prognosis for chronic hives?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Aunque la urticaria cr\u00f3nica desaparece en la mayor\u00eda de los casos, el 15% contin\u00faa teniendo curaci\u00f3n al menos dos veces por semana despu\u00e9s de dos a\u00f1os.<\/p>\n<\/section>","protected":false},"excerpt":{"rendered":"<p>Que es urticaria? La urticaria es una afecci\u00f3n cut\u00e1nea caracterizada por cura (urticaria) o angioedema (hinchazones, en 10%) o ambas (en 40%). Existen varios tipos de urticaria. El nombre de&#8230;<\/p>","protected":false},"author":8,"featured_media":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","format":"standard","meta":{"footnotes":""},"categories":[204],"tags":[],"class_list":["post-6512","wiki","type-wiki","status-publish","format-standard","category-glosario-definiciones"],"_links":{"self":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/6512","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki"}],"about":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/types\/wiki"}],"author":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/comments?post=6512"}],"version-history":[{"count":0,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/6512\/revisions"}],"wp:attachment":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/media?parent=6512"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/categories?post=6512"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/tags?post=6512"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}