\nWhat is Cobb? syndrome<\/span>?<\/span><\/p>\nCobb syndrome is a genetic<\/span> disorder characterized by vascular<\/span> injuries and neurological <\/span>Deficits Also known as spinal arteriovenous metameric syndrome (SAMS) and cutaneous<\/span> meningospinal angiomatosis<\/span>.<\/p>\nAlthough first described by Berenbauch in 1890, the syndrome is most closely associated with Dr. Cobb's description of a clinical case in 1915.<\/p>\n
<\/span>Who gets Cobb syndrome?<\/span><\/h2>\nCobb syndrome is extremely rare.<\/p>\n
\n- There are fewer than 100 cases reported in the literature, although researchers believe the disease may be underreported.<\/li>\n
- Reported cases show that Cobb syndrome is slightly more common in men and Caucasians.<\/li>\n
- The skin symptoms of Cobb syndrome appear at birth, and the neurological symptoms appear by the age of 5 years.<\/li>\n
- Affected children have no family history of Cobb syndrome.<\/li>\n<\/ul>\n
<\/span>What causes Cobb syndrome?<\/span><\/h2>\nThe cause of Cobb syndrome is not completely understood. It is believed that somatic<\/span> mutations<\/span> in the neural crest or mesoderm are responsible for its development quite early in the development of the embryo.<\/p>\n\n
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<\/span>What are the clinical signs of Cobb syndrome?<\/span><\/h2>\nCobb syndrome presents with multiple vascular lesions:<\/p>\n
\n- \nCapillary<\/span> vascular malformations (port wine stains) in a dermatomal<\/span> distribution<\/span> in the trunk<\/li>\n
- Arteriovenous malformations<\/li>\n
- Other vascular injuries, including angioma<\/span>, angiokeratoma<\/span>, angiolipoma<\/span>cavernous hemangioma<\/span>and lymphatic<\/span> malformation<\/span>.<\/li>\n<\/ul>\n
Signs of neurological involvement include:<\/p>\n
\n- Hyperreflexia (hyperactivity of physiological<\/span> reflexes) and sensory and motor defects, including paralysis<\/span>\n<\/li>\n
- \nMorphologic<\/span> (structural) anomalies of the central nervous system.<\/li>\n<\/ul>\n
If neurological symptoms occur, they may occur in intermittent episodes, gradual progression, or with a sudden onset.<\/p>\n
Structural abnormalities of the urinary tract are also reported.<\/p>\n\n<\/span>vascular malformations<\/span><\/h5>\n<\/section>\n\n\n
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Capillary vascular malformation.<\/p>\n
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lymphatic vascular malformation.<\/p>\n
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Angiokeratomas<\/p>\n<\/p><\/div>\n<\/section>\n
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<\/span>What are the complications of Cobb syndrome?<\/span><\/h2>\nPossible complications of Cobb syndrome include:<\/p>\n
\n- Combined kyphosis and scoliosis<\/span>, bone and joint pain due to spinal involvement<\/li>\n
- \nThrombosis<\/span> within arteriovenous malformations<\/li>\n
- \nNecrotic<\/span> myelopathy and Foix-Alajouanine syndrome<\/li>\n
- More rarely, congestive heart failure, and gangrene<\/span>.<\/li>\n<\/ul>\n
<\/span>How is Cobb syndrome diagnosed?<\/span><\/h2>\nCobb syndrome is diagnosed by the presence of multiple cutaneous vascular lesions and neurological defects. Spinal vascular lesions associated with Cobb syndrome can be diagnosed by Magnetic resonance<\/span>, despite Connecticut<\/span> scans, x-ray or angiography<\/span> It can also be used for detection.<\/p>\n\n
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<\/span>How is Cobb syndrome treated?<\/span><\/h2>\nTreatment for Cobb syndrome may include:<\/p>\n
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Endovascular sclerotherapy embolization<\/span> and surgical excision<\/span> of vascular lesions<\/li>\n- oral steroids<\/li>\n
- Physical therapy<\/li>\n
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Compression garments for capillaries, venous<\/span> or lymphatic abnormalities.<\/li>\n<\/ul>\n<\/span>What is the prognosis for Cobb syndrome?<\/span><\/h2>\nThe outlook for children with Cobb syndrome is dependent<\/span> about:<\/p>\n\n- The severity of spinal and neurological involvement.<\/li>\n
- Early detection and intervention to prevent or minimize neurological symptoms.<\/li>\n<\/ul>\n<\/section>","protected":false},"excerpt":{"rendered":"
\u00bfQu\u00e9 es Cobb? s\u00edndrome? El s\u00edndrome de Cobb es un gen\u00e9tico trastorno caracterizado por vascular lesiones y neurol\u00f3gico d\u00e9ficits Tambi\u00e9n se conoce como s\u00edndrome metam\u00e9rico arteriovenoso espinal (SAMS) y cut\u00e1neo…<\/p>","protected":false},"author":8,"featured_media":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","format":"standard","meta":{"footnotes":""},"categories":[204],"tags":[],"class_list":["post-6531","wiki","type-wiki","status-publish","format-standard","category-glosario-definiciones"],"_links":{"self":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/6531","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki"}],"about":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/types\/wiki"}],"author":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/comments?post=6531"}],"version-history":[{"count":0,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/6531\/revisions"}],"wp:attachment":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/media?parent=6531"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/categories?post=6531"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/tags?post=6531"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}