inflammatory<\/span> properties.<\/p>\nIn New Zealand, colchicine is available as 0.5 mg (or 500 microgram) tablets (previously 0.6 mg).<\/p>\n
For its potential toxicity<\/span>, colchicine is used as a second-line agent when safer medications have not been successful.<\/p>\n<\/span>Colchicine for dermatological diseases.<\/span><\/h2>\nColchicine is used for some dermatological diseases. Its effectiveness has only been demonstrated through the treatment of small and mostly uncontrolled study groups.<\/p>\n
\n\n\n| Disease<\/th>\n | Dose<\/th>\n | Effectiveness<\/th>\n<\/tr>\n |
\n| Amyloidosis<\/td>\n | 1-2mg \/ day<\/td>\n | \n\n- Prevent amyloid<\/span> statement<\/span> and slows the progression of the disease<\/li>\n
- It appears to increase life expectancy in patients with primary<\/span> amyloidosis<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
\n| Behcet's disease<\/td>\n | 1-1.5mg \/ day<\/td>\n | \n\n- Response rates of 60-70% have been achieved<\/li>\n
- Orogenital and ocular<\/span> lesions are the most sensitive<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
\n| Psoriasis<\/td>\n | 0.5-3mg \/ day<\/td>\n | \n\n- One of the first skin conditions to be treated with colchicine.<\/li>\n
- Better response in patients with small papules<\/span> and plates<\/span>\n<\/li>\n
- Proven efficacy in treatment generalized<\/span> pustular<\/span> psoriasis, palmoplantar<\/span> pustulosis<\/span>and psoriatic arthritis<\/span>\n<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
\n| Sweet disease<\/td>\n | 0.5-1.5mg \/ day<\/td>\n | \n\n- Improvement in condition after 2-5 days of colchicine 1.5mg daily<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
\n| Recurrent<\/span> aphthous ulcers<\/span><\/td>\n | 1.5-1.8mg \/ day<\/td>\n | \n\n- 0.6mg three times a day has been shown to decrease pain and average ulcer<\/span> tell<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
Other dermatological conditions that can be treated with colchicine include linear<\/span> IgA skin disease<\/span>, acquired epidermolysis bullosa, vasculitis<\/span>, morpho and dermatomyositis.<\/p>\nMore controlled and double-blind<\/span> Studies are needed to demonstrate the usefulness of colchicine in dermatological diseases.<\/p>\n\n \n \n \n<\/div><\/div><\/div><\/div>\n <\/span>\nContraindications<\/span> to colchicine<\/span><\/h2>\nColchicine should not be used in the following circumstances:<\/p>\n \n- Knowledgeable patients hypersensitivity<\/span> (allergy<\/span>) to medicine<\/li>\n
- Patients with severe gastrointestinal, kidney, liver or heart disorders.<\/li>\n
- Patients with blood diseases in which there is a low number of white blood cells or platelets<\/span>\n<\/li>\n
- Patients taking statins (cholesterol<\/span>-low intensity drugs)<\/li>\n
- Pregnant women<\/li>\n<\/ul>\n
<\/span>Precautions when using colchicine<\/span><\/h2>\nColchicine can be fatal in an overdose. Colchicine treatment should be stopped immediately when abdominal pain, diarrhea, nausea or vomiting occurs. These are the first signs of toxicity and usually occur between 0 and 24 hours after taking the drug.<\/p>\n If you are taking other medications, particularly antibiotics and pain relievers, do not take colchicine before checking with your doctor or pharmacist that it is safe to do so.<\/p>\n <\/span>Colchicine Side Effects.<\/span><\/h2>\nThe most common side effects are abdominal pain, diarrhea, nausea, or vomiting, which occur in up to 80% of patients receiving a maximum dose. Gastrointestinal symptoms are worse with higher doses. These symptoms indicate toxicity and the drug should be discontinued.<\/p>\n Toxicity results in:<\/p>\n \n- Bone marrow depression resulting in agranulocytosis (absence of white blood cells) and thrombocytopenia<\/span> (low platelet count)<\/li>\n
- \nPeripheral<\/span> neuritis (nerve inflammation<\/span> affecting hands and feet)<\/li>\n
- \nPurple<\/span> (bleeding into the skin)<\/li>\n
- \nMyopathy<\/span> (weak muscles)<\/li>\n
- waste of hair<\/span>\n<\/li>\n
- Azoospermia (absence of sperm production).<\/li>\n
- Seizures<\/li>\n
- Cardiac arrhythmia<\/span> (palpitations) and low blood pressure<\/li>\n
- Lung, kidney and liver failure<\/li>\n<\/ul>\n
Colchicine, when used in low doses, has a low rate of side effects. The beneficial effects without the side effects are possible by reducing the dose. However, there is no antidote if you take an excessive dose. Seek medical help immediately.<\/p>\n New Zealand approved data sheets are the official source of information for these prescription drugs, including approved uses and risk information. See the New Zealand individual data sheet on the Medsafe website.<\/span><\/em><\/div>\n<\/section>","protected":false},"excerpt":{"rendered":"\u00bfQu\u00e9 es la colchicina? La colchicina es una droga antigua que se hace del azafr\u00e1n de oto\u00f1o, Colchicum oto\u00f1al (una planta venenosa de floraci\u00f3n europea). Se ha utilizado principalmente en…<\/p>","protected":false},"author":8,"featured_media":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","format":"standard","meta":{"footnotes":""},"categories":[204],"tags":[],"class_list":["post-6537","wiki","type-wiki","status-publish","format-standard","category-glosario-definiciones"],"_links":{"self":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/6537","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki"}],"about":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/types\/wiki"}],"author":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/comments?post=6537"}],"version-history":[{"count":0,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/6537\/revisions"}],"wp:attachment":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/media?parent=6537"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/categories?post=6537"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/tags?post=6537"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}} | | | | |