<\/span><\/h2>\nColloid milium<\/span> is a rare condition characterized by a dome shape translucent<\/span> papules<\/span> and dermal<\/span> colloid statement<\/span>. Four variants are recognized: adult, youth<\/span>, pigmented<\/span> and nodular<\/span> colloid milia.<\/p>\n<\/span>\nHistology<\/span> colloid millium<\/span><\/h2>\nIn the papillary dermis<\/span>, homogeneous<\/span> eosinophilic<\/span> masses of a colloid are found (figures 1, 2, 3). The colloid masses are split or cracked<\/span>, and these fissures<\/span> can be lined with fibroblasts<\/span> (figure 4 arrow).<\/p>\nIn adult-type colloidal milia, there is often a grenz zone<\/span> with subepidermal preservation of the papillary dermis<\/span> (figure 5 arrow) and solar elastosis<\/span>. There is a saving of attached<\/span> structures (figure 6).<\/p>\n\n<\/span>Colloidal milio pathology<\/span><\/h5>\n<\/section>\n\n\n
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Figure 1<\/p>\n
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Figure 2<\/p>\n
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figure 3<\/p>\n
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Figure 4<\/p>\n
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Figure 5<\/p>\n
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Figure 6<\/p>\n<\/p><\/div>\n<\/section>\n
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<\/span>Special studies for milium colloid.<\/span><\/h2>\nThe staining is positive for PAS. Congo red and crystal violet can also be positive.<\/p>\n
<\/span>\nDifferential diagnosis<\/span> colloid millium<\/span><\/h2>\nPrimary<\/span> cutaneous<\/span> amyloidosis: Differentiation<\/span> It can be difficult and done only by special stains. Unlike amyloidosis, milium colloid is laminin and type IV negative. collagen<\/span>. Cytokeratin<\/span> is positive in lichen amyloidosis and may be useful in differentiating colloidal milia, which stain negatively; however, nodular amyloid<\/span> and skin involvement systemic<\/span> amyloids are also negative for cytokeratin. Juvenile-type colloidal milia may stain positively for cytokeratin and are considered by some authors to be a variant of lichen amyloidosis. Electron microscopy<\/span> of amyloidosis reveals straight, unbranched filaments, while colloid milia filaments are shorter, branched, and wavy.<\/p>\nErythropoietic protoporphyria: hyaline<\/span> deposits are observed around and within the surface blood vessel<\/span> walls The involvement of the dermoepidermal junction (preserved in colloidal milia) can be seen.<\/p>\nLipoid proteinosis: dermal deposits are accentuated around blood vessels<\/span>. Atrophy<\/span> of eccrine<\/span> Sweat glands and the involvement of pilosebaceous units are additional features. Unlike milium colloid, there is positive staining for laminin, type IV collagen, and cytokeratin.<\/p>\nWoody<\/span> conjunctivitis<\/span>: Juvenile colloidal milia have been reported to be associated with this chronic<\/span> pseudomembranous conjunctivitis. Plasminogen deficiency may be a common causality. Histology of woody conjunctivitis reveals thinned or eroded conjunctiva epithelium<\/span>subepithelial amorphous<\/span> eosinophilic masses and foci of granulation tissue<\/span>.<\/p>\n<\/section>","protected":false},"excerpt":{"rendered":"Introducci\u00f3n Coloide milium es una condici\u00f3n rara caracterizada por una forma de domo transl\u00facido p\u00e1pulas y d\u00e9rmico coloide declaraci\u00f3n. Se reconocen cuatro variantes: adulto, juvenil, pigmentado y nodular milio coloide….<\/p>","protected":false},"author":8,"featured_media":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","format":"standard","meta":{"footnotes":""},"categories":[204],"tags":[205],"class_list":["post-6542","wiki","type-wiki","status-publish","format-standard","category-glosario-definiciones","tag-patologia"],"_links":{"self":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/6542","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki"}],"about":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/types\/wiki"}],"author":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/comments?post=6542"}],"version-history":[{"count":0,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/6542\/revisions"}],"wp:attachment":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/media?parent=6542"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/categories?post=6542"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/tags?post=6542"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}