<\/span><\/h2>\nSkin changes can often be the first sign<\/span> of a deeper problem including internal malignancy. Signs of skin disease can precede, occur, or follow detection of associated diseases. Cancer<\/span>. These skin diseases can be a feature of undiagnosed cancer and may be the indication for a thorough examination in patients. Or in a patient whose cancer is in remission<\/span>, these skin diseases can be the initial sign of cancer recurrence.<\/p>\nSkin markers can be classified into 2 main types:<\/p>\n
\n- Genetically determined syndromes with a cutaneous component (genodermatosis<\/span>) that predispose<\/span> individuals at risk of developing cancer<\/li>\n
- \nParaneoplastic<\/span> syndromes that occur as a result of circulating factors or presumed factors produced by the underlying cancer<\/li>\n<\/ul>\n
<\/span>Genodermatosis<\/span><\/h2>\nSkin diseases that belong to the group of genodermatoses include:<\/p>\n
\n- Birt - Hogg - Dub\u00e9 syndrome<\/span><\/li>\n
- Cowden's disease<\/li>\n
- Gardner syndrome<\/li>\n
- Gorlin syndromebasal<\/span> cell nevus<\/span> syndrome)<\/li>\n
- Multiple endocrine<\/span> neoplasm<\/span> type 2B<\/li>\n
- Neurofibromatosis<\/span><\/li>\n
- Peutz-Jeghers syndrome<\/li>\n
- Torre-Muir syndrome <\/li>\n
- \n
Progeria (premature aging syndromes)<\/li>\n<\/ul>\n
\n
\n
\n
\n<\/div><\/div><\/div><\/div>\n
<\/span>Paraneoplastic syndromes<\/span><\/h2>\nCutaneous paraneoplastic syndromes can be classified according to the type of injury<\/span> they produce.<\/p>\nPapulosquamous<\/span><\/p>\n\n- Acanthosis<\/span> nigricans<\/li>\n
- Acquired ichthyosis<\/span><\/li>\n
- Paraneoplastic acrokeratosis<\/li>\n
- Extramammary Paget's disease<\/li>\n
- Flowery<\/span> cutaneous papillomatosis<\/span> <\/li>\n
- Palmoplantar<\/span> keratoderma<\/span><\/li>\n
- Pityriasis<\/span> roundabout<\/li>\n
- Leser-Trelat sign<\/li>\n
- Callus palms<\/li>\n<\/ul>\n
Erythematous<\/span><\/p>\n\n- Dermatomyositis<\/li>\n
- Erythema<\/span> Gyratum repens<\/li>\n
- Hypertrophic<\/span> osteoarthropathy and digital clubbing<\/li>\n
- Multicentric reticulohistiocytosis<\/li>\n
- Necrolytic migratory erythema<\/li>\n
- Sweet disease<\/li>\n
- Eosinophilic<\/span> skin disease<\/span> of hematological malignancy<\/li>\n<\/ul>\n
Bullous<\/span><\/p>\n\n- Paraneoplastic pemphigus<\/li>\n<\/ul>\n
Diverse<\/p>\n
\n- \nGeneralized<\/span> granuloma<\/span> annular (rarely)<\/li>\n
- Granulomatous<\/span> dermatitis<\/span><\/li>\n
- Carcinoid syndrome<\/li>\n
- Hypertrichosis<\/span> Lanuginosa acquisita<\/li>\n
- Trousseau syndrome<\/li>\n
- \n
Paraneoplastic pruritus<\/span> (cancer itch)<\/li>\n<\/ul>\nIn addition to skin signs and symptoms, paraneoplastic syndromes can affect the endocrine, neuromuscular, musculoskeletal<\/span>cardiovascular hematological<\/span>, gastrointestinal or renal<\/span> function.<\/p>\nParaneoplastic symptoms can be caused by:<\/p>\n
\n- Immune reaction: antibodies<\/span>, T cells<\/span> or cytokines<\/span>\n<\/li>\n
- Hormones or hormonal precursors.<\/li>\n
- Enzymes<\/span><\/li>\n
- Embryonic or fetal proteins<\/li>\n
- Altered metabolic pathways<\/li>\n
- Unknown factors<\/li>\n<\/ul>\n<\/section>","protected":false},"excerpt":{"rendered":"
Qu\u00e9 son cut\u00e1neo marcadores de interno malignidad? Los cambios en la piel a menudo pueden ser los primeros firmar de un problema m\u00e1s profundo que incluye una neoplasia maligna interna….<\/p>","protected":false},"author":8,"featured_media":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","format":"standard","meta":{"footnotes":""},"categories":[204],"tags":[],"class_list":["post-6635","wiki","type-wiki","status-publish","format-standard","category-glosario-definiciones"],"_links":{"self":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/6635","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki"}],"about":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/types\/wiki"}],"author":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/comments?post=6635"}],"version-history":[{"count":0,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/6635\/revisions"}],"wp:attachment":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/media?parent=6635"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/categories?post=6635"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/tags?post=6635"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}