{"id":6639,"date":"2020-04-22T13:39:02","date_gmt":"2020-04-22T16:39:02","guid":{"rendered":"https:\/\/doctorhoogstra.com\/es\/patologia-del-plasmacitoma-cutaneo\/"},"modified":"2020-05-03T18:25:11","modified_gmt":"2020-05-03T21:25:11","slug":"pathology-of-cutaneous-plasmacytoma","status":"publish","type":"wiki","link":"https:\/\/doctorhoogstra.com\/en\/wiki\/patologia-del-plasmacitoma-cutaneo\/","title":{"rendered":"Pathology of cutaneous plasmacytoma."},"content":{"rendered":"<p><\/p><div id=\"ez-toc-container\" class=\"ez-toc-v2_0_88 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 eztoc-toggle-hide-by-default' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/patologia-del-plasmacitoma-cutaneo\/#Introduccion\" >Introduction<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/patologia-del-plasmacitoma-cutaneo\/#Histologia-de-plasmacitoma\" >Plasmacytoma histology<\/a><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/patologia-del-plasmacitoma-cutaneo\/#Patologia-del-plasmacitoma-cutaneo\" >Pathology of cutaneous plasmacytoma.<\/a><\/li><\/ul><\/li><\/ul><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/patologia-del-plasmacitoma-cutaneo\/#Manchas-especiales-en-plasmacitoma\" >Special spots in plasmacytoma<\/a><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/patologia-del-plasmacitoma-cutaneo\/#Tinciones-especiales-de-plasmacitoma\" >Special plasmacytoma stains<\/a><\/li><\/ul><\/li><\/ul><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n\n<section class=\"textBlock\">\n<h2><span class=\"ez-toc-section\" id=\"Introduccion\"><\/span>Introduction<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span class=\"term\" data-term-id=\"47\">Cutaneous<\/span> Plasmacytoma is a rare manifestation (&lt;1%) of multiple myeloma or <span class=\"term\" data-term-id=\"1513\">plasma<\/span> cell <span class=\"term\" data-term-id=\"613\">leukemia<\/span>. Disproportionately affects IgA and IgD <span class=\"term\" data-term-id=\"1824\">proliferations<\/span> and is associated with worsening <span class=\"term\" data-term-id=\"241\">forecast<\/span>.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Histologia-de-plasmacitoma\"><\/span>\n<span class=\"term\" data-term-id=\"128\">Histology<\/span> plasmacytoma<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>There is a dense <span class=\"term\" data-term-id=\"956\">cellular<\/span> <span class=\"term\" data-term-id=\"541\">infiltrate<\/span> (Figure 1) filling the <span class=\"term\" data-term-id=\"24\">biopsy<\/span> sample. This is composed of a monotonic population of plasma cells (Figure 2).<\/p>\n<p>There are histological classification criteria described by Bartl et al in 1987. Cases can also be classified <span class=\"term\" data-term-id=\"1308\">differentiated<\/span> (grade I), moderately differentiated (grade II) or poorly differentiated (grade III) based on plasma cells <span class=\"term\" data-term-id=\"187\">morphology<\/span>.<\/p>\n<section class=\"textBlock imageLinkBlockTitle\">\n<h5 class=\"colour--primary\"><span class=\"ez-toc-section\" id=\"Patologia-del-plasmacitoma-cutaneo\"><\/span>Pathology of cutaneous plasmacytoma.<span class=\"ez-toc-section-end\"><\/span><\/h5>\n<\/section>\n<section class=\"imageLinkBlock\">\n<div class=\"flex\">\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='plasmacytoma-figure1__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisinkildm4xq-5798624-1048941' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/plasmacytoma-figure1__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsInkiLDM4XQ-5798624.jpg'>\n<\/div>\n<p class=\"p-small\">Figure 1<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='plasmacytoma-figure2__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisinkildjd-5781336-4330852' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/plasmacytoma-figure2__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsInkiLDJd-5781336.jpg'>\n<\/div>\n<p class=\"p-small\">Figure 2<\/p>\n<\/p><\/div>\n<\/section>\n<div class=\"clearfix imageLinkBlock\"><\/div>\n<div id=\"square-placement-country-holder\" class=\"country-dependent advert\">\n<div class=\"box-placement square-placement\">\n<div class=\"advert__frame\">\n<div id=\"dermnet-dermnet-mobbox\">\n<\/div><\/div><\/div><\/div>\n<h2><span class=\"ez-toc-section\" id=\"Manchas-especiales-en-plasmacitoma\"><\/span>Special spots in plasmacytoma<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Plasma cells show a <span class=\"term\" data-term-id=\"466\">monoclonal<\/span> profile confirmed by increased kappa or lambda staining in <span class=\"term\" data-term-id=\"1421\">immunohistochemistry<\/span> (figures 3, 4) or <span class=\"term\" data-term-id=\"1237\">FISH<\/span>. Plasma cells are also highlighted by CD138 immunostaining (Figure 5).<\/p>\n<section class=\"textBlock imageLinkBlockTitle\">\n<h5 class=\"colour--primary\"><span class=\"ez-toc-section\" id=\"Tinciones-especiales-de-plasmacitoma\"><\/span>Special plasmacytoma stains<span class=\"ez-toc-section-end\"><\/span><\/h5>\n<\/section>\n<section class=\"imageLinkBlock\">\n<div class=\"flex\">\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='plasmacytoma-figure3__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-6632132-6219086' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/plasmacytoma-figure3__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-6632132.jpg'>\n<\/div>\n<p class=\"p-small\">figure 3<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='plasmacytoma-figure4__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildezxq-5013709-2011455' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/plasmacytoma-figure4__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDEzXQ-5013709.jpg'>\n<\/div>\n<p class=\"p-small\">Figure 4<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='plasmacytoma-figure5__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisinkildewxq-7871398-3166671' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/plasmacytoma-figure5__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsInkiLDEwXQ-7871398.jpg'>\n<\/div>\n<p class=\"p-small\">Figure 5<\/p>\n<\/p><\/div>\n<\/section>\n<div class=\"clearfix imageLinkBlock\"><\/div>\n<\/section>","protected":false},"excerpt":{"rendered":"<p>Introducci\u00f3n Cut\u00e1neo el plasmacitoma es una manifestaci\u00f3n rara (&lt;1%) de mieloma m\u00faltiple o plasma celda leucemia. Afecta desproporcionadamente a IgA e IgD proliferaciones y se asocia con un empeoramiento pron\u00f3stico&#8230;.<\/p>","protected":false},"author":8,"featured_media":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","format":"standard","meta":{"footnotes":""},"categories":[204],"tags":[205],"class_list":["post-6639","wiki","type-wiki","status-publish","format-standard","category-glosario-definiciones","tag-patologia"],"_links":{"self":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/6639","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki"}],"about":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/types\/wiki"}],"author":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/comments?post=6639"}],"version-history":[{"count":0,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/6639\/revisions"}],"wp:attachment":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/media?parent=6639"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/categories?post=6639"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/tags?post=6639"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}