{"id":6645,"date":"2020-04-22T14:11:39","date_gmt":"2020-04-22T17:11:39","guid":{"rendered":"https:\/\/doctorhoogstra.com\/es\/patologia-cutanea-de-linfoma-de-celulas-t-pleomorficas-pequenas-y-medianas\/"},"modified":"2020-05-03T18:25:11","modified_gmt":"2020-05-03T21:25:11","slug":"patologia-cutanea-de-linfoma-de-celulas-t-pleomorficas-pequenas-y-medianas","status":"publish","type":"wiki","link":"https:\/\/doctorhoogstra.com\/en\/wiki\/patologia-cutanea-de-linfoma-de-celulas-t-pleomorficas-pequenas-y-medianas\/","title":{"rendered":"Skin pathology of small and medium pleomorphic T-cell lymphoma"},"content":{"rendered":"<p><\/p><div id=\"ez-toc-container\" class=\"ez-toc-v2_0_88 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 eztoc-toggle-hide-by-default' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/patologia-cutanea-de-linfoma-de-celulas-t-pleomorficas-pequenas-y-medianas\/#Introduccion\" >Introduction<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/patologia-cutanea-de-linfoma-de-celulas-t-pleomorficas-pequenas-y-medianas\/#Histologia-del-linfoma-cutaneo-de-celulas-T-pleomorfas-pequenas-y-medianas\" >Histolog\u00eda del linfoma cut\u00e1neo de c\u00e9lulas T pleomorfas peque\u00f1as y medianas<\/a><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/patologia-cutanea-de-linfoma-de-celulas-t-pleomorficas-pequenas-y-medianas\/#Patologia-cutanea-de-linfoma-de-celulas-T-pleomorficas-pequenas-y-medianas\" >Skin pathology of small and medium pleomorphic T-cell lymphoma<\/a><\/li><\/ul><\/li><\/ul><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/patologia-cutanea-de-linfoma-de-celulas-t-pleomorficas-pequenas-y-medianas\/#Estudios-especiales-de-linfoma-cutaneo-de-celulas-T-pleomorficas-pequenas-y-medianas\" >Estudios especiales de linfoma cut\u00e1neo de c\u00e9lulas T pleom\u00f3rficas peque\u00f1as y medianas<\/a><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/patologia-cutanea-de-linfoma-de-celulas-t-pleomorficas-pequenas-y-medianas\/#Linfoma-cutaneo-de-celulas-T-pleomorficas-pequenas-y-medianas-%E2%80%93-inmunostain-CD4-y-CD8\" >Linfoma cut\u00e1neo de c\u00e9lulas T pleom\u00f3rficas peque\u00f1as y medianas &#8211; inmunostain CD4 y CD8<\/a><\/li><\/ul><\/li><\/ul><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/patologia-cutanea-de-linfoma-de-celulas-t-pleomorficas-pequenas-y-medianas\/#Diagnostico-diferencial-del-linfoma-cutaneo-de-celulas-T-pleomorfas-pequenas-y-medianas\" >Diagn\u00f3stico diferencial del linfoma cut\u00e1neo de c\u00e9lulas T pleomorfas peque\u00f1as y medianas<\/a><\/li><\/ul><\/nav><\/div>\n\n<section class=\"textBlock\">\n<h2><span class=\"ez-toc-section\" id=\"Introduccion\"><\/span>Introduction<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span class=\"term\" data-term-id=\"47\">Cutaneous<\/span> peque\u00f1o mediano <span class=\"term\" data-term-id=\"1540\">pleomorphic<\/span> <span class=\"term\" data-term-id=\"631\">T cell<\/span> <span class=\"term\" data-term-id=\"976\">lymphoma<\/span> es una forma recientemente descrita de linfoma cut\u00e1neo, que generalmente se presenta como un solitario <span class=\"term\" data-term-id=\"289\">tumor<\/span> en la cabeza \/ cuello o tronco en pacientes de edad avanzada. Algunas autoridades consideran esta entidad como una forma de seudolinfoma debido a su <span class=\"term\" data-term-id=\"1532\">indolent<\/span> clinical course.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Histologia-del-linfoma-cutaneo-de-celulas-T-pleomorfas-pequenas-y-medianas\"><\/span>\n<span class=\"term\" data-term-id=\"128\">Histology<\/span> del linfoma cut\u00e1neo de c\u00e9lulas T pleomorfas peque\u00f1as y medianas<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>En el linfoma cut\u00e1neo de c\u00e9lulas T pleomorfas peque\u00f1as y medianas, las secciones muestran un denso <span class=\"term\" data-term-id=\"1266\">lymphoid<\/span> <span class=\"term\" data-term-id=\"541\">infiltrate<\/span> (figura 1), a menudo con <span class=\"term\" data-term-id=\"543\">infiltration<\/span> de los suprayacentes <span class=\"term\" data-term-id=\"85\">epidermis<\/span> (Figura 2). El infiltrado est\u00e1 compuesto por peque\u00f1as y medianas empresas. <span class=\"term\" data-term-id=\"421\">lymphocytes<\/span> que exhiben bastante marcado <span class=\"term\" data-term-id=\"1539\">pleomorphism<\/span>. Hay pocas celdas m\u00e1s grandes mezcladas (figuras 3, 4, 5). En algunos casos puede haber una poblaci\u00f3n reactiva circundante de otros <span class=\"term\" data-term-id=\"490\">inflammatory<\/span> c\u00e9lulas que pueden causar confusi\u00f3n diagn\u00f3stica.<\/p>\n<section class=\"textBlock imageLinkBlockTitle\">\n<h5 class=\"colour--primary\"><span class=\"ez-toc-section\" id=\"Patologia-cutanea-de-linfoma-de-celulas-T-pleomorficas-pequenas-y-medianas\"><\/span>Skin pathology of small and medium pleomorphic T-cell lymphoma<span class=\"ez-toc-section-end\"><\/span><\/h5>\n<\/section>\n<section class=\"imageLinkBlock\">\n<div class=\"flex\">\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='cd4-fig-1__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-5919431-2064066' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/cd4-fig-1__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-5919431.jpg'>\n<\/div>\n<p class=\"p-small\">Figure 1<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='cd4-fig-2__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-4456291-8193608' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/cd4-fig-2__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-4456291.jpg'>\n<\/div>\n<p class=\"p-small\">Figure 2<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='cd4-fig-3__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-8766983-9823400' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/cd4-fig-3__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-8766983.jpg'>\n<\/div>\n<p class=\"p-small\">figure 3<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='cd4-fig-4__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-6933065-9140490' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/cd4-fig-4__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-6933065.jpg'>\n<\/div>\n<p class=\"p-small\">Figure 4<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='cd4-fig-5__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-5398425-9466583' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/cd4-fig-5__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-5398425.jpg'>\n<\/div>\n<p class=\"p-small\">Figure 5<\/p>\n<\/p><\/div>\n<\/section>\n<div class=\"clearfix imageLinkBlock\"><\/div>\n<div id=\"square-placement-country-holder\" class=\"country-dependent advert\">\n<div class=\"box-placement square-placement\">\n<div class=\"advert__frame\">\n<div id=\"dermnet-dermnet-mobbox\">\n<\/div><\/div><\/div><\/div>\n<h2><span class=\"ez-toc-section\" id=\"Estudios-especiales-de-linfoma-cutaneo-de-celulas-T-pleomorficas-pequenas-y-medianas\"><\/span>Estudios especiales de linfoma cut\u00e1neo de c\u00e9lulas T pleom\u00f3rficas peque\u00f1as y medianas<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>El infiltrado est\u00e1 compuesto principalmente de CD4-positivo. <span class=\"term\" data-term-id=\"417\">T cells<\/span> (figura 6). Las c\u00e9lulas T CD8 positivas son muy pocas en n\u00famero (figura 7). A menudo hay p\u00e9rdida de marcadores de c\u00e9lulas T como CD5 y CD7. CD20 destaca menos reactivo <span class=\"term\" data-term-id=\"430\">B cells<\/span>.<\/p>\n<p>T cell <span class=\"term\" data-term-id=\"782\">receiver<\/span> <span class=\"term\" data-term-id=\"774\">gene<\/span> el reordenamiento puede demostrarse con estudios de reordenamiento.<\/p>\n<section class=\"textBlock imageLinkBlockTitle\">\n<h5 class=\"colour--primary\"><span class=\"ez-toc-section\" id=\"Linfoma-cutaneo-de-celulas-T-pleomorficas-pequenas-y-medianas-%E2%80%93-inmunostain-CD4-y-CD8\"><\/span>Linfoma cut\u00e1neo de c\u00e9lulas T pleom\u00f3rficas peque\u00f1as y medianas &#8211; inmunostain CD4 y CD8<span class=\"ez-toc-section-end\"><\/span><\/h5>\n<\/section>\n<section class=\"imageLinkBlock\">\n<div class=\"flex\">\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='cd4-fig-6__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-7907179-5200735' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/cd4-fig-6__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-7907179.jpg'>\n<\/div>\n<p class=\"p-small\">Figure 6<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='cd4-fig-7__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-8954542-7805349' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/cd4-fig-7__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-8954542.jpg'>\n<\/div>\n<p class=\"p-small\">Figure 7<\/p>\n<\/p><\/div>\n<\/section>\n<div class=\"clearfix imageLinkBlock\"><\/div>\n<h2><span class=\"ez-toc-section\" id=\"Diagnostico-diferencial-del-linfoma-cutaneo-de-celulas-T-pleomorfas-pequenas-y-medianas\"><\/span>\n<span class=\"term\" data-term-id=\"813\">Differential diagnosis<\/span> del linfoma cut\u00e1neo de c\u00e9lulas T pleomorfas peque\u00f1as y medianas<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Micosis fungoide: la presentaci\u00f3n cl\u00ednica es clave para distinguir esta entidad de la micosis fungoide en estadio tumoral. Si el paciente tiene antecedentes de micosis fungoide, se debe tener precauci\u00f3n al diagnosticar el linfoma cut\u00e1neo de c\u00e9lulas T pleom\u00f3rficas peque\u00f1as y medianas.<\/p>\n<p>Pseudolinfoma de c\u00e9lulas T: puede ser similar y muchos casos pueden haberse llamado pseudolinfoma en el pasado. Los estudios inmunohistoqu\u00edmicos y los estudios de reordenamiento de genes de c\u00e9lulas T pueden ser \u00fatiles para ilustrar un <span class=\"term\" data-term-id=\"1678\">clone<\/span> poblaci\u00f3n.<\/p>\n<p><span class=\"term\" data-term-id=\"1374\">Peripheral<\/span> Linfoma de c\u00e9lulas T, no especificado de otra manera: este diagn\u00f3stico debe excluirse mediante correlaci\u00f3n cl\u00ednica como <span class=\"term\" data-term-id=\"241\">forecast<\/span> es claramente mucho peor para un linfoma perif\u00e9rico de c\u00e9lulas T.<\/p>\n<p>Linfoma cut\u00e1neo de c\u00e9lulas B: cuando numerosas c\u00e9lulas B reactivas est\u00e1n presentes en el infiltrado, <span class=\"term\" data-term-id=\"164\">injury<\/span> puede imitar un linfoma de c\u00e9lulas B. El reordenamiento gen\u00e9tico y otros estudios inmunohistoqu\u00edmicos generalmente son necesarios.<\/p>\n<\/section>","protected":false},"excerpt":{"rendered":"<p>Introducci\u00f3n Cut\u00e1neo peque\u00f1o mediano pleom\u00f3rfico C\u00e9lula T linfoma es una forma recientemente descrita de linfoma cut\u00e1neo, que generalmente se presenta como un solitario tumor en la cabeza \/ cuello o&#8230;<\/p>","protected":false},"author":8,"featured_media":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","format":"standard","meta":{"footnotes":""},"categories":[204],"tags":[205],"class_list":["post-6645","wiki","type-wiki","status-publish","format-standard","category-glosario-definiciones","tag-patologia"],"_links":{"self":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/6645","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki"}],"about":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/types\/wiki"}],"author":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/comments?post=6645"}],"version-history":[{"count":0,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/6645\/revisions"}],"wp:attachment":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/media?parent=6645"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/categories?post=6645"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/tags?post=6645"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}