<\/span><\/h2>\nAcute generalized exanthematous pustulosis, or AGEP, is rare pustular<\/span> drug eruption<\/span> characterized by superficial pustules<\/span>.<\/p>\nAGEP is generally classified as severe cutaneous<\/span> adverse reaction<\/span> (SCAR) to a prescription drug. It is also called toxic<\/span> pustuloderma<\/p>\n\n<\/span>The first signs of acute generalized exanthematous pustulosis<\/span><\/h5>\n<\/section>\n\n\n
\n
\n<\/div>\n
\n
\n
\n<\/div>\n
\n
\n
\n<\/div>\n
\n<\/p><\/div>\n<\/section>\n
<\/div>\n
<\/span>Who gets acute generalized exanthematous pustulosis?<\/span><\/h2>\nAGEP has an estimate incidence<\/span> 3 to 5 cases per million inhabitants per year. It occurs in men and women, children and adults.<\/p>\n\n
\n
\n
\n<\/div><\/div><\/div><\/div>\n
<\/span>What causes acute generalized exanthematic pustulosis?<\/span><\/h2>\nMore than 90% of AGEP cases are caused by medications, often beta-lactam antibiotics (penicillins, cephalosporins, and quinolones). Other medications that can cause AGEP are reported to include:<\/p>\n
\n- Tetracyclines<\/li>\n
- Sulfonamides<\/li>\n
- \n
Oral antifungals, particularly terbinafine.\n<\/li>\n
- Calcium channel blockers such as diltiazem.<\/li>\n
- Hydroxychloroquine<\/li>\n
- Carbamazepine<\/li>\n
- Paracetamol.<\/li>\n<\/ul>\n
The onset of AGEP generally occurs within 2 days of exposure to the responsible drug.<\/p>\n
Viral infections (Epstein-Barr virus, enterovirus, adenovirus, cytomegalovirus, hepatitis<\/span> B viruses and others) are common triggers of AGEP in children. Spider bites have also been implicated in some cases. There is a suspicion that some herbal remedies may have caused AGEP.<\/p>\nRecent research suggests that AGEP is associated with IL36RN<\/em> gene<\/span> mutations<\/span>. These genetic<\/span> The abnormalities make the patient more susceptible to pustulosis when certain medications are prescribed or when exposed to infection<\/span>. Similar mutations are also found in some patients with other pustular disorders, such as generalized pustular psoriasis. palmoplantar<\/span> Hallopeau's pustulosis and acrodermatitis continuum.<\/p>\n<\/span>What are the clinical features of acute generalized exanthematous pustulosis?<\/span><\/h2>\nAGEP usually starts on the face or armpits and groin and then becomes more extended<\/span>. It is characterized by the rapid appearance of areas of red skin dotted with sterile pustules the size of a pinhead. There is usually more disease in the skin folds. Facial swelling often arises.<\/p>\nOral lesions affect approximately 20% in patients with AGEP.<\/p>\n
AGEP may be associated with a fever<\/span> and discomfort<\/span>, but often the patient is not particularly ill. Multi-organ involvement is rare but can lead to serious illness. <\/p>\nAGEP persists for one to two weeks and then the skin is peeled off with small collarettes of peeling<\/span> How is it solved<\/p>\n\n<\/span>Morphology of acute generalized exanthematic pustulosis<\/span><\/h5>\n<\/section>\n\n\n
\n
\n<\/div>\n
Pinpoint pustules on an erythematous base<\/p>\n
\n
\n<\/div>\n
Superficial pustules<\/p>\n
\n
\n<\/div>\n
Oral lesions in AGEP<\/p>\n<\/p><\/div>\n<\/section>\n
<\/div>\n
<\/span>What are the complications of acute generalized exanthematous pustulosis?<\/span><\/h2>\nAbout 10% of patients with AGEP have a severe organ-associated reaction. dysfunction<\/span> (lungs, blood, kidneys, liver).<\/p>\nAGEP can overlap with drug hypersensitivity<\/span> syndrome<\/span> or Stevens-Johnson syndrome \/ toxic epidermal<\/span> necrolysis, which can be fatal.<\/p>\nSecondary infection is rare.<\/p>\n
\n
\n
\n
\n<\/div><\/div><\/div><\/div>\n
<\/span>How is acute generalized exanthematic pustulosis diagnosed?<\/span><\/h2>\nAGEP is often diagnosed clinically. Supporting investigations may include:<\/p>\n
\n- Blood test: neutrophilia and elevated. inflammatory<\/span> Markers are often found. Eosinophilia<\/span> and renal<\/span> or hepatic<\/span> Abnormalities may be present and should be monitored.<\/li>\n
- \nBiopsy<\/span> of the skin: subcorneal<\/span> pustules filled with neutrophils<\/span><\/span>. See dermatopathology<\/span> of AGEP.<\/li>\n
- \nPatch<\/span> test: sometimes used to confirm allergy<\/span> to an agent causing AGEP.<\/li>\n<\/ul>\n
<\/span>Which is the differential diagnosis<\/span> for acute generalized exanthematous pustulosis?<\/span><\/h2>\nSkin conditions that can sometimes be difficult to distinguish from AGEP include:<\/p>\n
\n- Stevens-Johnson syndrome \/ toxic epidermal necrolysis<\/li>\n
- Drug hypersensitivity syndrome<\/li>\n
- Another drug rashes<\/span><\/li>\n
- Generalized pustular psoriasis.<\/li>\n
- Neutrophils<\/span> skin disease<\/span><\/li>\n
- \n
Acute located<\/span> exanthematous pustulosis.<\/li>\n<\/ul>\n<\/span>How is acute generalized exanthematous pustulosis treated?<\/span><\/h2>\nAGEP patients are often admitted to the hospital for a few days, but patients can be cared for at home if they feel well enough to eat and drink.<\/p>\n
New drugs should be discontinued after the start of AGEP, particularly antibiotics.<\/p>\n
Treatment is based on relieving symptoms with moisturizers, current<\/span> corticosteroids, oral antihistamines, and pain relievers up to eruption<\/span> solve Systemic<\/span> therapy is rarely indicated.<\/p>\n<\/span>What is the outcome for acute generalized exanthematous pustulosis?<\/span><\/h2>\nThe AGEP rash peels off and resolves spontaneously in about 10 days. It usually does not recur unless the same drug that caused the first episode is taken again. A second episode can be more severe. <\/p>\n\n<\/span>Acute generalized exanthematous pustulosis solution<\/span><\/h5>\n<\/section>\n\n\n
\n
\n<\/div>\n
Peeling<\/p>\n
\n
\n<\/div>\n
Scale Collarettes<\/p>\n
\n
\n<\/div>\n
Palmar skin peeling<\/p>\n<\/p><\/div>\n<\/section>\n
<\/div>\n<\/section>","protected":false},"excerpt":{"rendered":"
Que es agudo generalizado exantematoso pustulosis? La pustulosis exantematosa aguda generalizada, o AGEP, es poco com\u00fan pustuloso f\u00e1rmaco erupci\u00f3n caracterizado por superficial p\u00fastulas. AGEP generalmente se clasifica como grave cut\u00e1neo…<\/p>","protected":false},"author":8,"featured_media":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","format":"standard","meta":{"footnotes":""},"categories":[204],"tags":[],"class_list":["post-6675","wiki","type-wiki","status-publish","format-standard","category-glosario-definiciones"],"_links":{"self":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/6675","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki"}],"about":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/types\/wiki"}],"author":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/comments?post=6675"}],"version-history":[{"count":0,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/6675\/revisions"}],"wp:attachment":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/media?parent=6675"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/categories?post=6675"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/tags?post=6675"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}