<\/span><\/h2>\nLocalized acute exanthematous pustulosis (ALEP) is the localized form of acute generalized<\/span> exanthematous pustulosis (AGEP). It can also be called localized pustular<\/span> drug eruption<\/span> or located toxic<\/span> ALEP pustuloderma is a rare form of drug reaction. It can occur a few days after starting a medication and usually resolves within a week after stopping the medication that triggered it.<\/p>\n\n<\/span>Localized acute exanthematous pustulosis<\/span><\/h5>\n<\/section>\n\n\n
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Localized acute exanthematous pustulosis<\/p>\n
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Localized acute exanthematous pustulosis<\/p>\n<\/p><\/div>\n<\/section>\n
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<\/span>Who gets localized acute exanthematous pustulosis?<\/span><\/h2>\nALEP is very rare and has only been reported in a small number of patients. It has been suggested that younger patients may be at increased risk of developing ALEP, but there is currently not enough information available to confirm this.<\/p>\n
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<\/span>What causes localized acute exanthematous pustulosis?<\/span><\/h2>\nALEP can be caused by various medications. Amoxicillin-containing antibiotics appear to be more commonly associated with ALEP. Other antibiotics, anti-steroids have also been reportedinflammatory<\/span> drugs, antifungal agents, calcium antagonists, anti-ulcer drugs and pembrolizumab.<\/p>\n<\/span>What are the clinical features of localized exanthematous pustulosis?<\/span><\/h2>\nALEP has a sudden onset, presenting as localized clustered white or yellow pustules<\/span> on the surface of a patch<\/span> swollen red (edematous<\/span>) skin, usually on the face. The pustules are usually superficial and flaccid<\/span> and they have a similar appearance to a localized area of AGEP.<\/p>\nALEP patients generally describe the eruption<\/span> like feeling tight or uncomfortable, but the rash is not usually particularly itchy. Some ALEP patients report feeling tired or ill; Mild fevers have been reported in a small number of patients.<\/p>\n<\/span>What are the complications of localized acute exanthematous pustulosis?<\/span><\/h2>\nALEP can lead to post-inflammatory<\/span> pigmentation<\/span> in the affected area It is not known if ALEP can lead to serious Adverse reactions<\/span> to drugs.<\/p>\n\n
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<\/span>How is localized acute exanthematous pustulosis diagnosed?<\/span><\/h2>\nA dermatologist<\/span> You can make the diagnosis of ALEP by recognizing the appearance of the rash and the time frame of its development in relation to a medication, such as an antibiotic. Typically, the patient has previously taken the same medication without an adverse response.<\/p>\nResolution of the rash within days of stopping the triggering medication can help confirm the diagnosis.<\/p>\n
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Microbiology culture<\/span> of pus does not normally reveal bacteria<\/span>.<\/li>\n- Surgical skin biopsy<\/span> it can sometimes be used to help confirm the diagnosis, but is not necessarily required.<\/li>\n
- \nHistological<\/span> features are not ALEP specific but include intraepidermal<\/span> and subcorneal<\/span> pustules with dermal<\/span> papillary edema<\/span> which contains a neutrophilic<\/span> and eosinophilic<\/span> infiltrate<\/span>.<\/li>\n
- The results of the triggering medication patch test are positive in approximately half of patients with ALEP.<\/li>\n<\/ul>\n
<\/span>Which is the differential diagnosis<\/span> for localized acute exanthematous pustulosis?<\/span><\/h2>\nPossible differential diagnoses may include:<\/p>\n
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Infections, including impetigo (bacterial<\/span> skin infection<\/span> because Staphylococcus aureus<\/em>) or eczema<\/span> herpeticum (herpes simplex virus)<\/li>\n- Early stages of acute generalized exanthematous pustulosis\n<\/li>\n
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Generalized pustular psoriasis.\n<\/li>\n
- Acne<\/li>\n
- Newspaper<\/span> dermatitis<\/span><\/li>\n
- Rosacea<\/li>\n<\/ul>\n
<\/span>What is the treatment for localized acute exanthematous pustulosis?<\/span><\/h2>\nElimination of the trigger medication usually leads to a rapid improvement in the rash. Moisturizers (emollients<\/span>) can help calm the skin, but no specific treatment is required.<\/p>\nSkin can heal with residue pigment<\/span> changes (post-inflammatory<\/span> hyperpigmentation<\/span> or post-inflammatory hypopigmentation<\/span>) which generally improves after months or years.<\/p>\nOnce the diagnosis of ALEP is confirmed, the patient should be advised to avoid further use of the trigger medication.<\/p>\n<\/section>","protected":false},"excerpt":{"rendered":"
Que es agudo localizado exantematoso pustulosis? La pustulosis exantematosa aguda localizada (ALEP) es la forma localizada de aguda generalizado pustulosis exantematosa (AGEP). Tambi\u00e9n se puede denominar como localizado pustuloso f\u00e1rmaco…<\/p>","protected":false},"author":8,"featured_media":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","format":"standard","meta":{"footnotes":""},"categories":[204],"tags":[],"class_list":["post-6682","wiki","type-wiki","status-publish","format-standard","category-glosario-definiciones"],"_links":{"self":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/6682","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki"}],"about":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/types\/wiki"}],"author":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/comments?post=6682"}],"version-history":[{"count":0,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/6682\/revisions"}],"wp:attachment":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/media?parent=6682"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/categories?post=6682"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/tags?post=6682"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}