<\/span><\/h2>\nGranular cell tumor<\/span> It is also known as Abrikossoff tumor. It is believed to have a neural origin, probably derived from Schwann cells.<\/p>\n<\/span>\nHistology<\/span> granule cell tumor<\/span><\/h2>\nIn granular cell tumor, sections show wide fascicles<\/span> of tumor cells arranged in nests or leaves that infiltrate the dermis<\/span> and dermal<\/span> structures Tumor cells are large in size, with small, uniform, eosinophilic<\/span> granules<\/span> filling the cytoplasm<\/span>and small, round to oval nuclei<\/span> (Figures 1\u20133). Mitosis<\/span> They are rare.<\/p>\nThe 'pustulo-ovoid bodies of Milian' may be present (figure 2, arrow). These are large granules surrounded by a transparent halo.<\/p>\n
Sometimes the overlap epidermis<\/span> may become noticeably hyperplastic and mimic a scaly<\/span> cell carcinoma<\/span>. This is believed to be a reactive phenomenon.<\/p>\nEvil one<\/span> Granule cell tumor forms are extremely rare but are reported. Frank anaplasia, augmented mitotic<\/span> activity and tumor necrosis<\/span> are worrisome features<\/p>\n\n<\/span>Granular cell tumor pathology<\/span><\/h5>\n<\/section>\n\n\n
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Figure 1<\/p>\n
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Figure 2<\/p>\n
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figure 3<\/p>\n<\/p><\/div>\n<\/section>\n
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<\/span>Special studies for granule cell tumor.<\/span><\/h2>\nThe S-100 protein is positive. PAS highlights the granules after digestion with diastase. Other positive stains may include neuron<\/span>-specific enolase, CD68, CKI-C3.<\/p>\n<\/span>\nDifferential diagnosis<\/span> granule cell tumor pathology<\/span>
\n<\/span><\/h2>\nRhabdomyoma: may be similar to granule cell tumor. Rhabdomyomas are positive with desmin and myoglobin.<\/p>\n
Gingival<\/span> granule cell tumor of the newborn: these are morphologically<\/span> similar to granule cell tumor, but arises in a different clinical setting. S100 is negative.<\/p>\nOther granule cell tumors: Granule cell change has been described in many other tumors (including dermatofibroma, fibrous papule<\/span>, AFX and primitive polypoid granule cell tumor). S100 positivity is generally a useful diagnostic aid.<\/p>\n<\/section>","protected":false},"excerpt":{"rendered":"Introducci\u00f3n C\u00e9lula granular tumor Tambi\u00e9n se conoce como tumor de Abrikossoff. Se cree que tiene un origen neural, probablemente derivado de las c\u00e9lulas de Schwann. Histolog\u00eda del tumor de c\u00e9lulas…<\/p>","protected":false},"author":8,"featured_media":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","format":"standard","meta":{"footnotes":""},"categories":[204],"tags":[205],"class_list":["post-6694","wiki","type-wiki","status-publish","format-standard","category-glosario-definiciones","tag-patologia"],"_links":{"self":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/6694","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki"}],"about":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/types\/wiki"}],"author":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/comments?post=6694"}],"version-history":[{"count":0,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/6694\/revisions"}],"wp:attachment":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/media?parent=6694"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/categories?post=6694"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/tags?post=6694"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}