<\/span><\/h2>\nHopf's acrokeratosis verruciformis is a rare genodermatosis classified as a disorder of keratinization<\/span>. It is often considered a variant of Darier disease. It was first identified in 1931 by Dr. Gustav Hopf, a German dermatologist<\/span>.<\/p>\n<\/span>What is the cause of Hopf's acrokeratosis verruciformis?<\/span><\/h2>\nHopf's acrokeratosis verruciformis is due to an abnormality ATP2A2<\/em> gene<\/span>. Has autosomal<\/span> dominant inheritance, meaning that only one copy of the affected gene needs to be inherited to develop the disease. If one parent is affected, the chance of a child developing Hopf's acrokeratosis verruciformis is 1 in 2 (50%).<\/p>\nMutations<\/span> in ATP2A2<\/em> They also cause Darier disease. The gene encodes the calcium sarcoplasmic reticulum ATPase 2 pump, controlling intracellular<\/span> calcium. It is presumed that the impaired operation of this pump alters the capacity of desmosomes<\/span> to link keratinocytes<\/span> together.<\/p>\n\n
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<\/span>What are the clinical characteristics of Hopf's verruciform acrokeratosis?<\/span><\/h2>\nHopf's verruciform acrokeratosis is characterized by multiple, flat-topped, symmetrical<\/span>skin color keratotic<\/span> injuries to the back of the hands and feet. They are usually present from birth or early childhood, but occasionally emerge in adult life. Other features may include:<\/p>\n\n- \ngrouped<\/span> or isolated papules<\/span> on the knees, elbows and forearms<\/li>\n
- Holes in the palms of the hands and soles of the feet.<\/li>\n
- A dystrophy<\/span>: Pearl white nail<\/span>or nails with longitudinal ridges and nicks on the free edge<\/li>\n<\/ul>\n
The skin changes in Hopf's verruciform acrokeratosis are asymptomatic<\/span> and rarely lead to any complications.<\/p>\n\n<\/span>Hopf Verruciform Acrokeratosis<\/span><\/h5>\n<\/section>\n\n\n
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Hopf Verruciform Acrokeratosis<\/p>\n
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Hopf Verruciform Acrokeratosis<\/p>\n
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Hopf Verruciform Acrokeratosis<\/p>\n
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Hopf Verruciform Acrokeratosis<\/p>\n<\/p><\/div>\n<\/section>\n
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<\/span>How is Hopf's acrokeratosis verruciformis diagnosed?<\/span><\/h2>\nHopf's acrokeratosis verruciformis is diagnosed clinically. This is easier if there are family members with similar skin findings. Sometimes a skin biopsy<\/span> It is done to help with diagnosis.<\/p>\nThe key features in histology<\/span> They are hyperkeratosis<\/span>, acanthosis<\/span>, papillomatosis<\/span> and a thickened granular layer<\/span>. Rarely, acantholysis<\/span> is seen. Circumscribed<\/span> epidermal<\/span> elevations, known as 'church spires' are a distinctive find. See Darier disease pathology<\/span>.<\/p>\n<\/span>What is the treatment for Hopf's acrokeratosis verruciformis?<\/span><\/h2>\nSince Hopf's verruciform acrokeratosis is asymptomatic and located<\/span>, no treatment is required. If a patient prefers treatment for aesthetic reasons, destruction of the papules can be performed with cryotherapy<\/span> or a destructive To be<\/span>. Current<\/span> Tretinoin has also been used to reduce the thickness of papules.<\/p>\n<\/section>","protected":false},"excerpt":{"rendered":"\u00bfQu\u00e9 es la acroqueratosis verruciforme de Hopf? La acroqueratosis verruciforme de Hopf es una genodermatosis rara clasificada como un trastorno de queratinizaci\u00f3n. A menudo se considera una variante de la…<\/p>","protected":false},"author":8,"featured_media":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","format":"standard","meta":{"footnotes":""},"categories":[204],"tags":[],"class_list":["post-6762","wiki","type-wiki","status-publish","format-standard","category-glosario-definiciones"],"_links":{"self":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/6762","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki"}],"about":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/types\/wiki"}],"author":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/comments?post=6762"}],"version-history":[{"count":0,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/6762\/revisions"}],"wp:attachment":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/media?parent=6762"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/categories?post=6762"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/tags?post=6762"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}