<\/span><\/h2>\nAlezzandrini syndrome is characterized by depigmentation<\/span>.<\/p>\n\n- \nUnilateral<\/span> degeneration of the pigmented<\/span> retina layer<\/li>\n
- \nIpsilateral<\/span> facial vitiligo\n<\/li>\n
- \nPoliosis<\/span> (loss of color of a patch<\/span> of hair<\/span>)<\/li>\n
- Reduced hearing <\/li>\n<\/ul>\n
Alezzandrini syndrome has been closely associated with Vogt-Koyanagi-Harada syndrome (VKH), as they share similar cutaneous<\/span> and ocular<\/span> signs. Neurological <\/span>typical implication of VKH syndrome (8)th<\/sup> cranial and sterile nerve damage meningitis<\/span>) are not reported in Alezzandrini syndrome. <\/sup>The connection between the syndromes remains unknown.<\/p>\n<\/span>Who gets Alezzandrini syndrome?<\/span><\/h2>\nOnly a few patients with Alezzandrini syndrome, who were men and women between 12 and 30 years of age at presentation, have been described.<\/p>\n
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<\/span>What causes Alezzandrini syndrome?<\/span><\/h2>\nThe cause of Alezzandrini syndrome remains unknown. Viral or autoimmune<\/span> processes leading to melanocyte<\/span> Destruction has been suggested. Melanocytes<\/span> They migrate to the skin, retinas, uvea, cochlea and vestibular labyrinths, so any of these sites can be affected.<\/p>\n<\/span>What are the clinical features of Alezzandrini syndrome?<\/span><\/h2>\nThe initial presentation may be a unilateral gradual loss of vision, followed by facial vitiligo and ipsilateral poliosis several years later. Reduced sensitivity to ipsilateral sound or hearing loss may also develop. Bilateral<\/span> Deafness has been reported in one patient.<\/p>\n\n<\/span>Loss of pigmentation of the skin and hair.<\/span><\/h5>\n<\/section>\n\n\n
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Poliosis<\/p>\n
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Vitiligo<\/p>\n<\/p><\/div>\n<\/section>\n
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<\/span>How is Alezzandrini syndrome diagnosed?<\/span><\/h2>\nAlezzandrini syndrome is diagnosed by recognizing the clinical presentation.<\/p>\n
Ophthalmological<\/span> Investigations to assess complications may include:<\/p>\n\n- \nEye fundus<\/span> exam<\/li>\n
- Visual acuity test<\/li>\n
- Autofluorescence background<\/li>\n
- Optical coherence tomography-spectral domain image <\/li>\n<\/ul>\n
Audiometry is performed to assess hearing loss.<\/p>\n
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<\/span>What is the treatment for Alezzandrini syndrome?<\/span><\/h2>\nThere are no treatments for Alezzandrini syndrome.<\/p>\n
\n- \nCurrent<\/span> Steroids have limited benefit for vitiligo.<\/li>\n
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Sun protection is important to prevent sunburn on the skin affected by vitiligo.<\/li>\n
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Skin Cancer<\/span> The risk must be evaluated.<\/li>\n<\/ul>\n<\/span>What is the result of Alezzandrini syndrome?<\/span><\/h2>\nDue to the small number of reported cases, the forecast<\/span> of patients with this syndrome remains unknown.<\/p>\nPatients experience gradual loss of vision and, in some cases, progressive<\/span> hearing loss. They have an increased risk of retinal detachment.<\/p>\n<\/section>","protected":false},"excerpt":{"rendered":"\u00bfQu\u00e9 es Alezzandrini? s\u00edndrome? El s\u00edndrome de Alezzandrini se caracteriza por despigmentaci\u00f3n. Unilateral degeneraci\u00f3n de la pigmentado capa de la retina Ipsilateral vitiligo facial Poliosis (p\u00e9rdida de color de un…<\/p>","protected":false},"author":8,"featured_media":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","format":"standard","meta":{"footnotes":""},"categories":[204],"tags":[],"class_list":["post-6848","wiki","type-wiki","status-publish","format-standard","category-glosario-definiciones"],"_links":{"self":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/6848","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki"}],"about":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/types\/wiki"}],"author":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/comments?post=6848"}],"version-history":[{"count":0,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/6848\/revisions"}],"wp:attachment":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/media?parent=6848"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/categories?post=6848"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/tags?post=6848"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}