<\/span><\/h2>\nFogo selvagem, also known as endemic<\/span> foliaceous pemphigus, is a autoimmune<\/span> bullous disease It is a variant of the leaf pemphigus with a single epidemiological<\/span> profile.<\/p>\n<\/span>Who receives fogo selvagem?<\/span><\/h2>\nFogo selvagem is the most predominant<\/span> in rural areas of the southern and mid-western states of Brazil, such as Goi\u00e1s, Mato Grosso do Sul, Paran\u00e1, S\u00e3o Paulo and Minas Gerais. Cases have also been reported in Tunisia, Peru, Paraguay, El Salvador and Colombia. It most often affects children and young adults.<\/p>\nFogo selvagem is closely related to poverty and malnutrition and has a higher incidence<\/span> in areas near rivers and streams. Fogo selvagem is associated with the human White blood cell<\/span> antigen<\/span> complex (HLA<\/span>), indicating a genetic<\/span> predisposition<\/span> to the disease<\/p>\n\n
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<\/span>What causes fogo selvagem?<\/span><\/h2>\nFogo selvagem is an autoimmune disease in which an individual's immune system reacts against keratinocytes<\/span> and desmosomes<\/span> that make up the skin<\/p>\nIn reaction to the foge selvagem, the body produces immunoglobulin<\/span> G4 (IgG4) antibodies<\/span> that bind to the desmosomal protein desmoglein<\/span>-1 (Dsg1). This causes superficial keratinocytes of the epidermis<\/span> separate from each other and fill with fluid, causing the characteristic blisters.<\/p>\nThe exact Pathogenesis<\/span> de fogo selvagem is not known, but it is believed that a combination of genetic and environmental factors is involved. HLA-DRB1-0404, 1402 or 1406 expression alleles<\/span> It is found in patients with fogo selvagem, which suggests a genetic susceptibility. It is presumed that a salivary protein of a blood-sucking insect like the black fly (Simulium nigrimanum<\/em>) triggers the autoimmune response as blackfly bites have been found to be more common in fogo selvagem patients.<\/p>\n<\/span>What are the clinical characteristics of fogo selvagem? <\/span><\/h2>\nThe classic lesions of fogo selvagem are superficial blisters or vesicles<\/span> that progress for weeks or months. Its features include:<\/p>\n\n- Blisters and lesions, which break easily when rubbing the skin.<\/li>\n
- Superficial vesicles, which progress for weeks \/ months.<\/li>\n
- \nErosion<\/span> and crust<\/span> in seborrhea areas, including scalp and face, neck and upper trunk<\/li>\n
- Burning sensation on the skin, reflected in the name: fogo selvagem means forest fire in Portuguese.<\/li>\n<\/ul>\n
<\/span>What are the complications of fogo selvagem?<\/span><\/h2>\nIf not treated, complications can include:<\/p>\n