{"id":6952,"date":"2020-04-23T21:21:15","date_gmt":"2020-04-24T00:21:15","guid":{"rendered":"https:\/\/doctorhoogstra.com\/es\/linfoma-extranodal-de-celulas-nk-t-tipo-nasal-patologia\/"},"modified":"2020-05-03T18:25:15","modified_gmt":"2020-05-03T21:25:15","slug":"extranodal-cell-lymphoma-nk-t-type-nasal-pathology","status":"publish","type":"wiki","link":"https:\/\/doctorhoogstra.com\/en\/wiki\/linfoma-extranodal-de-celulas-nk-t-tipo-nasal-patologia\/","title":{"rendered":"Extranodal NK \/ T cell lymphoma, nasal type, pathology"},"content":{"rendered":"<p><\/p><div id=\"ez-toc-container\" class=\"ez-toc-v2_0_88 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 eztoc-toggle-hide-by-default' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/linfoma-extranodal-de-celulas-nk-t-tipo-nasal-patologia\/#Introduccion\" >Introduction<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/linfoma-extranodal-de-celulas-nk-t-tipo-nasal-patologia\/#Histologia-del-linfoma-extraganglionar-de-celulas-NK-T-tipo-nasal\" >Histology of extranodal NK \/ T cell lymphoma, nasal type<\/a><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/linfoma-extranodal-de-celulas-nk-t-tipo-nasal-patologia\/#Linfoma-extranodal-de-celulas-NK-T-patologia-de-tipo-nasal\" >Extranodal NK \/ T cell lymphoma, nasal-like pathology<\/a><\/li><\/ul><\/li><\/ul><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/linfoma-extranodal-de-celulas-nk-t-tipo-nasal-patologia\/#Estudios-especiales-para-el-linfoma-extranodal-de-celulas-NK-T-tipo-nasal\" >Special studies for extranodal NK \/ T cell lymphoma, nasal type<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/linfoma-extranodal-de-celulas-nk-t-tipo-nasal-patologia\/#Diagnostico-diferencial-del-linfoma-extraganglionar-de-celulas-NK-T-tipo-nasal\" >Differential diagnosis of extranodal NK \/ T cell lymphoma, nasal type<\/a><\/li><\/ul><\/nav><\/div>\n\n<section class=\"textBlock\">\n<h2><span class=\"ez-toc-section\" id=\"Introduccion\"><\/span>Introduction<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span class=\"term\" data-term-id=\"1790\">Extranodal<\/span> NK \/<span class=\"term\" data-term-id=\"416\">T cell<\/span> <span class=\"term\" data-term-id=\"976\">lymphoma<\/span>, nasal type, is a disease driven by the Epstein-Barr virus (EBV) that generally affects mainly the upper respiratory tract (see <span>Associated with the Epstein-Barr virus <span class=\"term\" data-term-id=\"1402\">lymphoproliferative<\/span> disorders)<\/span>. The skin is secondarily involved, but a primarily skin-based disease can also occur.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Histologia-del-linfoma-extraganglionar-de-celulas-NK-T-tipo-nasal\"><\/span>\n<span class=\"term\" data-term-id=\"128\">Histology<\/span> extranodal NK \/ T cell lymphoma, nasal type<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>In extranodal NK \/ T cell lymphoma, nasal type, there is a density <span class=\"term\" data-term-id=\"52\">dermal<\/span> <span class=\"term\" data-term-id=\"541\">infiltrate<\/span> (figure 1) which often extends into the <span class=\"term\" data-term-id=\"1282\">subcutis<\/span>. <span class=\"term\" data-term-id=\"96\">Exocytosis<\/span> of <span class=\"term\" data-term-id=\"1395\">atypical<\/span> <span class=\"term\" data-term-id=\"421\">lymphocytes<\/span> at <span class=\"term\" data-term-id=\"85\">epidermis<\/span> can be seen and can look very much like mycosis fungoides (Figure 2). The infiltrator in the <span class=\"term\" data-term-id=\"61\">dermis<\/span> It is usually <span class=\"term\" data-term-id=\"1064\">polymorphous<\/span> and can include numerous <span class=\"term\" data-term-id=\"858\">histiocytes<\/span> and <span class=\"term\" data-term-id=\"448\">eosinophils<\/span>. Atypical cells are small to medium in size with some larger shapes (Figures 3, 4). Commonly, the insider <span class=\"term\" data-term-id=\"542\">infiltrators<\/span> Vessel walls (Figures 3, 4) cause <span class=\"term\" data-term-id=\"753\">vascular<\/span>. <span class=\"term\" data-term-id=\"1612\">Nuclear<\/span> debris (seen focally in figure 4) and <span class=\"term\" data-term-id=\"403\">necrosis<\/span> It is another common finding.<\/p>\n<section class=\"textBlock imageLinkBlockTitle\">\n<h5 class=\"colour--primary\"><span class=\"ez-toc-section\" id=\"Linfoma-extranodal-de-celulas-NK-T-patologia-de-tipo-nasal\"><\/span>Extranodal NK \/ T cell lymphoma, nasal-like pathology<span class=\"ez-toc-section-end\"><\/span><\/h5>\n<\/section>\n<section class=\"imageLinkBlock\">\n<div class=\"flex\">\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='nktcell-fig-1__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-6895891-4574380' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/nktcell-fig-1__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-6895891.jpg'>\n<\/div>\n<p class=\"p-small\">Figure 1<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='nktcell-fig-2__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-6230121-7337598' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/nktcell-fig-2__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-6230121.jpg'>\n<\/div>\n<p class=\"p-small\">Figure 2<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='nktcell-fig-3__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-5759367-4621543' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/nktcell-fig-3__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-5759367.jpg'>\n<\/div>\n<p class=\"p-small\">figure 3<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='nktcell-fig-4__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-7441658-2716878' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/nktcell-fig-4__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-7441658.jpg'>\n<\/div>\n<p class=\"p-small\">Figure 4<\/p>\n<\/p><\/div>\n<\/section>\n<div class=\"clearfix imageLinkBlock\"><\/div>\n<div id=\"square-placement-country-holder\" class=\"country-dependent advert\">\n<div class=\"box-placement square-placement\">\n<div class=\"advert__frame\">\n<div id=\"dermnet-dermnet-mobbox\">\n<\/div><\/div><\/div><\/div>\n<h2><span class=\"ez-toc-section\" id=\"Estudios-especiales-para-el-linfoma-extranodal-de-celulas-NK-T-tipo-nasal\"><\/span>Special studies for extranodal NK \/ T cell lymphoma, nasal type<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The special spots are essential to make the diagnosis. <span class=\"term\" data-term-id=\"1077\">In the place<\/span> Hybridization with EBV shows that the atypical cells are positive. Atypical cells are generally positive with <span class=\"term\" data-term-id=\"1421\">immunohistochemistry<\/span> for CD56 and granzyme or TIA1. Some cases will express the <span class=\"term\" data-term-id=\"631\">T cell<\/span> CD3 marker. T cell <span class=\"term\" data-term-id=\"774\">gene<\/span> Reorganization studies are often negative.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Diagnostico-diferencial-del-linfoma-extraganglionar-de-celulas-NK-T-tipo-nasal\"><\/span>\n<span class=\"term\" data-term-id=\"813\">Differential diagnosis<\/span> extranodal NK \/ T cell lymphoma, nasal type<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Other <span class=\"term\" data-term-id=\"1374\">peripheral<\/span> T-cell lymphomas and <span class=\"term\" data-term-id=\"900\">subcutaneous<\/span> <span class=\"term\" data-term-id=\"213\">panniculitis<\/span>-how T-cell lymphoma can look like this lymphoma. Positive T-cell gene rearrangement studies and positive T-cell immunohistochemical studies would favor T-cell lymphoma. Expression of EBV, CD56, and granzyme are unusual findings in other T-cell lymphomas.<\/p>\n<\/section>","protected":false},"excerpt":{"rendered":"<p>Introducci\u00f3n Extranodal NK \/c\u00e9lula T linfoma, tipo nasal, es una enfermedad impulsada por el virus de Epstein-Barr (VEB) que generalmente afecta principalmente el tracto respiratorio superior (ver Asociado al virus&#8230;<\/p>","protected":false},"author":8,"featured_media":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","format":"standard","meta":{"footnotes":""},"categories":[204],"tags":[205],"class_list":["post-6952","wiki","type-wiki","status-publish","format-standard","category-glosario-definiciones","tag-patologia"],"_links":{"self":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/6952","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki"}],"about":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/types\/wiki"}],"author":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/comments?post=6952"}],"version-history":[{"count":0,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/6952\/revisions"}],"wp:attachment":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/media?parent=6952"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/categories?post=6952"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/tags?post=6952"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}