{"id":6993,"date":"2020-04-24T01:31:02","date_gmt":"2020-04-24T04:31:02","guid":{"rendered":"https:\/\/doctorhoogstra.com\/es\/inhibidores-del-factor-de-necrosis-tumoral\/"},"modified":"2020-04-27T16:34:47","modified_gmt":"2020-04-27T19:34:47","slug":"tumor-necrosis-factor-inhibitors","status":"publish","type":"wiki","link":"https:\/\/doctorhoogstra.com\/en\/wiki\/inhibidores-del-factor-de-necrosis-tumoral\/","title":{"rendered":"Tumor necrosis factor inhibitors"},"content":{"rendered":"<p><\/p><div id=\"ez-toc-container\" class=\"ez-toc-v2_0_89 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 eztoc-toggle-hide-by-default' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/inhibidores-del-factor-de-necrosis-tumoral\/#%C2%BFQue-son-los-antitumor-necrosis-drogas-alfa\" >What are the antitumor necrosis alpha drugs?<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/inhibidores-del-factor-de-necrosis-tumoral\/#Otras-drogas-anti-TNF\" >Other anti-TNF drugs<\/a><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/inhibidores-del-factor-de-necrosis-tumoral\/#Condiciones-de-la-piel-tratadas-con-inhibidores-del-factor-de-necrosis-tumoral\" >Skin conditions treated with tumor necrosis factor inhibitors<\/a><\/li><\/ul><\/li><\/ul><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/inhibidores-del-factor-de-necrosis-tumoral\/#%C2%BFCuales-son-los-riesgos-de-los-medicamentos-anti-TNF\" >What are the risks of anti-TNF medications?<\/a><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/inhibidores-del-factor-de-necrosis-tumoral\/#Efectos-secundarios-dermatologicos-de-los-inhibidores-del-factor-de-necrosis-tumoral\" >Dermatological side effects of tumor necrosis factor inhibitors<\/a><\/li><\/ul><\/li><\/ul><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n\n<section class=\"textBlock\">\n<h2><span class=\"ez-toc-section\" id=\"%C2%BFQue-son-los-antitumor-necrosis-drogas-alfa\"><\/span>What are anti<span class=\"term\" data-term-id=\"289\">tumor<\/span> <span class=\"term\" data-term-id=\"403\">necrosis<\/span> alpha drugs?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Tumor necrosis factor (TNF) is a <span class=\"term\" data-term-id=\"433\">cytokine<\/span> associate with <span class=\"term\" data-term-id=\"490\">inflammatory<\/span> disorders of the skin, joints and gastrointestinal tract. <\/p>\n<p>The most active anti-TNF drugs are <span class=\"term\" data-term-id=\"466\">monoclonal<\/span> <span class=\"term\" data-term-id=\"426\">antibodies<\/span> directed against TNF-alpha (TNF\u03b1). Anti-TNF\u03b1 drugs <span class=\"term\" data-term-id=\"1854\">control<\/span> <span class=\"term\" data-term-id=\"148\">inflammation<\/span> in inflammatory skin diseases, <span class=\"term\" data-term-id=\"1578\">arthritis<\/span>and intestinal disease. They were among the first biological agents on the market.<\/p>\n<p>Anti-TNF\u03b1 monoclonal antibodies include:<\/p>\n<ul>\n<li>Infliximab<\/li>\n<li>Adalimumab<\/li>\n<li>Etanercept<\/li>\n<li>Golimumab<\/li>\n<li>Certolizumab<\/li>\n<\/ul>\n<h3><span class=\"ez-toc-section\" id=\"Otras-drogas-anti-TNF\"><\/span>Other anti-TNF drugs<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Other drugs with activity against TNF include:<\/p>\n<ul>\n<li>Thalidomide<\/li>\n<li>Sulfasalazine<\/li>\n<li>Pentoxifylline<\/li>\n<li>Bupropion <\/li>\n<\/ul>\n<p><span>Natural compounds that act against TNF include:<\/span><\/p>\n<ul>\n<li>Catechins<\/li>\n<li>Curcumin<\/li>\n<li>Cannabis<\/li>\n<li>Echinacea purpurea<\/li>\n<\/ul>\n<p>For what skin conditions are anti-TNFs used?<\/p>\n<p>Anti-TNF monoclonal antibodies are mainly used in the treatment of serious diseases. <span class=\"term\" data-term-id=\"319\">chronic<\/span> <span class=\"term\" data-term-id=\"235\">license plate<\/span> psoriasis. They are also used for other severe inflammatory skin conditions when conventional therapies have failed. Examples include:<\/p>\n<ul>\n<li>Hidradenitis suppurativa<\/li>\n<li>Skin disease associated with Crohn&#039;s disease.<\/li>\n<li>\n<span class=\"term\" data-term-id=\"1626\">Pyoderma<\/span> gangrenous and PAPA <span class=\"term\" data-term-id=\"350\">syndrome<\/span> (without brand)<\/li>\n<\/ul>\n<section class=\"textBlock imageLinkBlockTitle\">\n<h5 class=\"colour--primary\"><span class=\"ez-toc-section\" id=\"Condiciones-de-la-piel-tratadas-con-inhibidores-del-factor-de-necrosis-tumoral\"><\/span>Skin conditions treated with tumor necrosis factor inhibitors<span class=\"ez-toc-section-end\"><\/span><\/h5>\n<\/section>\n<section class=\"imageLinkBlock\">\n<div class=\"flex\">\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='severe-psoriasis__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-8613792-1580661' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/severe-psoriasis__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-8613792.jpg'>\n<\/div>\n<p class=\"p-small\">Severe psoriasis<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='hydradenitis-suppurative__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisinkildg1xq-9530745-4026129' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/hidradenitis-suppurativa__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsInkiLDg1XQ-9530745.jpg'>\n<\/div>\n<p class=\"p-small\">Hidradenitis suppurativa<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='pyoderma-gangrenosum__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildbd-3018887-6385581' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/pyoderma-gangrenosum__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDBd-3018887.jpg'>\n<\/div>\n<p class=\"p-small\">Gangrenous pyoderma<\/p>\n<\/p><\/div>\n<\/section>\n<div class=\"clearfix imageLinkBlock\"><\/div>\n<h2><span class=\"ez-toc-section\" id=\"%C2%BFCuales-son-los-riesgos-de-los-medicamentos-anti-TNF\"><\/span>What are the risks of anti-TNF medications?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Anti-TNF biologics are administered by injection. They can sometimes cause injection site reactions or infusion reactions. They should be avoided in patients with severe heart failure.<\/p>\n<p>The main risk of anti-TNF therapy is reduced immunity to <span class=\"term\" data-term-id=\"937\">bacterial<\/span>, fungal, viral, and parasitic infections, including:<\/p>\n<ul>\n<li>Tuberculosis<\/li>\n<li>Histoplasmosis<\/li>\n<li>Coccidioidomycosis<\/li>\n<li>Blastomycosis<\/li>\n<\/ul>\n<p>They can also increase the risks of skin cancer and <span class=\"term\" data-term-id=\"691\">autoimmune<\/span> diseases, including demyelinating conditions.<\/p>\n<p>Anti-TNF drugs can lose their effect over time, possibly due to the induction of antibodies against them. Paradoxically, anti-TNF can sometimes cause dermatological side effects, such as:<\/p>\n<ul>\n<li><span class=\"term\" data-term-id=\"1475\">Palmoplantar<\/span> <span class=\"term\" data-term-id=\"1130\">pustulosis<\/span><\/li>\n<li>Various forms of psoriasis\n<\/li>\n<li><span class=\"term\" data-term-id=\"491\">Eczema<\/span><\/li>\n<li>Lupus erythematosus<\/li>\n<li>Morph<\/li>\n<li><span class=\"term\" data-term-id=\"824\">Alopecia<\/span> areata<\/li>\n<li>Vitiligo<\/li>\n<li><span class=\"term\" data-term-id=\"113\">Granuloma<\/span> cancel<\/li>\n<li>Sarcoidosis<\/li>\n<li><span class=\"term\" data-term-id=\"90\">Erythema<\/span> multiform<\/li>\n<li><span class=\"term\" data-term-id=\"1091\">Vasculitis<\/span><\/li>\n<li>Stevens-Johnson syndrome - <span class=\"term\" data-term-id=\"1159\">toxic<\/span> <span class=\"term\" data-term-id=\"846\">epidermal<\/span> necrolysis<\/li>\n<li>\n<p>Numular drug-induced <span class=\"term\" data-term-id=\"53\">dermatitis<\/span> <\/li>\n<\/ul>\n<section class=\"textBlock imageLinkBlockTitle\">\n<h5 class=\"colour--primary\"><span class=\"ez-toc-section\" id=\"Efectos-secundarios-dermatologicos-de-los-inhibidores-del-factor-de-necrosis-tumoral\"><\/span>Dermatological side effects of tumor necrosis factor inhibitors<span class=\"ez-toc-section-end\"><\/span><\/h5>\n<\/section>\n<section class=\"imageLinkBlock\">\n<div class=\"flex\">\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='hand-dermatitis-atnf__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-1201172-7000900' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/hand-dermatitis-aTNF__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-1201172.jpg'>\n<\/div>\n<p class=\"p-small\">Dermatitis of the hand<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='nummular-dermatitis-atnf__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-4995964-1799611' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/nummular-dermatitis-aTNF__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-4995964.jpg'>\n<\/div>\n<p class=\"p-small\">Nummular dermatitis<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='alopecia-areata-atnf__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-3212141-1340217' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/alopecia-areata-aTNF__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-3212141.jpg'>\n<\/div>\n<p class=\"p-small\">Alopecia areata<\/p>\n<\/p><\/div>\n<\/section>\n<div class=\"clearfix imageLinkBlock\"><\/div>\n<div class=\"grey-box\"><em><span style=\"font-size: 0.9em;\">New Zealand approved data sheets are the official source of information for these prescription drugs, including approved uses and risk information. See the New Zealand individual data sheet on the Medsafe website.<\/span><\/em><\/div>\n<\/section>","protected":false},"excerpt":{"rendered":"<p>\u00bfQu\u00e9 son los antitumor necrosis drogas alfa? El factor de necrosis tumoral (TNF) es un citocina asociado con inflamatorio trastornos de la piel, articulaciones y tracto gastrointestinal. Los medicamentos anti-TNF&#8230;<\/p>","protected":false},"author":8,"featured_media":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","format":"standard","meta":{"footnotes":""},"categories":[204],"tags":[],"class_list":["post-6993","wiki","type-wiki","status-publish","format-standard","category-glosario-definiciones"],"_links":{"self":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/6993","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki"}],"about":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/types\/wiki"}],"author":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/comments?post=6993"}],"version-history":[{"count":0,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/6993\/revisions"}],"wp:attachment":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/media?parent=6993"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/categories?post=6993"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/tags?post=6993"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}