<\/span><\/h2>\nAutoinflammatory syndromes are defined as conditions caused by an exaggerated response of the innate immune system that results in spontaneous episodes inflammation<\/span> affecting multiple organs. An autoinflammatory syndrome<\/span> can only be diagnosed when there are infectious conditions, malignancy<\/span>, allergic and immunodeficiency conditions have been excluded. Compared to the classic autoimmune<\/span> diseases, autoinflammatory syndromes lack pathogen<\/span> autoantibodies<\/span> and antigen<\/span>-specific T cells<\/span>.<\/p>\n<\/span>Classification of autoinflammatory syndromes.<\/span><\/h2>\nAutoinflammatory syndromes can be inherited through mutations<\/span> to a single gene<\/span> (monogenic<\/span> autoinflammatory syndromes) or, more commonly, are polygenic immune conditions that resemble autoimmune collagen<\/span> disorders The number of conditions included increases as molecular<\/span> and genetic<\/span> Studies reveal the mechanisms of the disease.<\/p>\nA classification system is presented below, with examples of syndromes with dermatological manifestations.<\/p>\n
<\/span>\nHereditary<\/span> fever<\/span> syndromes<\/span><\/h3>\n\n- Family<\/span> Mediterranean fever (FMF)<\/li>\n
- Tumor<\/span> necrosis<\/span> factor receiver<\/span>associated periodic fever syndrome (TRAPS)<\/li>\n
- Hyper-IgD syndrome (HIDS)<\/li>\n<\/ul>\n
<\/span>Other monogenic autoinflammatory syndromes<\/span><\/h3>\n