<\/span><\/h2>\n blue naevi<\/span> They are benign<\/span> lesions that often appear in childhood or adolescence. Blue nevi and dermal<\/span> Melanocytoses are believed to be the result of dermal arrest of precursor cells migrating from the neural crest in a manner similar to congenital<\/span> naevi. GNAQ \/ GNA11 mutations<\/span> They have recently been found in various forms of blue nevi. The causal cells are dendritic. melanocytes<\/span>, which are bipolar or stellate and have long dendritic processes. These cells typically produce abundant melanin<\/span>.<\/p>\n<\/span>Mongolian spots, nevus<\/span> from Ota and nevus from Ito<\/span><\/h2>\nAlso known as dermal melanocytosis, Mongolian spots, nevi of Ota, and nevi of Ito are histopathologically<\/span> similar to blue nevi and are characterized by a sparse population of scattered dendritic melanocytes in the lattice<\/span> dermis<\/span> without stromal alteration (figure 1).<\/p>\n\n<\/span>Mongolian spot pathology<\/span><\/h5>\n<\/section>\n\n\n
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Figure 1<\/p>\n<\/p><\/div>\n<\/section>\n
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<\/span>Common blue nevus<\/span><\/h2>\nHistopathologically, blue nevi have a collection of dendritic melanocytes in the dermis (Figure 2). Pure blue common nevi should not involve epidermis<\/span>. the connective tissue<\/span> around the melanocytes is generally sclerotic<\/span>, sometimes deeply, when described as a scleral blue nevus. Aggregation<\/span> of melanocytes on appendices<\/span> and neurovascular bundles are common. Melanophages<\/span> They are also usually present in large numbers, partially explaining the blue clinical presentation.<\/p>\nUncommon, dendritic melanocytes do not produce melanin (amelanotic<\/span> blue nevus). These cases can cause diagnostic confusion due to their morphological similarity to dermatofibroma or extremely difficult. desmoplastic<\/span> melanoma<\/span> (figure 3). Notably, cutaneous<\/span> metastasis<\/span> of conventional evil one<\/span> melanoma may appear morphologically<\/span> identical to blue nevi.<\/p>\n\n<\/span>Common pathology of blue nevus<\/span><\/h5>\n<\/section>\n\n\n
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Figure 2<\/p>\n
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figure 3<\/p>\n<\/p><\/div>\n<\/section>\n
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<\/span>\nEpithelioid<\/span> blue nevus<\/span><\/h2>\nEpithelioid blue nevus is also called pigmented<\/span> epithelioid melanocytoma. Instead of thin dendritic melanocytes, cells in an epithelioid blue nevus are large, round, and pale in color. cytoplasm<\/span> (Figure 4). the cellular<\/span> morphology<\/span> may be difficult to appreciate without bleaching the section to remove the copious melanin pigment<\/span>. the nuclei<\/span> are generally uniform without mitotic<\/span> exercise. Actually yes mitosis<\/span> are easy to find, the injury<\/span> It is more likely to be an unusual melanoma.<\/p>\nPatients with Carney complex can develop multiple blue epithelioid nevi. Some of these lesions are called animal melanoma, because they resemble the melanoma seen in animals. Figure 5 was, in fact, a gray horse melanoma.<\/p>\n\n<\/span>Epithelioid blue nevus pathology<\/span><\/h5>\n<\/section>\n\n\n
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Figure 4<\/p>\n
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Figure 5<\/p>\n<\/p><\/div>\n<\/section>\n
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<\/span>Cellular blue nevus<\/span><\/h2>\nThe cellular blue nevus is generally much larger than a common blue nevus and generally affects the entire dermis. The superficial subcutis<\/span> It is also often involved. The architecture is a fairly distinctive mass composed of a lobular tongue or tongues in the deep dermis (Figure 6). Cell density is noticeably higher compared to regular blue nevi. Cells can be round, oval, or spindle-shaped. Multinucleate<\/span> giant cells<\/span> they are occasionally seen in cell areas and can be numerous in some cases.<\/p>\nNecrosis<\/span> and \/ or numerous mitoses suggest that the tumor<\/span> it is an unusual melanoma rather than a blue cell nevus.<\/p>\n\n<\/span>Cellular blue nevus pathology<\/span><\/h5>\n<\/section>\n\n\n
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Figure 6<\/p>\n<\/p><\/div>\n<\/section>\n
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<\/span>\nLicense plate<\/span>blue nevus type<\/span><\/h2>\nThese blue nevi are really great common blue nevi. They are sometimes confused clinically with Mongolian spots. They can measure up to 10 cm and are usually congenital.<\/p>\n
Interestingly proliferative<\/span> nodules<\/span> sometimes they occur in plaque-like blue nevi. The nodules resemble epithelioids or, less commonly, cellular blue nevi. The only times we have seen biopsies of plaque-like blue nevus were cases in which these nodules arose and there was clinical concern of evolving melanoma.<\/p>\n<\/span>Combined nevus<\/span><\/h2>\nThe term combined nevus is used to describe two or more distinct nevi cell elements, or neural crest lines differentiation<\/span>, in a single melanocytic<\/span> nevus. For example, some nevi may have components of a dysplastic<\/span> nevus, blue nevus, Spitz nevi and congenital nevi within the same lesion. Combined nevi can be problematic, especially when there is a Spitz component or clone<\/span> epithelioid cells, as they can mimic melanoma that develops in a nevus (Figure 7). They are also clinically problematic, e.g. a small component of blue nevus can easily be mistaken for melanoma that develops into a bland nevus.<\/p>\n\n<\/span>Combined nevus pathology<\/span><\/h5>\n<\/section>\n\n\n
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Figure 7<\/p>\n<\/p><\/div>\n<\/section>\n
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<\/span>\nDifferential diagnosis<\/span> blue nevus<\/span><\/h2>\nBlue nevus pathology<\/span> needs to be differentiated<\/span> since primary<\/span> and metastatic<\/span> melanoma, especially animal melanoma, pigmented Spitz naevus and pigmented spindle cell<\/span> cane.<\/p>\n<\/section>","protected":false},"excerpt":{"rendered":"Introducci\u00f3n Azul naevi son benigno lesiones que a menudo aparecen en la infancia o adolescencia. Nevos azules y d\u00e9rmico Se cree que las melanocitosis son el resultado de la detenci\u00f3n…<\/p>","protected":false},"author":8,"featured_media":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","format":"standard","meta":{"footnotes":""},"categories":[204],"tags":[205],"class_list":["post-7531","wiki","type-wiki","status-publish","format-standard","category-glosario-definiciones","tag-patologia"],"_links":{"self":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/7531","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki"}],"about":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/types\/wiki"}],"author":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/comments?post=7531"}],"version-history":[{"count":0,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/7531\/revisions"}],"wp:attachment":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/media?parent=7531"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/categories?post=7531"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/tags?post=7531"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}