<\/span><\/h2>\nBrunsting-Perry scarring pemphigoid is an autoimmune disorder. This means that an individual's immune system begins to react against his own tissue. In this case, autoantibodies<\/span> react with the components of the basement membrane, particularly the anchorage filament<\/span> laminin component 5, and the hemidesmosome<\/span>-BP180 and BP230 associated proteins. In some patients antibodies<\/span> to collagen<\/span> VII have been described.<\/p>\nIn 20 to 30% of patients with Brunsting-Perry scarring pemphigoid, skin antibodies can be detected in their bloodstream. (indirect positive immunofluorescence<\/span>)<\/p>\n\n
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<\/span>Clinical presentation of Brunsting-Perry cicatricial pemphigoid<\/span><\/h2>\nThe diagnosis of Brunsting-Perry scarring pemphigoid is based on the following characteristics:<\/p>\n
\n- Itch Urticated<\/span> license plate<\/span> located on the head and neck ("urticated" means a bump<\/span>-like a plate similar to urticaria<\/span>\n<\/li>\n
- The plaque enlarges for weeks or months.<\/li>\n
- The blisters arise around the edge of the plate.<\/li>\n
- Occasionally a smaller secondary plate appears.<\/li>\n
- The plaque heals slowly with significant scarring over months or years.<\/li>\n
- Injuries to the scalp are associated with scarring. alopecia<\/span> (hair<\/span> lost)<\/li>\n
- Mucosal membrane lesions can occur months after primary<\/span> injury<\/span>\n<\/li>\n<\/ul>\n
Biopsy<\/span> the characteristics are similar to bullous<\/span> pemphigoid, but without scars.<\/p>\n<\/span>What is the treatment for Brunsting-Perry scarring pemphigoid?<\/span><\/h2>\nThe treatment of Brunsting-Perry scarring pemphigoid is similar to that of classic scarring pemphigoid. The goal of treatment is to promote healing.<\/p>\n
Ultra powerful current<\/span> steroids such as clobetasol propionate may suffice as monotherapy, however many patients require systemic<\/span> Corticosteroids Other immunomodulatory agents used for Brunsting-Perry cicatricial pemphigoid have included:<\/p>\n\n- Methotrexate<\/li>\n
- Dapsone<\/li>\n
- \nExcision<\/span> with a full-thickness skin graft<\/li>\n<\/ul>\n
In general, patients with Brunsting-Perry scarring pemphigoid have better forecast<\/span> than patients with classic scarring pemphigoid or acquired epidermolysis bullosa.<\/p>\n<\/section>","protected":false},"excerpt":{"rendered":"\u00bfQu\u00e9 es Brunsting-Perry? cicatricial penfigoide? Penfigoide cicatricial de Brunsting-Perry (o mucoso penfigoide de membrana) es una variante rara de membrana mucosa penfigoide Es un autoinmune condici\u00f3n ampollosa de la piel…<\/p>","protected":false},"author":8,"featured_media":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","format":"standard","meta":{"footnotes":""},"categories":[204],"tags":[],"class_list":["post-7568","wiki","type-wiki","status-publish","format-standard","category-glosario-definiciones"],"_links":{"self":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/7568","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki"}],"about":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/types\/wiki"}],"author":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/comments?post=7568"}],"version-history":[{"count":0,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/7568\/revisions"}],"wp:attachment":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/media?parent=7568"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/categories?post=7568"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/tags?post=7568"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}