{"id":7604,"date":"2020-04-25T03:58:27","date_gmt":"2020-04-25T06:58:27","guid":{"rendered":"https:\/\/doctorhoogstra.com\/es\/inhibidor-de-la-calcineurina\/"},"modified":"2020-04-27T15:55:54","modified_gmt":"2020-04-27T18:55:54","slug":"inhibidor-de-la-calcineurina","status":"publish","type":"wiki","link":"https:\/\/doctorhoogstra.com\/en\/wiki\/inhibidor-de-la-calcineurina\/","title":{"rendered":"Calcineurin inhibitor"},"content":{"rendered":"<p><\/p><div id=\"ez-toc-container\" class=\"ez-toc-v2_0_88 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 eztoc-toggle-hide-by-default' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/inhibidor-de-la-calcineurina\/#%C2%BFQue-es-la-calcineurina\" >\u00bfQu\u00e9 es la calcineurina?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/inhibidor-de-la-calcineurina\/#%C2%BFQue-es-un-inhibidor-de-la-calcineurina\" >\u00bfQu\u00e9 es un inhibidor de la calcineurina?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/inhibidor-de-la-calcineurina\/#%C2%BFPara-que-se-usan-los-inhibidores-de-la-calcineurina-en-dermatologia\" >\u00bfPara qu\u00e9 se usan los inhibidores de la calcineurina en dermatolog\u00eda?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/inhibidor-de-la-calcineurina\/#Cuales-son-los-actual-inhibidores-de-la-calcineurina\" >Cuales son los actual inhibidores de la calcineurina?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/inhibidor-de-la-calcineurina\/#%C2%BFQue-son-los-inhibidores-orales-de-la-calcineurina\" >\u00bfQu\u00e9 son los inhibidores orales de la calcineurina?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/inhibidor-de-la-calcineurina\/#%C2%BFCuales-son-los-riesgos-de-un-inhibidor-de-la-calcineurina\" >\u00bfCu\u00e1les son los riesgos de un inhibidor de la calcineurina?<\/a><\/li><\/ul><\/nav><\/div>\n\n<section class=\"textBlock\">\n<h2><span class=\"ez-toc-section\" id=\"%C2%BFQue-es-la-calcineurina\"><\/span>\u00bfQu\u00e9 es la calcineurina?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>La calcineurina es un <span class=\"term\" data-term-id=\"956\">cellular<\/span> <span class=\"term\" data-term-id=\"1525\">enzyme<\/span> que cataliza algunos procesos en T- activado<span class=\"term\" data-term-id=\"421\">lymphocytes<\/span>.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%C2%BFQue-es-un-inhibidor-de-la-calcineurina\"><\/span>\u00bfQu\u00e9 es un inhibidor de la calcineurina?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Un inhibidor de la calcineurina detiene el funcionamiento de la calcineurina al unirse a prote\u00ednas en las c\u00e9lulas llamadas inmunofilinas. Los resultados son:<\/p>\n<ul>\n<li>Liberaci\u00f3n reducida de la <span class=\"term\" data-term-id=\"433\">cytokine<\/span> <span class=\"term\" data-term-id=\"915\">interleukin<\/span>-2 de la <span class=\"term\" data-term-id=\"417\">T cells<\/span>\n<\/li>\n<li>Reduced <span class=\"term\" data-term-id=\"631\">T cell<\/span> <span class=\"term\" data-term-id=\"893\">proliferation<\/span>.<\/li>\n<\/ul>\n<div id=\"square-placement-country-holder\" class=\"country-dependent advert\">\n<div class=\"box-placement square-placement\">\n<div class=\"advert__frame\">\n<div id=\"dermnet-dermnet-mobbox\">\n<\/div><\/div><\/div><\/div>\n<h2><span class=\"ez-toc-section\" id=\"%C2%BFPara-que-se-usan-los-inhibidores-de-la-calcineurina-en-dermatologia\"><\/span>\u00bfPara qu\u00e9 se usan los inhibidores de la calcineurina en <span class=\"term\" data-term-id=\"55\">dermatology<\/span>?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Los inhibidores de la calcineurina se usan por v\u00eda t\u00f3pica y sist\u00e9mica para tratar diversos <span class=\"term\" data-term-id=\"490\">inflammatory<\/span> enfermedades de la piel, especialmente:<\/p>\n<ul>\n<li><span class=\"term\" data-term-id=\"922\">Atopic<\/span> <span class=\"term\" data-term-id=\"53\">dermatitis<\/span><\/li>\n<li>Psoriasis<\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"Cuales-son-los-actual-inhibidores-de-la-calcineurina\"><\/span>Which are the <span class=\"term\" data-term-id=\"1330\">current<\/span> inhibidores de la calcineurina?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ul>\n<li>\n<p>Pimecrolimus <span class=\"term\" data-term-id=\"1121\">cream<\/span>\n<\/li>\n<li>\n<p>Tacrolimus <span class=\"term\" data-term-id=\"1122\">ointment<\/span>\n<\/li>\n<\/ul>\n<p>La ciclosporina puede usarse por v\u00eda t\u00f3pica, pero debe estar compuesta <span class=\"term\" data-term-id=\"1157\">extempor\u00e1neamente <\/span>en Nueva Zelanda.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%C2%BFQue-son-los-inhibidores-orales-de-la-calcineurina\"><\/span>\u00bfQu\u00e9 son los inhibidores orales de la calcineurina?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ul>\n<li>Cyclosporine<\/li>\n<li>Tacrolimus<\/li>\n<\/ul>\n<div id=\"square-placement-country-holder\" class=\"country-dependent advert\">\n<div class=\"box-placement square-placement\">\n<div class=\"advert__frame\">\n<div id=\"dermnet-dermnet-mobbox\">\n<\/div><\/div><\/div><\/div>\n<h2><span class=\"ez-toc-section\" id=\"%C2%BFCuales-son-los-riesgos-de-un-inhibidor-de-la-calcineurina\"><\/span>\u00bfCu\u00e1les son los riesgos de un inhibidor de la calcineurina?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Los efectos secundarios y los riesgos del inhibidor de calcineurina espec\u00edfico se describen en los temas individuales.<\/p>\n<p>Como clase de medicamento, la principal preocupaci\u00f3n es el efecto de la calcineurina en la funci\u00f3n renal. Las sospechas de la nefrotoxicidad incluyen:<\/p>\n<ul>\n<li>Aumento de la endotelina-1, un vascoconstrictor<\/li>\n<li>Disminuci\u00f3n del \u00e1cido n\u00edtrico, un vasodilatador.<\/li>\n<li>Mayor transformaci\u00f3n <span class=\"term\" data-term-id=\"523\">growth factor<\/span> beta 1, una causa de <span class=\"term\" data-term-id=\"750\">interstitial<\/span> <span class=\"term\" data-term-id=\"102\">fibrosis<\/span>.<\/li>\n<\/ul>\n<p>El riesgo de nefrotoxicidad se reduce por:<\/p>\n<ul>\n<li>Mantener la dosis de inhibidor de calcineurina lo m\u00e1s baja posible<\/li>\n<li>Agregarlo o reemplazarlo con otro medicamento inmunosupresor con diferentes efectos secundarios y riesgos.<\/li>\n<\/ul>\n<div class=\"grey-box\"><em><span style=\"font-size: 0.9em;\">New Zealand approved data sheets are the official source of information for these prescription drugs, including approved uses and risk information. See the New Zealand individual data sheet on the Medsafe website.<\/span><\/em><\/div>\n<\/section>","protected":false},"excerpt":{"rendered":"<p>\u00bfQu\u00e9 es la calcineurina? La calcineurina es un celular enzima que cataliza algunos procesos en T- activadolinfocitos. \u00bfQu\u00e9 es un inhibidor de la calcineurina? Un inhibidor de la calcineurina detiene&#8230;<\/p>","protected":false},"author":8,"featured_media":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","format":"standard","meta":{"footnotes":""},"categories":[204],"tags":[],"class_list":["post-7604","wiki","type-wiki","status-publish","format-standard","category-glosario-definiciones"],"_links":{"self":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/7604","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki"}],"about":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/types\/wiki"}],"author":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/comments?post=7604"}],"version-history":[{"count":0,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/7604\/revisions"}],"wp:attachment":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/media?parent=7604"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/categories?post=7604"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/tags?post=7604"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}