<\/span><\/h2>\nMucous membrane<\/span> pemphigoid is a autoimmune<\/span> disease characterized by blistering lesions on mucous membranes<\/span>. The areas commonly involved are the oral mucous membrane<\/span> (mouth lining) and conjunctiva<\/span> (mucous membrane that lines the inner surface of the eyelids and the outer surface of the eye). Other areas that may be affected include the nasal passages, esophagus, trachea, and genitals. Sometimes the skin can also be involved where blisters can be found on the face, neck and scalp.<\/p>\nMucous membrane pemphigoid is also called scar<\/span> pemphigoid or oral pemphigoid.<\/p>\nBrunsting Perry cicatricial penmphigoid is a rare variant in which located<\/span> crops of recurrent<\/span> blisters appear inside urticarial<\/span> plates<\/span>, usually on the head and neck. The blisters can burst and cause blood-crusted plaques and scars.<\/p>\n<\/span>Who gets mucous membrane pemphigoid?<\/span><\/h2>\nMucous membrane pemphigoid is predominantly a disease of the elderly with a peak incidence<\/span> around 70 years old. However, childhood cases have been reported. It appears to be twice as common in women as in men.<\/p>\n\n
\n
\n
\n<\/div><\/div><\/div><\/div>\n
<\/span>What are the signs and symptoms of mucous membrane pemphigoid?<\/span><\/h2>\n\n\n\n| Site<\/th>\n | Characteristics<\/th>\n<\/tr>\n |
\n| Eye<\/td>\n | \n\n- Feeling of guts or pain.<\/li>\n
- Conjunctivitis<\/span><\/li>\n
- Lesions form, erode, and heal to go away. scar<\/span> tissue<\/li>\n
- It can lead to vision problems or blindness.<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
\n| Mouth<\/td>\n | \n\n- Blisters first form on the gums near the teeth.<\/li>\n
- The palate, tongue, lips, oral mucosa, floor of the mouth and throat may be affected<\/li>\n
- Painful erosions<\/span> and ulcers<\/span> make it difficult to eat<\/li>\n
- Weight loss and nutritional deficiencies can develop due to hunger.<\/li>\n
- Injuries that occur in the throat (esophagus, trachea and larynx<\/span>) can be deadly<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
\n| Skin<\/td>\n | \n\n- Skin blisters develop in 25-30% patients.<\/li>\n
- Can sting<\/li>\n
- Bleeding may occur if traumatized<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
\n| Nose<\/td>\n | \n\n- Nose bleeds after blowing nose<\/li>\n
- \nCrust<\/span> causing discomfort<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
\n| Genitals<\/td>\n | \n\n- Painful blisters, erosions and swelling of the clitoris, labia and anus in women, and the penis and anus in men.<\/li>\n
- Scarring can lead to severe distortion of the genitals.<\/li>\n
- It may cause difficulty and pain when urinating.<\/li>\n
- Adhesions can lead to narrowing or even closing of the vaginal opening.<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n
<\/span>Mucous membrane pemphigoid<\/span><\/h5>\n<\/section>\n\n\n \n  \n<\/div>\n Cicatricial pemphigoid<\/p>\n \n  \n<\/div>\n Cicatricial pemphigoid<\/p>\n \n  \n<\/div>\n Cicatricial pemphigoid<\/p>\n \n  \n<\/div>\n Cicatricial pemphigoid<\/p>\n \n  \n<\/div>\n Cicatricial pemphigoid<\/p>\n \n  \n<\/div>\n Cicatricial pemphigoid<\/p>\n<\/p><\/div>\n<\/section>\n <\/div>\n <\/span>What causes mucous membrane pemphigoid?<\/span><\/h2>\nMucous membrane pemphigoid is an autoimmune blistering disease, which basically means that an individual's immune system begins to react against its own tissue. In this particular case autoantibodies<\/span> They react with proteins found in mucous membranes and skin tissue, resulting in blistering lesions. The binding site appears to be within the anchoring filaments that help epidermis<\/span> (outer layer of skin) adhere to the dermis<\/span> (inner layer of the skin).<\/p>\n<\/span>How is mucous membrane pemphigoid diagnosed?<\/span><\/h2>\nMucous membrane pemphigoid is suspected by the clinical appearance of blisters and scars. The diagnosis must be confirmed by biopsy<\/span> for histopathological<\/span> examination, and often multiple biopsies<\/span> They are necessary from the edge of the blistered or ulcerated tissue.<\/p>\nAn additional specimen of adjacent<\/span> the tissue can be examined by direct immunofluorescence<\/span> detect immunoglobulins<\/span> along the basement membrane. Blood samples can be tested for skin antibodies<\/span> by indirect immunofluorescence.<\/p>\nPatients with severe illness should undergo a general health and nutrition evaluation, such as ulceration<\/span> of the mouth and esophagus can make feeding difficult.<\/p>\nThe severity of mucous membrane pemphigoid can be assessed using the mucous membrane pemphigoid disease area index (MMPDAI).1<\/sup><\/p>\n\n \n \n \n<\/div><\/div><\/div><\/div>\n <\/span>Treatment of mucous membrane pemphigoid<\/span><\/h2>\nthe primary<\/span> The goal of treatment is to stop blistering, promote healing, and prevent scarring. Mucous membrane pemphigoid is a particularly difficult disease to treat, as it can affect many different parts of the body. A team of medical specialists is usually required for general care. Regular exams are necessary.<\/p>\nLocal medical treatment depends largely on the organs involved.<\/p>\n \n\n\n| Organ<\/th>\n | Specific treatments<\/th>\n<\/tr>\n | \n| Mouth, nose and skin<\/td>\n | \n\n- Regular dental care including dental hygiene measures.<\/li>\n
- \nCurrent<\/span> steroid creams\/ointments\/pastes\/rinse and spit solutions<\/li>\n
- Intralesional steroid injections<\/li>\n
- Cyclosporine Topical Rinse<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
\n| Eye<\/td>\n | \n\n- Corticosteroid eye drops<\/li>\n
- Surgery to release adhesions<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
\n| Esophagus, trachea and larynx<\/td>\n | \n\n- Soft or pureed diet<\/li>\n
- Topical steroids<\/li>\n
- Stenosis dilation<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
\n| \nVulva<\/span>, vagina and anus<\/td>\n | \n\n- Greasy emollient<\/span> like Vaseline applied frequently<\/li>\n
- Local ultrapotent topical corticosteroid (e.g. Clobetasol ointment<\/span>)<\/li>\n
- \nEstrogen<\/span> cream<\/span> intravaginally<\/li>\n
- Use vaginal dilators to prevent adhesions.<\/li>\n
- Surgery to divide adhesions if severe<\/li>\n
- Surgery should be followed by the intense use of corticosteroids and topical dilators to prevent reappearance<\/span> of adhesions<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
Systemic<\/span> Therapy for mild disease may include a tetracycline antibiotic (doxycycline, minocycline, lymecycline) or, less commonly, colchicine, nicotinamide, salazopyrine, sulfapyridine, or sulfamethoxypyridazine.<\/p>\nSystemic therapy for severe disease usually involves a combination of systemic corticosteroids (sometimes in high doses), dapsone, and immunosuppressive agents, particularly:<\/p>\n \n- Cyclophosphamide<\/li>\n
- Azathioprine<\/li>\n
- Mycophenolate<\/li>\n
- Methotrexate<\/li>\n
- Cyclosporine<\/li>\n
- \n
Rituximab<\/li>\n<\/ul>\n Usually a combination of medications is used and the treatment is slowly effective. The ultimate goal is to reduce the dose of systemic steroids while maintaining immunosuppression. Long-term treatment and monitoring are generally required.<\/p>\n Proper wound care is particularly important to promote healing and minimize scarring.<\/p>\n Mucous membrane pemphigoid is a chronic<\/span>, progressive<\/span> disease that responds slowly and often incompletely to treatment. Spontaneous referrals<\/span> They are rare.<\/p>\n<\/section>","protected":false},"excerpt":{"rendered":"Que es mucoso penfigoide de membrana? Membrana mucosa el penfigoide es un autoinmune enfermedad que se caracteriza por lesiones ampollas en membranas mucosas. Las \u00e1reas com\u00fanmente involucradas son la oral…<\/p>","protected":false},"author":8,"featured_media":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","format":"standard","meta":{"footnotes":""},"categories":[204],"tags":[],"class_list":["post-7709","wiki","type-wiki","status-publish","format-standard","category-glosario-definiciones"],"_links":{"self":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/7709","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki"}],"about":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/types\/wiki"}],"author":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/comments?post=7709"}],"version-history":[{"count":0,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/7709\/revisions"}],"wp:attachment":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/media?parent=7709"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/categories?post=7709"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/tags?post=7709"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}} | | | | | | | | |