<\/span><\/h2>\nLymphomas are tumors of the lymph nodes<\/span> and lymphatic<\/span> system.<\/p>\n\n- \nExtranodal<\/span> Lymphomas are tumors that occur in organs or tissues outside the lymphatic system. <\/li>\n
- \nPrimary<\/span> cutaneous lymphomas occur on the skin without evidence of extracutaneous<\/span> disease at diagnosis.<\/li>\n<\/ul>\n
Primary cutaneous lymphoma can be divided into two categories:<\/p>\n
\n- Cutaneous T cell<\/span> lymphoma <\/li>\n
- B cell lymphoma.<\/li>\n<\/ul>\n
Primary cutaneous B-cell lymphomas (PCBL) comprise approximately 20% of cutaneous lymphomas and are described on this page. <\/p>\n
<\/span>What are cutaneous B-cell lymphomas?<\/span><\/h2>\nCutaneous B-cell lymphomas are a evil one<\/span> proliferation<\/span> of lymphocytes<\/span> B cell type. Mutation<\/span> what happens at different points of Cell B<\/span> Development leads to different forms of lymphoma.<\/p>\nIn 2005, the World Health Organization (WHO) and the European Organization for Research and Treatment of Cancer<\/span> The classification (EORTC) reached a consensus classification for cutaneous lymphomas. It was reviewed by the WHO in 2008. The three main types of PCBCL are:<\/p>\n\n- Primary dermal follicle<\/span> central lymphoma (PCFCL)<\/li>\n
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Primary dermal marginal<\/span> zone B- cell lymphoma (PCMZL)<\/li>\n- Primary dermal diffuse<\/span> Large B-cell lymphoma, leg type (PCDLBCL-LT).<\/li>\n<\/ul>\n
Rare cases of PCDLBCL that do not belong to the PCDLBCL-LT or PCFCL groups are classified as PCDLBCL-other. Other entities like anaplastic<\/span> or plasmablastic lymphoma, primary cutaneous T cells Rev.histiocyte<\/span>rich in B-cell lymphomas and primary cutaneous intravascular<\/span> Large B-cell lymphomas are very rare.<\/p>\nDue to differences in treatment and forecast<\/span>, it is important to discern between PCBCL and systemic<\/span> forms of B-cell lymphomas that manifest with secondary skin involvement. <\/p>\n\n<\/span>Cutaneous B-cell lymphoma<\/span><\/h5>\n<\/section>\n\n\n
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Lymphoma FC<\/p>\n
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Cutaneous B-cell lymphoma<\/p>\n
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Cutaneous B-cell lymphoma<\/p>\n<\/p><\/div>\n<\/section>\n
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<\/span>Who gets cutaneous B-cell lymphoma?<\/span><\/h2>\n<\/span>Primary cutaneous lymphoma of the follicular center<\/span><\/h3>\n\n- \nPrimary Lymphoma of the Cutaneous Follicular Center (PCFCL)<\/span> It is the second most common lymphoma in the western world.<\/li>\n
- It is the most common type of PCBCL.<\/li>\n
- It has a 5-year survival of approximately 95%.<\/li>\n
- It affects older patients, median age 60 years.<\/li>\n<\/ul>\n
<\/span>Primary cutaneous B-cell lymphoma of the marginal zone<\/span><\/h3>\nSee B-cell lymphoma of the primary cutaneous marginal zone (PCMZL).<\/p>\n
\n- Men are affected twice as much as women.<\/li>\n
- Some are associated with Borrelia burgdorferi<\/em> infection<\/span> (the cause of Lyme disease) in endemic<\/span> areas of Europe and the United States.<\/li>\n
- It has the best 5-year survival of the 99%.<\/li>\n
- Younger patients are affected, with a median age of 55 years, but it can also be found in children.<\/li>\n<\/ul>\n
<\/span>Diffuse primary cutaneous large B-cell lymphoma, leg type (PCDLBCL-LT)<\/span><\/h3>\n\n- PCDLBCL-LTT is twice as common in women as in men.<\/li>\n
- It has the worst prognosis, with a 5-year survival of 50%.<\/li>\n
- It affects older people with a median age of 76 years.<\/li>\n<\/ul>\n
<\/span>Diffuse primary large B-cell lymphoma, other (PCDLBCL-other)<\/span><\/h3>\n\n- PCDLBCL-other is very rare.<\/li>\n
- It has a variable prognosis.<\/li>\n<\/ul>\n
<\/span>What are the cutaneous signs of cutaneous B-cell lymphoma?<\/span><\/h2>\n<\/span>Primary cutaneous lymphoma of the follicular center<\/span><\/h3>\n\n- \nPCFCL presents with s<\/span>olive tree or grouped<\/span> papules<\/span>, plates<\/span> or nodules<\/span>.<\/li>\n
- These are pink for violaceous<\/span>.<\/li>\n
- They are usually found on the scalp, forehead, or trunk.<\/li>\n
- They are very rarely found on the leg.<\/li>\n<\/ul>\n
Especially when it affects the head or face, PCFCL can simulate rosacea, folliculitis, acne, lupus miliaris (TB), and insect bites. The list of differential diagnoses should also include basal<\/span> cell carcinoma<\/span>, Merkel cell carcinoma, cutaneous lymphoid<\/span> hyperplasia<\/span> and other non-B-cell skin tumors (eg, cutaneous T-cell lymphomas).<\/p>\n<\/span>Primary cutaneous B-cell lymphoma of the marginal zone<\/span><\/h3>\nPCMZL is a low-grade malignant B-cell lymphoma of MALT (mucous membrane<\/span>associated lymphoid tissue). <\/p>\n\n- PCMZL presents with solitary or multiple papules, plaques, or nodules.<\/li>\n
- They are red to purplish in color.<\/li>\n
- They are most often found on the trunk and upper extremities.<\/li>\n<\/ul>\n
Often the lesions appear clinically minor and, in some case reports, can mimic the appearance of basal cell carcinoma. Other differential diagnoses include arthropod<\/span> bites urticaria<\/span>, leukemia<\/span> skin<\/span> and drug-induced pseudolymphoma.<\/p>\n<\/span>Diffuse primary cutaneous large B-cell lymphoma, leg type<\/span><\/h3>\n\n- \nPCDLBCL-LTT presents with s<\/span>multiple or olitary nodules, infiltrated plaques and tumors.<\/li>\n
- Rarely, it occurs as warty<\/span> plates o extended<\/span> garland-like lesions.<\/li>\n
- They are typically red to bluish in color.<\/li>\n
- They are found mainly on one or both legs, but affects other sites at 10-15%.<\/li>\n
- Represents an aggressive subtype of PCBCL.<\/li>\n
- Multiple skin lesions on the leg have a poor prognosis.<\/li>\n<\/ul>\n
<\/span>Diffuse primary cutaneous lymphoma of large B cells, other<\/span><\/h3>\n\n- \nPCDLBCL-other <\/span>includes large B-cell lymphoma, which presents with skin lesions on the head, trunk, or extremities.<\/li>\n
- Blastic plasmacytoid dendritic cell neoplasm<\/span> it presents with plaques similar to hematomas, nodules and tumors. Later it progresses to involve the central nervous system. It represents a type of leukemia cutis.<\/li>\n
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Intravascular large B-cell lymphoma proliferates within the lumen<\/span> when I was little blood vessels<\/span>, mainly in the skin and the central nervous system and later in other organs. Lesions appear as erythematous<\/span>, sensitive nodules, tumors and telangiectasias<\/span> mainly on the trunk and lower legs. Skin lesions can be confused with mycosis fungoides, sarcoidosis, blood vessel<\/span> tumors or leukemia skin.<\/li>\n<\/ul>\n\n<\/span>Intravascular large B-cell lymphoma<\/span><\/h5>\n<\/section>\n\n\n
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Intravascular B-cell lymphoma<\/p>\n
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Intravascular B-cell lymphoma<\/p>\n
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Intravascular B-cell lymphoma<\/p>\n<\/p><\/div>\n<\/section>\n
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<\/span>How is cutaneous B-cell lymphoma diagnosed? <\/span><\/h2>\nThe evaluation of PCBCLs should include a complete history, a physical exam, and a skin exam. Initial blood tests should include:<\/p>\n
\n- Complete and differential blood count<\/li>\n
- Metabolic profile and lactate dehydrogenase.<\/li>\n<\/ul>\n
If the complete blood count shows lymphocytosis, peripheral<\/span> Blood flow cytometry may be needed.<\/p>\nAdequate skin biopsy<\/span> It is also important for evaluation and staging. 4\u20136 mm punch, incisional or excisional biopsies<\/span><\/span> must be obtained and must include the lattice<\/span> dermis<\/span> and subcutaneous<\/span> grease. Surface biopsy samples may not differentiate PCBCLs from reagents or inflammatory<\/span> processes.<\/p>\nExtracutaneous involvement should be evaluated, especially in patients with palpable<\/span>