{"id":7890,"date":"2020-04-26T07:11:11","date_gmt":"2020-04-26T10:11:11","guid":{"rendered":"https:\/\/doctorhoogstra.com\/es\/terapia-de-despigmentacion-para-el-vitiligo\/"},"modified":"2020-07-22T03:06:07","modified_gmt":"2020-07-22T06:06:07","slug":"depigmentation-therapy-for-vitiligo","status":"publish","type":"wiki","link":"https:\/\/doctorhoogstra.com\/en\/wiki\/terapia-de-despigmentacion-para-el-vitiligo\/","title":{"rendered":"Depigmentation therapy for vitiligo"},"content":{"rendered":"<h2><span class=\"ez-toc-section\" id=\"%C2%BFQue-es-el-vitiligo\"><\/span>What is vitiligo?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<section class=\"textBlock\">Vitiligo is a common skin disorder that results in partial loss of <span class=\"term\" data-term-id=\"1521\">pigmentation<\/span>, that is, white patches of skin.<\/p><div id=\"ez-toc-container\" class=\"ez-toc-v2_0_88 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 eztoc-toggle-hide-by-default' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/terapia-de-despigmentacion-para-el-vitiligo\/#%C2%BFQue-es-el-vitiligo\" >What is vitiligo?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/terapia-de-despigmentacion-para-el-vitiligo\/#%C2%BFQuien-es-adecuado-para-la-terapia-de-despigmentacion\" >Who is suitable for depigmentation therapy?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/terapia-de-despigmentacion-para-el-vitiligo\/#Consentimiento-informado-para-el-tratamiento-con-agentes-despigmentantes\" >Informed consent for treatment with depigmenting agents.<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/terapia-de-despigmentacion-para-el-vitiligo\/#Monobencil-eter-de-hidroquinona\" >Hydroquinone monobenzyl ether<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/terapia-de-despigmentacion-para-el-vitiligo\/#Reacciones-adversas-de-monobencil-eter-de-hidroquinona\" >Reacciones adversas de monobencil \u00e9ter de hidroquinona<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/terapia-de-despigmentacion-para-el-vitiligo\/#%C2%BFComo-uso-monobencil-eter-de-hidroquinona\" >How do I use monobenzyl ether of hydroquinone?<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/terapia-de-despigmentacion-para-el-vitiligo\/#Monometil-eter-de-hidroquinona\" >Hydroquinone monomethyl ether<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/terapia-de-despigmentacion-para-el-vitiligo\/#Fenol\" >Phenol<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/terapia-de-despigmentacion-para-el-vitiligo\/#Laseres\" >Lasers<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/terapia-de-despigmentacion-para-el-vitiligo\/#Crioterapia\" >Cryotherapy<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/terapia-de-despigmentacion-para-el-vitiligo\/#Terapias-combinadas\" >Combined therapies<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/terapia-de-despigmentacion-para-el-vitiligo\/#Otros-tratamientos-potenciales-de-despigmentacion\" >Other potential depigmentation treatments<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/terapia-de-despigmentacion-para-el-vitiligo\/#Imatinib\" >Imatinib<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/terapia-de-despigmentacion-para-el-vitiligo\/#Imiquimod\" >Imiquimod<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/terapia-de-despigmentacion-para-el-vitiligo\/#Difenciprona\" >Diphencyprone<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/terapia-de-despigmentacion-para-el-vitiligo\/#Agentes-experimentales\" >experimental agents<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/terapia-de-despigmentacion-para-el-vitiligo\/#Productos-a-base-de-hierbas-y-despigmentacion\" >Herbal products and depigmentation<\/a><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n\n<h2><span class=\"ez-toc-section\" id=\"%C2%BFQuien-es-adecuado-para-la-terapia-de-despigmentacion\"><\/span>Who is suitable for depigmentation therapy?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Depigmentation therapy may be considered in the treatment of <a href=\"https:\/\/vitiligoweb.xyz\/que-es-vitiligo\/\">vitiligo<\/a> treatment resistant affecting more than 50% of the body surface area or affecting cosmetically sensitive exposed body sites.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Consentimiento-informado-para-el-tratamiento-con-agentes-despigmentantes\"><\/span>Informed consent for treatment with depigmenting agents.<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Before starting depigmentation therapy, the patient must understand:<\/p>\n<ol>\n<li>The permanent nature of the treatment.<\/li>\n<li>The need for lifelong strict sun protection to maintain benefits and reduce the risk of sun damage, including to the skin. <span class=\"term\" data-term-id=\"30\">Cancer<\/span>.<\/li>\n<li>The slow response to treatment and the need for &quot;touch-up&quot; sessions<\/li>\n<li>The potentially high cost of treatment<\/li>\n<li>Common and rare side effects and safety issues<\/li>\n<li>Risk of patchy and incomplete repigmentation<\/li>\n<li><span class=\"term\" data-term-id=\"394\">Psychosocial<\/span> and cultural issues that can arise from the change in skin color.<\/li>\n<\/ol>\n<p>Patients should have the opportunity to discuss treatment options with family and friends.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Monobencil-eter-de-hidroquinona\"><\/span>Hydroquinone monobenzyl ether<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>MBEH or monobenzone is the most commonly used depigmenting agent in vitiligo. It is the only depigmentation treatment for extensive vitiligo that has been approved by the FDA (Food and Drug Administration, United States of America).<\/p>\n<p>MBEH is a derivative of hydroquinone. Unlike hydroquinone, it almost always causes irreversible depigmentation, since it causes the death of <span class=\"term\" data-term-id=\"181\">melanocytes<\/span> (the cells that make up the skin <span class=\"term\" data-term-id=\"231\">pigment<\/span> or <span class=\"term\" data-term-id=\"180\">melanin<\/span>)<\/p>\n<p>MBEH is available as 20% <span class=\"term\" data-term-id=\"1121\">cream<\/span>, although it can be formulated up to a 40% for difficult areas like elbows and knees. In the US, it is available as Benoquin\u00ae 20% cream. MBEH is not approved by Medsafe for use in New Zealand, but doctors can obtain it from the manufacturer in Section 29. The patient must pay the full cost of treatment.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Reacciones-adversas-de-monobencil-eter-de-hidroquinona\"><\/span><span class=\"term\" data-term-id=\"1333\">Adverse reactions<\/span> hydroquinone monobenzyl ether<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Adverse reactions of MBEH are mainly mild.<\/p>\n<ul>\n<li>Transient Irritation: Discontinue treatment if burning sensation is severe.<\/li>\n<li>Contact <span class=\"term\" data-term-id=\"1168\">irritating<\/span> <span class=\"term\" data-term-id=\"53\">dermatitis<\/span> (burning, <span class=\"term\" data-term-id=\"384\">climbing<\/span>, dry skin, swelling of the treated sites): stop the treatment and apply <span class=\"term\" data-term-id=\"1330\">current<\/span> corticosteroids to the affected areas. When the dermatitis subsides, consider using a weaker strength of MBEH.<\/li>\n<li>Less often, <span class=\"term\" data-term-id=\"1204\">sensitization<\/span> or <span class=\"term\" data-term-id=\"1136\">allergy<\/span> MBEH causes allergic contact dermatitis: permanently discontinue treatment and apply topical corticosteroids to affected areas.<\/li>\n<li>Loss of color (leukoderma) in places far from the area of application of the cream.<\/li>\n<li><span class=\"term\" data-term-id=\"1095\">exogenous<\/span> Ochronosis (ash-brown pigmentation) after prolonged use of MBEH may include pigment <span class=\"term\" data-term-id=\"370\">statement<\/span> at <span class=\"term\" data-term-id=\"574\">conjunctiva<\/span> and <span class=\"term\" data-term-id=\"1032\">cornea<\/span> of the eyes<\/li>\n<li>There are no safety data available for the use of MBEH in women who may be pregnant or lactating.<\/li>\n<li>The safety of MBEH in children under 12 years of age has not been established.<\/li>\n<\/ul>\n<h3><span class=\"ez-toc-section\" id=\"%C2%BFComo-uso-monobencil-eter-de-hidroquinona\"><\/span>How do I use monobenzyl ether of hydroquinone?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<ul>\n<li>Tolerance to MBEH should be tested before starting treatment on facial skin. Apply MBEH Cream once a day for two weeks to a small area, such as the upper arm, then increase to twice a day.<\/li>\n<li>If tolerated, a thin layer of MBEH cream should be rubbed in twice daily <span class=\"term\" data-term-id=\"1520\">pigmented<\/span> areas to lighten.<\/li>\n<li>Do not apply the cream to the eyelids or <span class=\"term\" data-term-id=\"1018\">mucous membrane<\/span> surfaces<\/li>\n<li>Avoid sun exposure at all times to prevent color from returning in patches.<\/li>\n<\/ul>\n<p>Depigmentation is usually achieved after 1 to 4 months, however it can take up to 12 months to complete depigmentation of a particular site.<\/p>\n<p>Treatment should be discontinued if desired results are not achieved after 4 months of use. Once the desired degree of depigmentation is achieved, the cream can be applied intermittently to maintain this, usually twice a week.<\/p>\n<p>After treatment, white skin will be sensitive to the sun for a lifetime. Apply broad spectrum SPF50+ sunscreen to all fair skin at least daily.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Monometil-eter-de-hidroquinona\"><\/span>Hydroquinone monomethyl ether<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Monomethyl ether of hydroquinone (MMEH) is also known as 4-methoxyphenol, mequinol, or p-hydroxyanisole.<\/p>\n<ol>\n<li>MMEH has similar melanocytotoxic properties to MBEH.<\/li>\n<li>MMEH is generally compounded as a cream to 20%.<\/li>\n<li>MMEH is applied in a similar way to MBEH.<\/li>\n<li>Compared to MBEH, MMEH takes longer to achieve depigmentation, typically 4-12 months.<\/li>\n<li>Skin irritation from MMEH is less common and less severe than with MBEH.<\/li>\n<\/ol>\n<h2><span class=\"ez-toc-section\" id=\"Fenol\"><\/span>Phenol<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Phenol is relatively cheap. It has traditionally been used for deep chemical peels. phenol is <span class=\"term\" data-term-id=\"1159\">toxic<\/span> melanocytes, and prevents them from synthesizing melanin. High doses of phenol (eg, 88%) are also systemically toxic and should not be applied to large areas. It should be used with great caution because it can cause severe chemical burns, heart <span class=\"term\" data-term-id=\"1134\">arrhythmias<\/span> and other dangers<\/p>\n<p>Phenol is used to treat small areas of persistent pigment in vitiligo, i.e. &lt;20% of the face or neck area. For safety, use only 0.5-1 ml per session and the duration of the application should not exceed 60 minutes. Phenol must be applied by an experienced physician.<\/p>\n<ul>\n<li>Clean the skin with alcohol.<\/li>\n<li>Apply a cotton swab moistened with phenol to treat small areas until glazed.<\/li>\n<li>The maximum amount allowed per session is 1 ml.<\/li>\n<li>A burning sensation lasts about a minute and gradually decreases in intensity over minutes to hours.<\/li>\n<li>Two treatments given 6 weeks apart are usually sufficient.<\/li>\n<li>Post-procedure care includes the normal <span class=\"term\" data-term-id=\"1875\">saline<\/span> soaks and mild to moderate topical corticosteroids.<\/li>\n<\/ul>\n<p>Side effects and risks of phenol include:<\/p>\n<ul>\n<li>Scars<\/li>\n<li>Dyschromia (irregular pigmentation\/depigmentation)<\/li>\n<li><span class=\"term\" data-term-id=\"324\">Located<\/span> or <span class=\"term\" data-term-id=\"67\">disseminated<\/span> herpes simplex virus <span class=\"term\" data-term-id=\"145\">infection<\/span>. antiviral <span class=\"term\" data-term-id=\"1737\">prophylaxis<\/span> with acyclovir should be considered.<\/li>\n<li>Corrosion of any tissue with which it comes into contact, for <span class=\"term\" data-term-id=\"1355\">inhalation<\/span>, <span class=\"term\" data-term-id=\"406\">ingestion<\/span>or direct skin contact.<\/li>\n<li>The concentration of 88% rapidly coagulates the <span class=\"term\" data-term-id=\"85\">epidermis<\/span> and therefore prevents its own percutaneous penetration, compared to traditional 40-50% phenol peels.<\/li>\n<li><span class=\"term\" data-term-id=\"380\">Systemic<\/span> <span class=\"term\" data-term-id=\"1160\">toxicity<\/span> results in cardiovascular shock, cardiac arrhythmias, <span class=\"term\" data-term-id=\"1132\">bradycardia<\/span>and metabolic acidosis. These have been reported within 6 hours of phenol peeling procedures.<\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"Laseres\"><\/span>Lasers<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span class=\"term\" data-term-id=\"1405\">Q-Switched<\/span> lasers, such as ruby (694nm), alexandrite (755nm), and Nd:YAG (532nm and 1064nm) can be used alone or in combination with topical depigmenting agents such as MBEH or MMEH. These lasers work as depigmenting agents by selectively destroying melanin and melanin-containing cells.<\/p>\n<p>The main disadvantages of lasers in depigmentation therapy are:<\/p>\n<ul>\n<li>High price<\/li>\n<li>Possible need for local anesthetics due to pain.<\/li>\n<li>Possible treatment failure<\/li>\n<li><span class=\"term\" data-term-id=\"1074\">Reappearance<\/span> pigmentation<\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"Crioterapia\"><\/span><span class=\"term\" data-term-id=\"1145\">Cryotherapy<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Liquid nitrogen cryotherapy is a cost-effective permanent depigmentation treatment when rapid depigmentation of a small area is desired. It is simple, easy for an experienced clinician to perform, and requires only a short preparation time. Melanocytes are extremely sensitive to cryogenic damage compared to <span class=\"term\" data-term-id=\"1069\">keratinocytes<\/span> and cryotherapy can cause permanent loss of color (depigmentation) after treatment.<\/p>\n<ul>\n<li>Single freeze-thaw cycles of 10-20 seconds are recommended, although one study has used two freeze-thaw cycles.<\/li>\n<li>Various techniques are described, including the use of a cryoprobe held approximately 40 mm from the skin.<\/li>\n<li>The best cosmetic results are usually seen 4 weeks after cryotherapy.<\/li>\n<li>The procedure may need to be repeated at 4-6 week intervals for partially depigmented lesions until complete depigmentation occurs.<\/li>\n<\/ul>\n<p>The disadvantages of cryotherapy include:<\/p>\n<ul>\n<li>Pain<\/li>\n<li>Not suitable for large pigmented areas.<\/li>\n<li>Dyschromia (irregular pigmentation\/depigmentation)<\/li>\n<li>Recurrence of pigmentation<\/li>\n<li>Scarring (rare).<\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"Terapias-combinadas\"><\/span>Combined therapies<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>There are some reports that MBEH or MMEH combine with a topical <span class=\"term\" data-term-id=\"761\">retinoid<\/span> how tretinoin can overcome treatment resistance and improve treatment <span class=\"term\" data-term-id=\"914\">effectiveness<\/span>. <span class=\"term\" data-term-id=\"762\">Retinoids<\/span> help by inhibiting <span class=\"term\" data-term-id=\"784\">melanocyte<\/span> <span class=\"term\" data-term-id=\"1525\">enzyme<\/span> glutathione S-transferase.<\/p>\n<p>MBEH or MMEH can also be used in combination with cryotherapy, or <span class=\"term\" data-term-id=\"1617\">To be<\/span> treatment.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Otros-tratamientos-potenciales-de-despigmentacion\"><\/span>Other potential depigmentation treatments<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h3><span class=\"ez-toc-section\" id=\"Imatinib\"><\/span>Imatinib<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Imatinib is a drug used to <span class=\"term\" data-term-id=\"319\">chronic<\/span> <span class=\"term\" data-term-id=\"1896\">myeloid<\/span> <span class=\"term\" data-term-id=\"613\">leukemia<\/span>, where skin depigmentation has been reported as a side effect within 4-12 weeks of receiving this medication. The suggested mechanism of action is that imatinib mesylate, a <span class=\"term\" data-term-id=\"624\">tyrosine kinase<\/span> inhibitor, interferes with the production of melanin.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Imiquimod\"><\/span>Imiquimod<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Imiquimod is an immune response modifier, most often used in the treatment of superficial skin cancers and genital warts. One of the side effects of treatment is sometimes permanent. <span class=\"term\" data-term-id=\"139\">hypopigmentation<\/span>, which may occur after 3 months of treatment. The postulated mechanism of action is that imiquimod can induce <span class=\"term\" data-term-id=\"13\">apoptosis<\/span> of melanocytes<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Difenciprona\"><\/span>Diphencyprone<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Diphencyprone, also called diphenylcyclopropenone, is used in <span class=\"term\" data-term-id=\"55\">dermatology<\/span> to treat conditions with alterations <span class=\"term\" data-term-id=\"464\">immune <\/span>states, such as <span class=\"term\" data-term-id=\"824\">alopecia<\/span> areata. Diphencyprone solution has been observed to sometimes result in hypopigmentation or complete depigmentation in treated areas, possibly due to its <span class=\"term\" data-term-id=\"680\">immunomodulator<\/span> Effects Onset of depigmentation is reported to occur after 10 months, and can occur even at concentrations as low as 0.0001%.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Agentes-experimentales\"><\/span>experimental agents<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Several phenolic compounds, including hydroquinone in concentrations higher than 4%, 4-ethoxyphenol, and 4-methylcatechol, are being tested for their depigmenting effects in animals and show promise. There is some suggestion that IFN-\u03b3, busulfan, and some <span class=\"term\" data-term-id=\"1670\">melanoma<\/span> Vaccines (immunotherapy) have depigmenting activity.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Productos-a-base-de-hierbas-y-despigmentacion\"><\/span>Herbal products and depigmentation<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>The most common herbs used by traditional healers for voluntary depigmentation in Africa are:<\/p>\n<ul>\n<li>Brillantaisia \u200b\u200bcicatricosa Lindau (Acanthaceae)<\/li>\n<li>Chenopodium ugandae (Aellen) Aellen (Chenopodiaceae)<\/li>\n<li>Dolichopentas longiflora Oliv. (Rubiaceae)<\/li>\n<li>Protea madiensis Oliv. (Proteaceae)<\/li>\n<li>Sesamum angolense Welw. (Pedaliaceae).<\/li>\n<li>Ethanol extracts from the leaves of Myrica rubra.<\/li>\n<\/ul>\n<p>In vitro studies have indicated that these herbs may have effects on melanin production by melanocytes. This represents a potential area for future studies.<\/p>\n<\/section>","protected":false},"excerpt":{"rendered":"<p>\u00bfQu\u00e9 es el vitiligo? El vitiligo es un trastorno com\u00fan de la piel que resulta en p\u00e9rdida parcial de pigmentaci\u00f3n, es decir, manchas blancas de piel. \u00bfQui\u00e9n es adecuado para&#8230;<\/p>","protected":false},"author":8,"featured_media":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","format":"standard","meta":{"footnotes":""},"categories":[204],"tags":[],"class_list":["post-7890","wiki","type-wiki","status-publish","format-standard","category-glosario-definiciones"],"_links":{"self":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/7890","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki"}],"about":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/types\/wiki"}],"author":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/comments?post=7890"}],"version-history":[{"count":0,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/7890\/revisions"}],"wp:attachment":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/media?parent=7890"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/categories?post=7890"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/tags?post=7890"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}