<\/span><\/h2>\nCurrent<\/span> 3% diclofenac gel in 2.5% hyaluronic acid (Solaraze\u00ae, Bioglan Pharma, Florida, USA) is used as a field treatment for actinic keratosis<\/span><\/span> (AK) It is available in the US, Canada, and several European Union countries, but is not marketed in New Zealand (2015).<\/p>\n<\/span>How does diclofenac gel work?<\/span><\/h2>\nThe active ingredient in the gel, diclofenac sodium, is a non-steroidal anti-steroid.inflammatory<\/span> drug (NSAID<\/span>) NSAID<\/span> provide anti-inflammatory<\/span> and anti-neoplastic<\/span><\/span> (anti-Cancer<\/span>) Benefits.<\/p>\n\n- How diclofenac gel works in the treatment of AK is not fully understood.<\/li>\n
- Diclofenac is a powerful inhibitor of inducible<\/span> cyclooxygenase (COX-2), resulting in reduced prostaglandin synthesis.<\/li>\n
- Sun damage and AKs have been linked to elevated prostaglandins in exposed skin<\/span>.<\/li>\n<\/ul>\n
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<\/span>How is diclofenac gel given?<\/span><\/h2>\nTreatment is usually done during the winter months. Diclofenac gel is for use on the skin only and contact with the eyes should be avoided.<\/p>\n
\n- The gel should be stored at room temperature.<\/li>\n
- Determine which areas should be treated with diclofenac gel. The amount of diclofenac gel needed depends on the size of the injury<\/span> site.<\/li>\n
- Typically 0.5 g of gel (one finger unit) is used at each 5 cm x 5 cm site of injury.<\/li>\n
- No additional gel should be applied if an application is missed.<\/li>\n
- The gel is applied twice a day for 60 to 90 days and then suspended.<\/li>\n<\/ul>\n
<\/span>After treatment<\/span><\/h3>\n