<\/span><\/h2>\nDowling-Degos disease is a autosomal<\/span> dominant skin disorder characterized by progressive<\/span> pigmentation<\/span> of the skin within the folds of the body. Association with loss of function mutations<\/span> in KRT5 (encoding curb<\/span> 5) is documented.<\/p>\n<\/span>\nHistology<\/span> of Dowling-Degos disease<\/span><\/h2>\nEpidermal<\/span> changes in Dowling-Degos disease include hyperkeratosis<\/span>, often with small horn<\/span> cysts and thinning of the suprapapillary epidermis<\/span>. Slim epithelial<\/span> the threads extend towards the surface dermis<\/span> of the epidermis and hair<\/span> follicles<\/span> resulting in a \u201chorn\u201d pattern (Figures 1, 2). Epidermal hyperpigmentation<\/span> It is common although rarepigmented<\/span> Variants are reported. Hair follicle<\/span> infundibulum<\/span> may be dilated Dermal<\/span> perivascular<\/span> lymphohistiocytic<\/span> infiltrate<\/span> (figures 1,2,3) or a lichenoid<\/span> A tissue reaction pattern can be observed.<\/p>\n\n<\/span>Pathology of Dowling-Degos disease<\/span><\/h5>\n<\/section>\n\n\n
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Figure 1<\/p>\n
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Figure 2<\/p>\n
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figure 3<\/p>\n<\/p><\/div>\n<\/section>\n
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<\/span>\nDifferential diagnosis<\/span> of Dowling-Degos disease<\/span><\/h2>\nGalli-Galli disease is a subtype of Dowling-Degos disease and is distinguished by the additional finding ofdyskeratotic<\/span> acantholysis<\/span> (Figure 3, arrow). Other clinics and histological<\/span> The characteristics are identical to Dowling-Degos disease.<\/p>\nSeborrheic<\/span> keratosis<\/span> - in Dowling-Degos disease<\/span>, epithelial strands extend from the epidermis and hair follicles. The clinical presentation is very useful to differentiate these conditions.<\/p>\nTo have syndrome<\/span> \u2013 histological characteristics shared with Dowling-Degos disease;<\/span> however, the clinical presentation is different with facial rosacea-like lesions, pitted scars, and seborrheic keratosis-like lesions on the trunk and push-ups<\/span>. Haber syndrome is not associated with keratin 5 mutations.<\/p>\n<\/section>","protected":false},"excerpt":{"rendered":"Introducci\u00f3n La enfermedad de Dowling-Degos es un autos\u00f3mico trastorno de la piel dominante caracterizado por progresivo pigmentaci\u00f3n de la piel dentro de los pliegues del cuerpo. Asociaci\u00f3n con p\u00e9rdida de…<\/p>","protected":false},"author":8,"featured_media":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","format":"standard","meta":{"footnotes":""},"categories":[204],"tags":[205],"class_list":["post-7966","wiki","type-wiki","status-publish","format-standard","category-glosario-definiciones","tag-patologia"],"_links":{"self":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/7966","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki"}],"about":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/types\/wiki"}],"author":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/comments?post=7966"}],"version-history":[{"count":0,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/7966\/revisions"}],"wp:attachment":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/media?parent=7966"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/categories?post=7966"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/tags?post=7966"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}