{"id":7976,"date":"2020-04-26T15:39:36","date_gmt":"2020-04-26T18:39:36","guid":{"rendered":"https:\/\/doctorhoogstra.com\/es\/penfigo-inducido-por-farmacos\/"},"modified":"2020-10-30T07:24:24","modified_gmt":"2020-10-30T10:24:24","slug":"drug-induced-pemphigus","status":"publish","type":"wiki","link":"https:\/\/doctorhoogstra.com\/en\/wiki\/penfigo-inducido-por-farmacos\/","title":{"rendered":"Drug-induced pemphigus"},"content":{"rendered":"<p><\/p><div id=\"ez-toc-container\" class=\"ez-toc-v2_0_89 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 eztoc-toggle-hide-by-default' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/penfigo-inducido-por-farmacos\/#%C2%BFQue-es-el-penfigo\" >What is pemphigus?<\/a><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/penfigo-inducido-por-farmacos\/#Formas-de-penfigo\" >Forms of pemphigus<\/a><\/li><\/ul><\/li><\/ul><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/penfigo-inducido-por-farmacos\/#%C2%BFQue-es-el-penfigo-inducido-por-drogas\" >What is drug-induced pemphigus?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/penfigo-inducido-por-farmacos\/#%C2%BFQuien-contrae-penfigo-inducido-por-drogas\" >Who gets drug-induced pemphigus?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/penfigo-inducido-por-farmacos\/#%C2%BFQue-causa-el-penfigo-inducido-por-drogas\" >What causes drug-induced pemphigus?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/penfigo-inducido-por-farmacos\/#%C2%BFCuales-son-las-caracteristicas-clinicas-del-penfigo-inducido-por-farmacos\" >What are the clinical characteristics of drug-induced pemphigus?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/penfigo-inducido-por-farmacos\/#%C2%BFComo-se-diagnostica-el-penfigo-inducido-por-farmacos\" >How is drug-induced pemphigus diagnosed?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/penfigo-inducido-por-farmacos\/#%C2%BFComo-se-trata-el-penfigo-inducido-por-farmacos\" >How is drug-induced pemphigus treated?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/penfigo-inducido-por-farmacos\/#%C2%BFCual-es-el-resultado-para-el-penfigo-inducido-por-drogas\" >What is the outcome for drug-induced pemphigus?<\/a><\/li><\/ul><\/nav><\/div>\n\n<section class=\"textBlock\">\n<h2><span class=\"ez-toc-section\" id=\"%C2%BFQue-es-el-penfigo\"><\/span>What is pemphigus?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Pemphigus refers to a group of <span class=\"term\" data-term-id=\"691\">autoimmune<\/span> diseases that cause blisters. Pemphigus is characterized by the development of <span class=\"term\" data-term-id=\"426\">antibodies<\/span> directed against a protein (either <span class=\"term\" data-term-id=\"1030\">desmoglein<\/span> 1, desmoglein 3 or both) involved in cell-cell adhesion in the <span class=\"term\" data-term-id=\"85\">epidermis<\/span>.<\/p>\n<p>Types of pemphigus include:<\/p>\n<ul>\n<ul>\n<li>Pemphigus vulgaris<\/li>\n<li>Leaf Pemphigus<\/li>\n<li><span class=\"term\" data-term-id=\"22\">Benign<\/span> <span class=\"term\" data-term-id=\"849\">family<\/span> <a class=\"wpil_keyword_link\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/penfigo\/\" title=\"pemphigus\">pemphigus<\/a> (Hailey \u2013 Hailey disease) <\/li>\n<li>Pemphigus erythematosus<\/li>\n<li><span class=\"term\" data-term-id=\"219\">Paraneoplastic<\/span> pemphigus<\/li>\n<li>Drug-induced pemphigus.<\/li>\n<\/ul>\n<\/ul>\n<section class=\"textBlock imageLinkBlockTitle\">\n<h5 class=\"colour--primary\"><span class=\"ez-toc-section\" id=\"Formas-de-penfigo\"><\/span>Forms of pemphigus<span class=\"ez-toc-section-end\"><\/span><\/h5>\n<\/section>\n<section class=\"imageLinkBlock\">\n<div class=\"flex\">\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='pemphigus-drug-101__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-7205959-8473868' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/pemphigus-drug-101__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-7205959.jpg'>\n<\/div>\n<p class=\"p-small\">Drug-induced pemphigus foliaceus<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='pemphigus-foliaceus-125__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-7084499-7972995' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/pemphigus-foliaceus-125__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-7084499.jpg'>\n<\/div>\n<p class=\"p-small\">Leaf Pemphigus<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='pemphigus-vulgaris-100__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-3469765-4253895' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/pemphigus-vulgaris-100__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-3469765.jpg'>\n<\/div>\n<p class=\"p-small\">Pemphigus vulgaris<\/p>\n<\/p><\/div>\n<\/section>\n<div class=\"clearfix imageLinkBlock\"><\/div>\n<h2><span class=\"ez-toc-section\" id=\"%C2%BFQue-es-el-penfigo-inducido-por-drogas\"><\/span>What is drug-induced pemphigus?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Drug-induced pemphigus is diagnosed when a form of pemphigus has been detected <span class=\"term\" data-term-id=\"1497\">precipitate<\/span> due to a medication Pemphigus may appear days, weeks, or up to 6 months after the medication has been started.<\/p>\n<div id=\"square-placement-country-holder\" class=\"country-dependent advert\">\n<div class=\"box-placement square-placement\">\n<div class=\"advert__frame\">\n<div id=\"dermnet-dermnet-mobbox\">\n<\/div><\/div><\/div><\/div>\n<h2><span class=\"ez-toc-section\" id=\"%C2%BFQuien-contrae-penfigo-inducido-por-drogas\"><\/span>Who gets drug-induced pemphigus?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>More than 200 cases of drug-induced pemphigus have been reported in the medical literature. Reports suggest that patients with drug-induced pemphigus may have features similar to non-drug-induced pemphigus.<\/p>\n<ul>\n<li>Race: Pemphigus may be more common in Jews of Ashkenazi descent<\/li>\n<li>\n<span class=\"term\" data-term-id=\"1167\">Sex<\/span> \u2013 more cases were seen in women than in men in some studies<\/li>\n<li>Age: Most literature reports cases seen in individuals between the ages of 30 and 90 years.<\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"%C2%BFQue-causa-el-penfigo-inducido-por-drogas\"><\/span>What causes drug-induced pemphigus?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Medicines that cause pemphigus include:<\/p>\n<ul>\n<li>Thiol drugs, including penicillamine, captopril<\/li>\n<li>\n<p>Antibiotics: penicillins, cephalosporins, vancomycin.<\/li>\n<li>Antihypertensive medications: other angiotensin converters <span class=\"term\" data-term-id=\"1525\">enzyme<\/span> inhibitors such as cilazapril, lisinopril, enalapril<\/li>\n<li>Piroxicam.<\/li>\n<\/ul>\n<p>Drug-induced pemphigus is usually caused by the induction of an immune reaction to desmoglein proteins and is identical to <span class=\"term\" data-term-id=\"862\">idiopathic<\/span> forms of pemphigus In some cases, when antibodies against desmoglein have not been detected, a biochemical cause for drug-induced pemphigus is suspected.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%C2%BFCuales-son-las-caracteristicas-clinicas-del-penfigo-inducido-por-farmacos\"><\/span>What are the clinical characteristics of drug-induced pemphigus?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Clinical features depend on whether drug-induced pemphigus has been induced by thiol or non-thiol drugs.<\/p>\n<p>Thiol medications cause pemphigus foliaceus.<\/p>\n<ul>\n<li>Pemphigus foliaceus presents with <span class=\"term\" data-term-id=\"967\">erythematous<\/span>, <span class=\"term\" data-term-id=\"385\">scaly<\/span> or crusted <span class=\"term\" data-term-id=\"368\">plates<\/span>.<\/li>\n<li>\n<span class=\"term\" data-term-id=\"1028\">Vesicles<\/span>, <span class=\"term\" data-term-id=\"499\">bullas<\/span> and <span class=\"term\" data-term-id=\"536\">erosions<\/span> may or may not be present.<\/li>\n<li>It most often affects the trunk.<\/li>\n<li>Oral <span class=\"term\" data-term-id=\"189\">mucous membrane<\/span> He is not involved.<\/li>\n<\/ul>\n<p>Non-thiol medications most commonly cause pemphigus vulgaris.<\/p>\n<ul>\n<li>Pemphigus vulgaris presents with pain <span class=\"term\" data-term-id=\"1627\">flaccid<\/span> vesicles and blisters.<\/li>\n<li>It affects the scalp, face and trunk.<\/li>\n<li>The blisters can affect the oral mucosa.<\/li>\n<\/ul>\n<div id=\"square-placement-country-holder\" class=\"country-dependent advert\">\n<div class=\"box-placement square-placement\">\n<div class=\"advert__frame\">\n<div id=\"dermnet-dermnet-mobbox\">\n<\/div><\/div><\/div><\/div>\n<h2><span class=\"ez-toc-section\" id=\"%C2%BFComo-se-diagnostica-el-penfigo-inducido-por-farmacos\"><\/span>How is drug-induced pemphigus diagnosed?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The diagnosis of drug-induced pemphigus can be challenging, especially in patients on multiple drugs such as the period between <span class=\"term\" data-term-id=\"406\">ingestion<\/span> of the <span class=\"term\" data-term-id=\"1714\">causal drug<\/span> and the onset of symptoms may be prolonged. Careful and thorough taking of history is vital.<\/p>\n<p>The diagnosis of pemphigus is confirmed by its characteristic <span class=\"term\" data-term-id=\"1038\">intraepidermal<\/span> blisters when seen on <span class=\"term\" data-term-id=\"128\">histology<\/span> of a skin <span class=\"term\" data-term-id=\"24\">biopsy<\/span>and the presence of typical antibodies in direct <span class=\"term\" data-term-id=\"142\">immunofluorescence<\/span>. Circulating pemphigus antibodies against desmoglein 1 and\/or desmoglein 3 can be detected in <span class=\"term\" data-term-id=\"621\">serology<\/span>.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%C2%BFComo-se-trata-el-penfigo-inducido-por-farmacos\"><\/span>How is drug-induced pemphigus treated?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Management of drug-induced pemphigus includes:<\/p>\n<ul>\n<li>Withdrawal of the offending drug<\/li>\n<li><span class=\"term\" data-term-id=\"380\">Systemic<\/span> corticosteroids<\/li>\n<li>\n<p>Immunosuppressive drugs.<\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"%C2%BFCual-es-el-resultado-para-el-penfigo-inducido-por-drogas\"><\/span>What is the outcome for drug-induced pemphigus?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The outcome of drug-induced pemphigus depends on whether the patient has developed antibodies and whether the cause of the condition is a thiol or non-thiol drug.<\/p>\n<ul>\n<li>Patients whose pemphigus has been induced by non-thiol drugs and have detected antibodies have better <span class=\"term\" data-term-id=\"241\">forecast<\/span>.<\/li>\n<li>About 50% of thiol-induced cases will resolve when the offending drug is discontinued.<\/li>\n<\/ul>\n<\/section>","protected":false},"excerpt":{"rendered":"<p>What is pemphigus? Pemphigus refers to a group of autoimmune diseases that cause blisters. Pemphigus is characterized by the development of antibodies directed against a protein (either...<\/p>","protected":false},"author":8,"featured_media":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","format":"standard","meta":{"footnotes":""},"categories":[204],"tags":[],"class_list":["post-7976","wiki","type-wiki","status-publish","format-standard","category-glosario-definiciones"],"_links":{"self":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/7976","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki"}],"about":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/types\/wiki"}],"author":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/comments?post=7976"}],"version-history":[{"count":0,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/7976\/revisions"}],"wp:attachment":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/media?parent=7976"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/categories?post=7976"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/tags?post=7976"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}