<\/span><\/h2>\nEosinophilic dermatosis from hematologic or hematologic malignancy (blood Cancer<\/span>) is a rare skin eruption<\/span> seen in patients with underlying hematologic malignancy. First rated as overkill arthropod<\/span> bites like clinic and histological<\/span> Features resemble arthropod bites, with prominent eosinophilia<\/span> (greater number of eosinophils<\/span>)<\/p>\n<\/span>What is a eosinophils<\/span>?<\/span><\/h2>\nAn eosinophil is a type of white blood cell produced by the bone marrow. It is characterized by thick granules<\/span> inside the cell cytoplasm<\/span>. The functions of eosinophils include:<\/p>\n\n- Antiparasitic activity<\/li>\n
- \nBactericide<\/span> exercise<\/li>\n
- Modulation of inflammatory<\/span> reply<\/li>\n
- Participation in allergic reactions<\/span>.<\/li>\n<\/ul>\n
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<\/span>Who gets eosinophilic dermatosis from hematologic malignancy?<\/span><\/h2>\nPeople with underlying hematologic malignancies, in particular, chronic<\/span> lymphocytic<\/span> leukemia<\/span> (CLL). Less frequently, the condition has been documented in patients with acute<\/span> myelocytic leukemia, acute lymphocytic leukemia, mantle cells lymphoma<\/span> and multiple myeloma.<\/p>\nThe skin rash can occur at the same time, before or after the diagnosis of the underlying hematologic malignancy.<\/p>\n
<\/span>What are the clinical features of eosinophilic dermatosis from hematologic malignancy?<\/span><\/h2>\nThe diagnosis of eosinophilic dermatosis of hematological neoplasia is made using the following characteristics:<\/p>\n
\n- Small, dome-shaped, recurring, itchy bumps or tender bumps (papules<\/span>) and packages (nodules<\/span>)<\/li>\n
- Hivesurticarial<\/span> cure<\/span>)<\/li>\n
- Variable size fluid filled ampoules (vesicles<\/span>and bullas<\/span>)<\/li>\n
- Involvement of exposed and unexposed body sites.<\/li>\n<\/ul>\n\n
<\/span>Eosinophilic dermatosis of hematologic malignancy.<\/span><\/h5>\n<\/section>\n\n\n
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Eosinophilic dermatosis of hematologic malignancy.<\/p>\n
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Eosinophilic dermatosis of hematologic malignancy.<\/p>\n
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Eosinophilic dermatosis of hematologic malignancy.<\/p>\n
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Eosinophilic dermatosis of hematologic malignancy.<\/p>\n<\/p><\/div>\n<\/section>\n
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<\/span>What causes eosinophilic dermatosis from hematologic malignancy?<\/span><\/h2>\nThe exact cause of eosinophilic dermatosis from hematologic malignancy is poorly understood. A proposed theory is that the underlying cancer causes immunity deregulation<\/span>. This leads to an imbalance in the production of cytokines<\/span> (messenger proteins), with a higher production of interleukin<\/span>-5 (IL-5). IL-5 recruits eosinophils into the skin.<\/p>\n\n
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<\/span>How was the diagnosis made?<\/span><\/h2>\nThe diagnosis of eosinophilic dermatosis of hematologic malignancy is based on the following diagnostic criteria:<\/p>\n
\n- Papules, nodules and \/ or itching. vesiculobullous<\/span> eruption<\/li>\n
- There is no discernible relationship with outdoor activity.<\/li>\n
- In biopsy<\/span>rich in eosinophils lymphohistiocytic<\/span> infiltrate<\/span> in shallow and deep dermis<\/span> with or without flame figures (these are granules of extracellular eosinophils that cover collagen<\/span> fibers in the dermis)<\/li>\n
- Exclusion of other causes of tissue eosinophilia (such as drug reaction, insect sting reaction, eosinophilic folliculitis, and Wells syndrome<\/span>)<\/li>\n
- Pre-existing diagnosis of a hematological neoplasm or its subsequent development.<\/li>\n<\/ul>\n
<\/span>What is the treatment for hematologic malignancy eosinophilic dermatosis?<\/span><\/h2>\nVarious treatments have been used to treat eosinophilic dermatosis from hematologic malignancies, but they have been reported to be largely disappointing. They include:<\/p>\n
\n- \nCurrent<\/span> and systemic<\/span> corticosteroids\n<\/li>\n
- Phototherapy<\/li>\n
- Antihistamines<\/li>\n
- Dapsone<\/li>\n
- Alpha interferon<\/li>\n
- Intravenous immunoglobulin<\/span> (IVIg)<\/li>\n
- \nChemotherapy<\/span>.<\/li>\n<\/ul>\n
It is not clear whether eosinophilic dermatosis from hematologic malignancy may have forecast<\/span> implication. Some studies have suggested that patients with eosinophilic dermatosis of hematologic malignancy perform poorly compared to those with the same hematologic malignancy but without the skin condition.<\/p>\n<\/section>","protected":false},"excerpt":{"rendered":"Que es eosinof\u00edlica dermatosis de hematol\u00f3gico malignidad? Dermatosis eosinof\u00edlica de neoplasia hematol\u00f3gica o hematol\u00f3gica (sangre c\u00e1ncer) es una piel rara erupci\u00f3n visto en pacientes con neoplasia hematol\u00f3gica subyacente. Primero se…<\/p>","protected":false},"author":8,"featured_media":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","format":"standard","meta":{"footnotes":""},"categories":[204],"tags":[],"class_list":["post-8055","wiki","type-wiki","status-publish","format-standard","category-glosario-definiciones"],"_links":{"self":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/8055","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki"}],"about":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/types\/wiki"}],"author":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/comments?post=8055"}],"version-history":[{"count":0,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/8055\/revisions"}],"wp:attachment":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/media?parent=8055"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/categories?post=8055"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/tags?post=8055"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}