Infections such as impetigo or boils.<\/li>\n<\/ul>\nErythromycin is particularly useful in individuals allergic to penicillin and in children who are too young for a tetracycline.<\/p>\n
It is active against many gram-positive ones. organisms<\/span> (even Staphylococcus aureus<\/em>, Streptococcus pyogenes<\/em>, corynebacteria and clostridia) and some gram-negative organisms (Neisseria gonorrhoeae<\/em>, the cause of gonorrhea). It is also effective for mycoplasma, syphilis, and chlamydia infections.<\/p>\nGrowing bacterial<\/span> Erythromycin resistance is reported. Long-term use of erythromycin has been questioned in dermatology<\/span> because it can lead to bacterial resistance to pathogen<\/span>, Staphylococcus aureus<\/em> (See MRSA), as well as acne resistance bacteria<\/span> (Cutibacterium acnes<\/em>)<\/p>\n\n
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<\/span>How does erythromycin work in skin diseases?<\/span><\/h2>\n\n- Erythromycin has bacteriostatic effects and prevents proliferation<\/span> bacteria<\/li>\n
- Inhibits the pro-inflammatory<\/span> cytokines<\/span> as IL-8 and decreases neutrophils<\/span> oxidative explosions<\/li>\n<\/ul>\n
<\/span>How is erythromycin taken?<\/span><\/h2>\nOral erythromycin is best taken on an empty stomach or just before meals. It comes in a number of bases and formulations.<\/p>\n
\n- Base compound<\/li>\n
- Salt stolate<\/li>\n
- Ethyl succinate salt<\/li>\n
- Stearate salt<\/li>\n<\/ul>\n
Also available as current<\/span> acne prep.To reduce antibiotic resistance, a non-antibiotic compound such as benzoyl peroxide or a topical retinoid<\/span> should be applied when topical erythromycin is used.<\/p>\n<\/span>What are the side effects of erythromycin?<\/span><\/h2>\nErythromycin is generally well tolerated. When essential, erythromycin can be used in pregnancy and during lactation.<\/p>\n
The following side effects can arise.<\/p>\n
\n- Gastrointestinal disorders: nausea, vomiting, abdominal pain, diarrhea, loss of appetite.<\/li>\n
- Hepatic reactions: more common in people with pre-existing and potentially serious liver disease. The signs are dark urine, light stools, yellow eyes and skin (jaundice<\/span>)<\/li>\n
- Allergic rashes: urticaria, fixed drug eruption<\/span>Stevens-Johnson\u2013toxic<\/span> epidermal<\/span> necrolysis and rarely, anaphylaxis<\/span>\n<\/li>\n
- Hearing loss - more likely with high doses in people with kidney disease<\/li>\n
- Potentially deadly arrhythmias<\/span> (irregularities of the heartbeat) have been reported in people with dysfunction<\/span> that results in a prolonged QT interval on the electrocardiograph (ECG). This may be due to congenital<\/span> or acquired heart conditions or electrolyte disturbances (low levels of potassium or magnesium)<\/li>\n<\/ul>\n
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<\/span>Drug interactions with erythromycin<\/span><\/h2>\nErythromycin has significant interactions with other medications. Tell your doctor the names of all the medications you are taking, whether prescription or over-the-counter.<\/p>\n