\nFlegel's disease is rare skin disease<\/span> characterized by asymptomatic<\/span> hyperkeratotic<\/span> papules<\/span> predominantly on the back of the feet and legs. Clinical input is often very helpful in making a diagnosis. histopathologically<\/span>. The disorder is believed to be caused by disturbances in the lining of the membrane. granules<\/span> (lamellar granules, bodies of Odland) of the keratinocytes<\/span><\/p>\n<\/span>\nHistology<\/span> of hyperkeratosis<\/span> lenticularis perstans (Flegel's disease)<\/span><\/h2>\nIn Flegel's disease, sections show discreet<\/span> areas of compact lamellar hyperkeratosis with focal<\/span> parakeratosis<\/span> (Figure 1). the epidermis<\/span> underneath hyperkeratosis is atrophic<\/span> compared to the surrounding skin, and the granular layer<\/span> it is dimmed absent (figure 2). The papillary dermis<\/span> contains a dense band infiltrate<\/span> composed of small lymphocytes<\/span> interspersed with histiocytes<\/span>. Vasodilation<\/span> Superficial vessels are also seen (Figure 3).<\/p>\n\n<\/span>Pathology of lenticular hyperkeratosis perstans (Flegel's disease)<\/span><\/h5>\n<\/section>\n\n\n
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Figure 1<\/p>\n
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Figure 2<\/p>\n
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figure 3<\/p>\n<\/p><\/div>\n<\/section>\n
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<\/span>Special studies for lenticular hyperkeratosis perstans (Flegel's disease)<\/span><\/h2>\nGenerally none is needed. Examination of membrane coating granules by electon microscopy<\/span> It is commonly reported in the literature, but is not considered useful for diagnosis.<\/p>\n\n
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<\/span>\nDifferential diagnosis<\/span> of lenticular hyperkeratosis perstans (Flegel's disease) pathology<\/span>
\n<\/span><\/h2>\nKyrle's disease: This condition is clinically similar and may share some pathogen<\/span> components. Kyrle's disease should exhibit impressive curb<\/span> plug and inflammatory<\/span> perforating material through the epidermis.<\/p>\nPorokeratosis Cornoids<\/span> the blades allow easy diagnosis of this condition<\/p>\nActinic keratosis<\/span><\/span> - actinic dysplasia<\/span><\/span> is seen. Some authors believe that Flegel's disease is an incipient form epidermal<\/span> dysplasia<\/p>\n<\/section>","protected":false},"excerpt":{"rendered":"La enfermedad de Flegel es rara dermatosis caracterizado por asintom\u00e1tico hiperquerat\u00f3tico p\u00e1pulas predominantemente en la dorsa de los pies y piernas. El aporte cl\u00ednico a menudo es muy \u00fatil para…<\/p>","protected":false},"author":8,"featured_media":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","format":"standard","meta":{"footnotes":""},"categories":[204],"tags":[205],"class_list":["post-8174","wiki","type-wiki","status-publish","format-standard","category-glosario-definiciones","tag-patologia"],"_links":{"self":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/8174","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki"}],"about":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/types\/wiki"}],"author":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/comments?post=8174"}],"version-history":[{"count":0,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/8174\/revisions"}],"wp:attachment":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/media?parent=8174"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/categories?post=8174"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/tags?post=8174"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}