{"id":8218,"date":"2020-04-27T17:32:59","date_gmt":"2020-04-27T20:32:59","guid":{"rendered":"https:\/\/doctorhoogstra.com\/es\/wiki\/gangrena-mojada\/"},"modified":"2020-04-27T17:32:59","modified_gmt":"2020-04-27T20:32:59","slug":"gangrene-wet","status":"publish","type":"wiki","link":"https:\/\/doctorhoogstra.com\/en\/wiki\/gangrena-mojada\/","title":{"rendered":"Wet gangrene"},"content":{"rendered":"<p><\/p><div id=\"ez-toc-container\" class=\"ez-toc-v2_0_89 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 eztoc-toggle-hide-by-default' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/gangrena-mojada\/#Lo-que-esta-mojado-gangrena\" >What is wet gangrene?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/gangrena-mojada\/#%C2%BFQue-causa-las-infecciones-bacterianas-necrotizantes\" >What causes necrotizing bacterial infections?<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/gangrena-mojada\/#1-Necrotizacion-polimicrobiana-infeccion\" >1. Polymicrobial necrotization infection<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/gangrena-mojada\/#Gangrena-gaseosa\" >gas gangrene<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/gangrena-mojada\/#2-Estreptococo-y-estafilococo-del-grupo-A\" >2. Group A Streptococcus and Staphylococcus<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/gangrena-mojada\/#3-Marina-gramnegativa-organismos\" >3. Marine gram-negative organisms<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/gangrena-mojada\/#%C2%BFQuien-contrae-infecciones-bacterianas-necrotizantes\" >Who gets necrotizing bacterial infections?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/gangrena-mojada\/#%C2%BFCuales-son-las-caracteristicas-clinicas-de-las-infecciones-bacterianas-necrotizantes\" >What are the clinical characteristics of necrotizing bacterial infections?<\/a><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/gangrena-mojada\/#Infecciones-necrotizantes-de-la-piel-con-gangrena\" >Necrotizing skin infections with gangrene<\/a><\/li><\/ul><\/li><\/ul><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/gangrena-mojada\/#Investigaciones-en-infecciones-necrotizantes\" >Research in necrotizing infections.<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/gangrena-mojada\/#Pruebas-de-laboratorio\" >Lab tests<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/gangrena-mojada\/#Imagen\" >Image<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/gangrena-mojada\/#Exploracion-quirurgica\" >Surgical exploration<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/gangrena-mojada\/#%C2%BFCual-es-el-tratamiento-para-la-gangrena-humeda-establecida\" >What is the treatment for established wet gangrene?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/doctorhoogstra.com\/en\/wiki\/gangrena-mojada\/#Cual-es-el-pronostico-para-la-gangrena-humeda\" >What is the prognosis for wet gangrene?<\/a><\/li><\/ul><\/nav><\/div>\n\n<section class=\"textBlock\">\n<h2><span class=\"ez-toc-section\" id=\"Lo-que-esta-mojado-gangrena\"><\/span>What is wet <span class=\"term\" data-term-id=\"1286\">gangrene<\/span>?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span>Gangrene<\/span><span> the <span class=\"term\" data-term-id=\"324\">located<\/span> death of body tissue. <\/span>Wet gangrene is gangrene due to <span class=\"term\" data-term-id=\"1411\">necrotizing<\/span> <span class=\"term\" data-term-id=\"937\">bacterial<\/span> infections, including necrotizing fasciitis. Wet gangrene must be distinguished from &#039;dry&#039; gangrene, which is due to <span class=\"term\" data-term-id=\"153\">ischemia<\/span>.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%C2%BFQue-causa-las-infecciones-bacterianas-necrotizantes\"><\/span>What causes necrotizing bacterial infections?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Necrotizing bacterial infections can occur through any break in the skin or internal organ. They are caused by 3 main bacterial subgroups:<\/p>\n<h3><span class=\"ez-toc-section\" id=\"1-Necrotizacion-polimicrobiana-infeccion\"><\/span>1. Polymicrobial necrotization <span class=\"term\" data-term-id=\"145\">infection<\/span><br \/>\n<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Polymicrobial necrotizing infections often involve a mixture of:<\/p>\n<ul>\n<li>gram positive cocci<\/li>\n<li>gram negative rods<\/li>\n<li>anaerobes, including clostridial species.<\/li>\n<\/ul>\n<p>Polymicrobial necrotizing infections tend to affect the trunk and <span class=\"term\" data-term-id=\"889\">perineum<\/span>.<\/p>\n<p>Patients with these infections usually have a history of other medical problems, especially diabetes, and are likely to be elderly. The initial skin injury may have gone unnoticed.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Gangrena-gaseosa\"><\/span>gas gangrene<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Gas gangrene is particularly serious and is most often due to <em>Clostridium perfringens<\/em>, which can proliferate rapidly in injured muscles. This <span class=\"term\" data-term-id=\"882\">organism<\/span> It is ubiquitous in soil and dust. Gas gangrene was very <span class=\"term\" data-term-id=\"1676\">predominant<\/span> in World War I, which complicates 6% of open fractures and 1% of all open wounds. Clostridia releases alpha, beta and others <span class=\"term\" data-term-id=\"1922\">toxins<\/span>, which induce blood clotting at the site of infection and cause myonecrosis (death of muscle tissue). Reduced blood flow, localized ischemia and decreased <span class=\"term\" data-term-id=\"890\">pH<\/span> result in a favorable environment for others <span class=\"term\" data-term-id=\"935\">bacteria<\/span> grow. The gas is composed of nitrogen, oxygen, hydrogen, hydrogen sulfide and carbon dioxide. It spreads within the muscle fibers allowing rapid spread of the infection.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"2-Estreptococo-y-estafilococo-del-grupo-A\"><\/span>2. Group A Streptococcus and Staphylococcus<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Group A \u03b2-hemolytic streptococci (GAS), alone or in association with staphylococcal species, tend to be locally aggressive and can cause serious blood infections such as <span class=\"term\" data-term-id=\"1159\">toxic<\/span> shock <span class=\"term\" data-term-id=\"350\">syndrome<\/span>.<\/p>\n<p>Patients with streptococcal and staphylococcal infections are likely to be younger and have better overall health than those with polymicrobial infections. The entry route generally follows <span class=\"term\" data-term-id=\"1365\">trauma<\/span>, including surgery and intravenous (ab) drug use. The M proteins produced by GAS allow bacteria to adhere to tissue and evade the immune system. The M protein can also be activated <span class=\"term\" data-term-id=\"419\">T <span class=\"term\" data-term-id=\"421\">lymphocytes<\/span><\/span>, which can lead to a <span class=\"term\" data-term-id=\"490\">inflammatory<\/span> Shock response.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"3-Marina-gramnegativa-organismos\"><\/span>3. Gram-negative marine <span class=\"term\" data-term-id=\"883\">organisms<\/span><br \/>\n<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Marine organisms such as <em>Vibrio vulnificus<\/em> They are rare causes of gangrene and have been reported mainly in warm coastal regions. The route of infection may be through an open wound exposed to water, or via <span class=\"term\" data-term-id=\"406\">ingestion<\/span> of infected oysters. <span class=\"term\" data-term-id=\"380\">Systemic<\/span> <span class=\"term\" data-term-id=\"1160\">toxicity<\/span> It tends to happen early.<\/p>\n<div id=\"square-placement-country-holder\" class=\"country-dependent advert\">\n<div class=\"box-placement square-placement\">\n<div class=\"advert__frame\">\n<div id=\"dermnet-dermnet-mobbox\">\n<\/div><\/div><\/div><\/div>\n<h2><span class=\"ez-toc-section\" id=\"%C2%BFQuien-contrae-infecciones-bacterianas-necrotizantes\"><\/span>Who gets necrotizing bacterial infections?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Risk factors for necrotizing infections include:<\/p>\n<ul>\n<li>Mellitus diabetes<\/li>\n<li>\n<span class=\"term\" data-term-id=\"1384\">Atherosclerosis<\/span> and <span class=\"term\" data-term-id=\"1374\">peripheral<\/span> <span class=\"term\" data-term-id=\"753\">vascular<\/span> disease<\/li>\n<li>Trauma<\/li>\n<li>Surgery, especially operations on the colon or gallbladder<\/li>\n<li>\n<p>intravenous drug and <span class=\"term\" data-term-id=\"1510\">insulin<\/span> injection<\/li>\n<li>\n<p>skin infections, <span class=\"term\" data-term-id=\"536\">erosions<\/span> and <span class=\"term\" data-term-id=\"1279\">ulcers<\/span>\n<\/li>\n<li>\n<p>Animal and insect bites.\n<\/li>\n<li>\n<span class=\"term\" data-term-id=\"772\">Visceral<\/span>&#8211;<span class=\"term\" data-term-id=\"47\">cutaneous<\/span> <span class=\"term\" data-term-id=\"508\">fistulas<\/span>\n<\/li>\n<li><span style=\"line-height: 1.4;\">Percutaneous <span class=\"term\" data-term-id=\"1755\">catheter<\/span> insertion<\/span><\/li>\n<li>Abscesses<\/li>\n<li>Urinary tract infection<\/li>\n<li>\n<p>Strep throat (tonsillitis)<\/li>\n<li>\n<p>Alcohol abuse<\/li>\n<li>\n<p>Immune deficiency, including human immunodeficiency virus (<span class=\"term\" data-term-id=\"127\">HIV<\/span>) infection <\/li>\n<li>\n<span class=\"term\" data-term-id=\"1698\">Immunosuppression<\/span> for medications<\/li>\n<li>Anticoagulants, especially the combination of warfarin (coumadin) and heparin.<\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"%C2%BFCuales-son-las-caracteristicas-clinicas-de-las-infecciones-bacterianas-necrotizantes\"><\/span>What are the clinical characteristics of necrotizing bacterial infections?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The clinical features of necrotizing infections depend on the location and cause.<\/p>\n<p>Necrotizing infections often resemble cellulitis or a <span class=\"term\" data-term-id=\"1\">abscess<\/span> initially, but progresses to discoloration (blue to black), smelly <span class=\"term\" data-term-id=\"840\">download<\/span>and\/or numbness. If the affected area is internal, symptoms may include confusion, <span class=\"term\" data-term-id=\"1176\">fever<\/span>, gas in the tissues under the skin, low blood pressure and persistent or severe pain.<\/p>\n<p>The first signs of gangrene that should prompt urgent investigation are:<\/p>\n<ul>\n<li>\n<span class=\"term\" data-term-id=\"499\">Bullas<\/span> (blisters), often <span class=\"term\" data-term-id=\"121\">hemorrhagic<\/span>\n<\/li>\n<li>\n<span class=\"term\" data-term-id=\"1280\">Ecchymosis<\/span> (bruises) previous <span class=\"term\" data-term-id=\"403\">necrosis<\/span> (tissue death)<\/li>\n<li>Crepitation (gas in the tissues)<\/li>\n<li>Cutaneous <span class=\"term\" data-term-id=\"1210\">anesthesia<\/span> (numbness).<\/li>\n<\/ul>\n<p>Less specific signs that should increase clinical suspicion of necrotizing infection include:<\/p>\n<ul>\n<li>Pain disproportionate to signs of illness.<\/li>\n<li>Swelling that extends beyond the reddened skin area.<\/li>\n<li>Systemic toxicity<\/li>\n<li>Progression of infection despite antibiotic treatment.<\/li>\n<\/ul>\n<p>Necrotizing skin infections can rapidly progress to wet gangrene, unlike cellulitis or abscess.<\/p>\n<section class=\"textBlock imageLinkBlockTitle\">\n<h5 class=\"colour--primary\"><span class=\"ez-toc-section\" id=\"Infecciones-necrotizantes-de-la-piel-con-gangrena\"><\/span>Necrotizing skin infections with gangrene<span class=\"ez-toc-section-end\"><\/span><\/h5>\n<\/section>\n<section class=\"imageLinkBlock\">\n<div class=\"flex\">\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='gangrene-3__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-2191447-6860391' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/gangrene-3__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-2191447.jpg'>\n<\/div>\n<p class=\"p-small\">Necrotizing skin infection<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='gangrene-5__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-8813222-1102898' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/gangrene-5__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-8813222.jpg'>\n<\/div>\n<p class=\"p-small\">Necrotizing skin infection<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='gangrene-6__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-9645310-5517397' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/gangrene-6__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-9645310.jpg'>\n<\/div>\n<p class=\"p-small\">Necrotizing skin infection<\/p>\n<\/p><\/div>\n<\/section>\n<div class=\"clearfix imageLinkBlock\"><\/div>\n<h2><span class=\"ez-toc-section\" id=\"Investigaciones-en-infecciones-necrotizantes\"><\/span>Research in necrotizing infections.<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h3><span class=\"ez-toc-section\" id=\"Pruebas-de-laboratorio\"><\/span>Lab tests<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Blood cultures should be performed to identify specific organisms involved in the infection.<\/p>\n<p>The table below was developed as a risk indicator for necrotizing fasciitis by Wong et al. in 2004. Scores \u2265 6 were found to have a positive predictive value of 92% and a negative predictive value of 96%.<\/p>\n<table class=\"borders\">\n<tbody>\n<caption>Elements of the Laboratory Risk Indicator for Necrotizing Fasciitis Score (LRINEC)<\/caption>\n<\/tbody>\n<tbody>\n<tr>\n<th>laboratory marker<\/th>\n<th>Score evaluation<\/th>\n<\/tr>\n<tr>\n<td>\n<span class=\"term\" data-term-id=\"947\">CRP<\/span> (mg\/dL)<\/td>\n<td><150 > &gt; 150 = 4 points<\/td>\n<\/tr>\n<tr>\n<td>WBC (per mm<sup>3<\/sup>)<\/td>\n<td><15 > 15-25 = 1 point<br \/> &gt; 25 = 2 points<\/td>\n<\/tr>\n<tr>\n<td>Hb (g\/dL)<\/td>\n<td>&gt; 13.5 = 0 points<br \/> 11.6\u201313.5 = 1 point<br \/> <11.5 = 2 puntos<\/td>\n<\/tr>\n<tr>\n<td>\n<span class=\"term\" data-term-id=\"1430\">Serum<\/span> sodium<\/td>\n<td>&gt; 135 = 0 points<br \/> <135 >\n<\/tr>\n<tr>\n<td>serum creatinine<\/td>\n<td>\u2264 1.6 = 0 points<br \/> &gt; 1.6 = 2 points<\/td>\n<\/tr>\n<tr>\n<td>Serum <span class=\"term\" data-term-id=\"559\">glucose<\/span>\n<\/td>\n<td><180 > &gt; 180 = 1 point<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>PCR: <span class=\"term\" data-term-id=\"946\">C-reactive protein<\/span>; Half pension: <span class=\"term\" data-term-id=\"1205\">hemoglobin<\/span>.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Imagen\"><\/span>Image<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Imaging has a limited role in the diagnosis of infectious gangrene.<\/p>\n<ul>\n<li>Plain radiography can demonstrate <span class=\"term\" data-term-id=\"900\">subcutaneous<\/span> emphysema (gas under the skin) sometimes present in clostridial infections.<\/li>\n<li>\n<span class=\"term\" data-term-id=\"799\">Connecticut<\/span> scan may show fascial thickening, <span class=\"term\" data-term-id=\"201\">edema<\/span>, subcutaneous gas and abscess formation.<\/li>\n<li>\n<span class=\"term\" data-term-id=\"1116\">Magnetic resonance<\/span> The scan shows similar findings to CT but is less specific as tissue enhancement can mimic other inflammatory processes.<\/li>\n<\/ul>\n<h3><span class=\"ez-toc-section\" id=\"Exploracion-quirurgica\"><\/span>Surgical exploration<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<ul>\n<li>Surgery is the gold standard for diagnosing necrotizing fasciitis: <span class=\"term\" data-term-id=\"1761\">fascia<\/span> It separates from the surrounding tissue.<\/li>\n<li>Little <span class=\"term\" data-term-id=\"807\">incisions<\/span> with local exploration are useful to identify <span class=\"term\" data-term-id=\"770\">necrotic<\/span> tissue in other cases.<\/li>\n<\/ul>\n<div id=\"square-placement-country-holder\" class=\"country-dependent advert\">\n<div class=\"box-placement square-placement\">\n<div class=\"advert__frame\">\n<div id=\"dermnet-dermnet-mobbox\">\n<\/div><\/div><\/div><\/div>\n<h2><span class=\"ez-toc-section\" id=\"%C2%BFCual-es-el-tratamiento-para-la-gangrena-humeda-establecida\"><\/span>What is the treatment for established wet gangrene?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Treatment for gangrene depends on the location and cause, but focuses on:<\/p>\n<ul>\n<li>radical surgical <span class=\"term\" data-term-id=\"606\">debridement<\/span> +\/- amputation<\/li>\n<li>Spread spectrum <span class=\"term\" data-term-id=\"516\">antimicrobial<\/span> Therapy: Penicillin G, clindamycin, vancomycin, and gentamicin can be used for empiric therapy for methicillin-resistant Staphylococcus aureus (MRSA), gram-negative, gram-positive, and <span class=\"term\" data-term-id=\"1181\">anaerobic<\/span> organisms<\/li>\n<li>Hemodynamic support.<\/li>\n<\/ul>\n<p>Administration may also include:<\/p>\n<ul>\n<li>\n<p>Worm debridement therapy: Worms consume dead and infected tissue<\/li>\n<li>Vascular surgery to improve circulation.<\/li>\n<li>Hyperbaric oxygen, especially in patients with diabetes or peripheral vascular disease.<\/li>\n<li>\n<p>Intravenous <span class=\"term\" data-term-id=\"427\">immunoglobulin<\/span> \u2013 This can limit the inflammatory response by binding staphylococcal and streptococcal toxins.<\/li>\n<li>Treatment of underlying conditions such as diabetes.<\/li>\n<\/ul>\n<p>the <span class=\"term\" data-term-id=\"578\">incidence<\/span> of wartime gas gangrene has been markedly reduced with case identification and isolation, and early debridement, amputation, and supportive treatment.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Cual-es-el-pronostico-para-la-gangrena-humeda\"><\/span>Which is the <span class=\"term\" data-term-id=\"241\">forecast<\/span> for wet gangrene?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The prognosis in wet gangrene depends on the extent of the disease, the underlying cause, and the timing of appropriate treatment.<\/p>\n<p>Anaya et.al have constructed a clinical score to predict patient outcomes for infectious gangrene based on several clinical criteria:<\/p>\n<ul>\n<li>Heart rate &gt; 110 beats per minute<\/li>\n<li>Temperature <36 grados cent\u00edgrados<\/li>\n<li>Serum creatinine &gt; 1.5 mg\/dL<\/li>\n<li>Age &gt; 50 years<\/li>\n<li>WBC &gt; 40,000 per uL<\/li>\n<li>\n<span class=\"term\" data-term-id=\"1294\">Hematocrit<\/span> > 50%<\/li>\n<\/ul>\n<p>Patients with few of these findings had a risk of death of 6% in this study, while patients with several findings had a risk of death of up to 88%. The prognosis can vary widely due to the aggressive nature of gangrene if early treatment is not accessed.<\/p>\n<\/section>","protected":false},"excerpt":{"rendered":"<p>Lo que esta mojado gangrena? Gangrena la localizado muerte del tejido corporal. La gangrena h\u00fameda es gangrena debido a necrotizante bacteriano infecciones, incluida la fascitis necrotizante. La gangrena h\u00fameda debe&#8230;<\/p>","protected":false},"author":8,"featured_media":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-8218","wiki","type-wiki","status-publish","format-standard"],"_links":{"self":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/8218","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki"}],"about":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/types\/wiki"}],"author":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/comments?post=8218"}],"version-history":[{"count":0,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/wiki\/8218\/revisions"}],"wp:attachment":[{"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/media?parent=8218"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/categories?post=8218"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/en\/wp-json\/wp\/v2\/tags?post=8218"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}