{"id":16543,"date":"2020-04-28T17:49:23","date_gmt":"2020-04-28T20:49:23","guid":{"rendered":"https:\/\/doctorhoogstra.com\/es\/wiki\/patologia-del-sarcoma-de-kaposi\/"},"modified":"2020-04-30T21:27:23","modified_gmt":"2020-05-01T00:27:23","slug":"pathologie-du-sarcome-de-kaposi","status":"publish","type":"wiki","link":"https:\/\/doctorhoogstra.com\/fr\/wiki\/patologia-del-sarcoma-de-kaposi\/","title":{"rendered":"Pathologie du sarcome de Kaposi"},"content":{"rendered":"<p><\/p><div id=\"ez-toc-container\" class=\"ez-toc-v2_0_88 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Contenu<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Basculer la table des mati\u00e8res\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Basculer<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 eztoc-toggle-hide-by-default' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/doctorhoogstra.com\/fr\/wiki\/patologia-del-sarcoma-de-kaposi\/#Introduccion\" >introduction<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/doctorhoogstra.com\/fr\/wiki\/patologia-del-sarcoma-de-kaposi\/#Histologia-del-sarcoma-de-Kaposi\" >Histologie du sarcome de Kaposi<\/a><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/doctorhoogstra.com\/fr\/wiki\/patologia-del-sarcoma-de-kaposi\/#Patologia-del-sarcoma-de-Kaposi\" >Pathologie du sarcome de Kaposi<\/a><\/li><\/ul><\/li><\/ul><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/doctorhoogstra.com\/fr\/wiki\/patologia-del-sarcoma-de-kaposi\/#Histologico-variantes-del-sarcoma-de-Kaposi\" >Variantes histologiques du sarcome de Kaposi<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/doctorhoogstra.com\/fr\/wiki\/patologia-del-sarcoma-de-kaposi\/#Pruebas-especiales-en-el-sarcoma-de-Kaposi\" >Tests sp\u00e9ciaux dans le sarcome de Kaposi.<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/doctorhoogstra.com\/fr\/wiki\/patologia-del-sarcoma-de-kaposi\/#Diagnostico-diferencial-del-sarcoma-de-Kaposi\" >Diagnostic diff\u00e9rentiel du sarcome de Kaposi<\/a><\/li><\/ul><\/nav><\/div>\n\n<section class=\"textBlock\">\n<h2><span class=\"ez-toc-section\" id=\"Introduccion\"><\/span>introduction<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Kaposi <span class=\"term\" data-term-id=\"1665\">sarcome<\/span> c&#039;est <span class=\"term\" data-term-id=\"116\">group\u00e9<\/span> Dans <span class=\"term\" data-term-id=\"753\">vasculaire<\/span> tumeurs variables <span class=\"term\" data-term-id=\"176\">le mal<\/span> comportement. Les <span class=\"term\" data-term-id=\"128\">histologie<\/span> Il est g\u00e9n\u00e9ralement tr\u00e8s distinctif. Les caract\u00e9ristiques changent en fonction de la nature du <span class=\"term\" data-term-id=\"164\">blessure<\/span> cliniquement que vous progressez de la <span class=\"term\" data-term-id=\"224\">pi\u00e8ce<\/span> \u00e0 <span class=\"term\" data-term-id=\"235\">plaque d&#039;immatriculation<\/span> \u00e0 <span class=\"term\" data-term-id=\"733\">nodulaire<\/span> phase.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Histologia-del-sarcoma-de-Kaposi\"><\/span>Histologie du sarcome de Kaposi<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>La vue \u00e0 faible puissance de l&#039;histologie du sarcome de Kaposi est l&#039;une des <span class=\"term\" data-term-id=\"956\">cellulaire<\/span> <span class=\"term\" data-term-id=\"52\">dermique<\/span> <span class=\"term\" data-term-id=\"198\">nodule<\/span> (Figure 1). Il peut y avoir diff\u00e9rents degr\u00e9s de chevauchement <span class=\"term\" data-term-id=\"846\">\u00e9pidermique<\/span> des changements pouvant aller de pro\u00e9minents <span class=\"term\" data-term-id=\"610\">hyperk\u00e9ratose<\/span> et <span class=\"term\" data-term-id=\"2\">acanthose<\/span> Franc <span class=\"term\" data-term-id=\"1278\">ulc\u00e9ration<\/span>. Le derme <span class=\"term\" data-term-id=\"893\">prolif\u00e9ration<\/span> est compos\u00e9 d&#039;un <span class=\"term\" data-term-id=\"1659\">cellule de broche<\/span> prolif\u00e9ration de <span class=\"term\" data-term-id=\"758\">endoth\u00e9liale<\/span> cellules qui forment des espaces vasculaires sinueux. Ceux-ci peuvent \u00eatre rares dans les blessures en phase patch, \u00e9voluant vers <span class=\"term\" data-term-id=\"1674\">fascicules<\/span> de <span class=\"term\" data-term-id=\"1660\">cellules fusiformes<\/span> dans les l\u00e9sions nodulaires (figures 2,3). Ce motif fasciculaire a \u00e9t\u00e9 compar\u00e9 \u00e0 des bancs de poissons. Cellules de fuseau <span class=\"term\" data-term-id=\"541\">infiltrer<\/span> \u00e0 travers de <span class=\"term\" data-term-id=\"39\">collag\u00e8ne<\/span>, formant des espaces en forme de fente, notamment vers la p\u00e9riph\u00e9rie des l\u00e9sions (figure 4). Lorsque les navires nouvellement form\u00e9s se projettent dans un espace existant, le promontoire <span class=\"term\" data-term-id=\"899\">signer<\/span> vu (figure 5). Ceci est maintenant reconnu comme non sp\u00e9cifique \u00e0 cette condition.<\/p>\n<p>Sur la plaque et les l\u00e9sions du stade nodulaire, il peut \u00eatre visible <span class=\"term\" data-term-id=\"1684\">intracellulaire<\/span> et extracellulaire <span class=\"term\" data-term-id=\"1602\">hyalin<\/span> globules, bien que pour repr\u00e9senter englouti <span class=\"term\" data-term-id=\"696\">\u00e9rythrocytes<\/span>. Bien que rare, cela peut \u00eatre constat\u00e9 dans les blessures au stade du patch. Ils tachent le PAS positif. Alors que la prolif\u00e9ration endoth\u00e9liale est fr\u00e9quente <span class=\"term\" data-term-id=\"325\">monomorphe<\/span>peut \u00eatre important <span class=\"term\" data-term-id=\"1612\">nucl\u00e9aire<\/span> <span class=\"term\" data-term-id=\"1305\">atypie<\/span> avec plus <span class=\"term\" data-term-id=\"1536\">mitotique<\/span> activit\u00e9 (figure 6). Quand une atypie pro\u00e9minente est observ\u00e9e <span class=\"term\" data-term-id=\"289\">tumeur<\/span> s&#039;inscrit dans la cat\u00e9gorie d&#039;un <span class=\"term\" data-term-id=\"1327\">anaplasique<\/span> une variante.<\/p>\n<p>Les <span class=\"term\" data-term-id=\"490\">inflammatoire<\/span> l&#039;infiltrateur est principalement <span class=\"term\" data-term-id=\"422\">lymphocytaire<\/span> avec dispers\u00e9 <span class=\"term\" data-term-id=\"1513\">plasma<\/span> Les cellules sont \u00e9galement un indice de ce diagnostic. Les \u00e9rythrocytes sont visibles dans les espaces d&#039;indentation et dans toute la tumeur. Parfois, \u00e0 la base et \u00e0 la p\u00e9riph\u00e9rie du Kaposi nodulaire, il peut y avoir de gros vaisseaux caverneux.<\/p>\n<section class=\"textBlock imageLinkBlockTitle\">\n<h5 class=\"colour--primary\"><span class=\"ez-toc-section\" id=\"Patologia-del-sarcoma-de-Kaposi\"><\/span>Pathologie du sarcome de Kaposi<span class=\"ez-toc-section-end\"><\/span><\/h5>\n<\/section>\n<section class=\"imageLinkBlock\">\n<div class=\"flex\">\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='kaposisfigure1__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisinkildbd-7250901-9416101' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/KaposisFigure1__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsInkiLDBd-7250901.jpg'>\n<\/div>\n<p class=\"p-small\">Figure 1<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='kaposisfigure2__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-5734811-9409644' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/KaposisFigure2__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-5734811.jpg'>\n<\/div>\n<p class=\"p-small\">Figure 2<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='kaposisfigure3__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-6189025-5118940' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/KaposisFigure3__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-6189025.jpg'>\n<\/div>\n<p class=\"p-small\">figure 3<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='kaposisfigure5__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-8589958-3226545' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/KaposisFigure5__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-8589958.jpg'>\n<\/div>\n<p class=\"p-small\">Figure 4<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='kaposisfigure6__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-5660565-9674462' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/KaposisFigure6__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-5660565.jpg'>\n<\/div>\n<p class=\"p-small\">Figure 5<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='kaposisfigure7__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-9905460-5424057' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/KaposisFigure7__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-9905460.jpg'>\n<\/div>\n<p class=\"p-small\">Figure 6<\/p>\n<\/p><\/div>\n<\/section>\n<div class=\"clearfix imageLinkBlock\"><\/div>\n<div id=\"square-placement-country-holder\" class=\"country-dependent advert\">\n<div class=\"box-placement square-placement\">\n<div class=\"advert__frame\">\n<div id=\"dermnet-dermnet-mobbox\">\n<\/div><\/div><\/div><\/div>\n<h2><span class=\"ez-toc-section\" id=\"Histologico-variantes-del-sarcoma-de-Kaposi\"><\/span>\n<span class=\"term\" data-term-id=\"474\">Histologique<\/span> Variantes du sarcome de Kaposi<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>De nombreuses variations pathologiques ont \u00e9t\u00e9 d\u00e9crites pour le sarcome de Kaposi en fonction de la nature des caract\u00e9ristiques suppl\u00e9mentaires associ\u00e9es ou du sch\u00e9ma de prolif\u00e9ration cutan\u00e9e. Ils sont largement intuitifs pour d\u00e9crire la blessure. Les variantes signal\u00e9es comprennent:<\/p>\n<ul>\n<li>Anaplasique<\/li>\n<li>T\u00e9langiectatique<\/li>\n<li>Lymphoed\u00e9mateux<\/li>\n<li><span class=\"term\" data-term-id=\"1470\">Hyperk\u00e9ratosique<\/span><\/li>\n<li>Keloidal<\/li>\n<li>Micronodulaire<\/li>\n<li>\n<span class=\"term\" data-term-id=\"254\">Pyogenic<\/span> <span class=\"term\" data-term-id=\"113\">granulome<\/span>-J&#039;aime<\/li>\n<li>Ecchimotique<\/li>\n<li><span class=\"term\" data-term-id=\"1162\">Intravasculaire<\/span><\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"Pruebas-especiales-en-el-sarcoma-de-Kaposi\"><\/span>Tests sp\u00e9ciaux dans le sarcome de Kaposi.<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Les cellules l\u00e9sionnelles du sarcome de Kaposi sont positives pour les marqueurs endoth\u00e9liaux non sp\u00e9cifiques CD31 (figure 7) et CD34, ainsi que pour <span class=\"term\" data-term-id=\"744\">lymphatique<\/span> Marqueur endoth\u00e9lial D2-40 ou podoplanine. Les <span class=\"term\" data-term-id=\"425\">anticorps<\/span> au HHV-8 (virus de l&#039;herp\u00e8s humain 8) <span class=\"term\" data-term-id=\"1040\">latent<\/span> nucl\u00e9aire <span class=\"term\" data-term-id=\"410\">antig\u00e8ne<\/span> 1 est une tache commerciale tr\u00e8s sp\u00e9cifique et a un diagnostic simplifi\u00e9 dans les cas difficiles. Figure 8.<\/p>\n<section class=\"imageLinkBlock\">\n<div class=\"flex\">\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='kaposisfigure8cd31__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-3104040-1436221' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/KaposisFigure8CD31__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-3104040.jpg'>\n<\/div>\n<p class=\"p-small\">Figure 7<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='kaposisfigure9hhv8__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-9697596-6550583' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/KaposisFigure9HHV8__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-9697596.jpg'>\n<\/div>\n<p class=\"p-small\">Figure 8<\/p>\n<\/p><\/div>\n<\/section>\n<div class=\"clearfix imageLinkBlock\"><\/div>\n<h2><span class=\"ez-toc-section\" id=\"Diagnostico-diferencial-del-sarcoma-de-Kaposi\"><\/span>\n<span class=\"term\" data-term-id=\"813\">Diagnostic diff\u00e9rentiel<\/span> le sarcome de Kaposi<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Microvenular <span class=\"term\" data-term-id=\"360\">h\u00e9mangiome<\/span>: Cette tumeur vasculaire peut \u00eatre difficile \u00e0 distinguer cliniquement des l\u00e9sions de patch \u00e0 un stade pr\u00e9coce. Navires moins bien form\u00e9s, pr\u00e9sence d&#039;\u00e9nergie nucl\u00e9aire. <span class=\"term\" data-term-id=\"1539\">pl\u00e9omorphisme<\/span> et positif <span class=\"term\" data-term-id=\"1421\">immunohistochimie<\/span> Le HHV-8 est compatible avec le sarcome de Kaposi.<\/p>\n<p>H\u00e9mangiome touffu: plusieurs lobes de cellules fusiformes sont observ\u00e9s, mais ils ne pr\u00e9sentent pas le sch\u00e9ma de verrouillage du sarcome de Kaposi ou la formation d&#039;un canal vasculaire en forme de fente.<\/p>\n<p>Sarcome pseudo-kaposi (acroangiodermatite): alors qu&#039;au stade pr\u00e9coce du sarcome de Kaposi, l&#039;acroangiodermatite est form\u00e9e par une prolif\u00e9ration r\u00e9guli\u00e8re de petits vaisseaux sans l&#039;apparence sinueuse du sarcome de Kaposi.<\/p>\n<p>H\u00e9mangiome caverneux: cela peut \u00eatre envisag\u00e9 lorsqu&#039;il y a des vaisseaux dilat\u00e9s \u00e0 la base ou \u00e0 la p\u00e9riph\u00e9rie des l\u00e9sions au stade nodulaire, mais cet h\u00e9mangiome manque d&#039;une composante de la cellule fusiforme.<\/p>\n<p>Granulome pyog\u00e9nique: Habituellement, seulement un probl\u00e8me dans les l\u00e9sions de biopsie partielle dans lesquelles seule la composante superficielle de la l\u00e9sion est d\u00e9montr\u00e9e.<\/p>\n<\/section>","protected":false},"excerpt":{"rendered":"<p>Introducci\u00f3n Kaposi sarcoma es agrupado dentro vascular tumores de variable maligno comportamiento. los histolog\u00eda Es t\u00edpicamente muy distintivo. Las caracter\u00edsticas cambian dependiendo de la naturaleza del lesi\u00f3n cl\u00ednicamente a medida&#8230;<\/p>","protected":false},"author":8,"featured_media":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","format":"standard","meta":{"footnotes":""},"categories":[204],"tags":[205],"class_list":["post-16543","wiki","type-wiki","status-publish","format-standard","category-glosario-definiciones","tag-patologia"],"_links":{"self":[{"href":"https:\/\/doctorhoogstra.com\/fr\/wp-json\/wp\/v2\/wiki\/16543","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/doctorhoogstra.com\/fr\/wp-json\/wp\/v2\/wiki"}],"about":[{"href":"https:\/\/doctorhoogstra.com\/fr\/wp-json\/wp\/v2\/types\/wiki"}],"author":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/fr\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/fr\/wp-json\/wp\/v2\/comments?post=16543"}],"version-history":[{"count":0,"href":"https:\/\/doctorhoogstra.com\/fr\/wp-json\/wp\/v2\/wiki\/16543\/revisions"}],"wp:attachment":[{"href":"https:\/\/doctorhoogstra.com\/fr\/wp-json\/wp\/v2\/media?parent=16543"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/fr\/wp-json\/wp\/v2\/categories?post=16543"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/fr\/wp-json\/wp\/v2\/tags?post=16543"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}