{"id":7001,"date":"2020-04-24T02:17:00","date_gmt":"2020-04-24T05:17:00","guid":{"rendered":"https:\/\/doctorhoogstra.com\/es\/efectos-adversos-cutaneos-de-los-anticonvulsivos-2\/"},"modified":"2020-04-27T16:34:09","modified_gmt":"2020-04-27T19:34:09","slug":"effets-cutanes-indesirables-des-anticonvulsivants-2","status":"publish","type":"wiki","link":"https:\/\/doctorhoogstra.com\/fr\/wiki\/efectos-adversos-cutaneos-de-los-anticonvulsivos-2\/","title":{"rendered":"Effets ind\u00e9sirables cutan\u00e9s des anticonvulsivants"},"content":{"rendered":"<p><\/p><div id=\"ez-toc-container\" class=\"ez-toc-v2_0_88 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Contenu<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Basculer la table des mati\u00e8res\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Basculer<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 eztoc-toggle-hide-by-default' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/doctorhoogstra.com\/fr\/wiki\/efectos-adversos-cutaneos-de-los-anticonvulsivos-2\/#Introduccion\" >introduction<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/doctorhoogstra.com\/fr\/wiki\/efectos-adversos-cutaneos-de-los-anticonvulsivos-2\/#Drogas-anticonvulsivas\" >M\u00e9dicaments anticonvulsivants<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/doctorhoogstra.com\/fr\/wiki\/efectos-adversos-cutaneos-de-los-anticonvulsivos-2\/#Reacciones-cutaneas-adversas\" >R\u00e9actions cutan\u00e9es ind\u00e9sirables<\/a><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/doctorhoogstra.com\/fr\/wiki\/efectos-adversos-cutaneos-de-los-anticonvulsivos-2\/#Reaccion-adversa-cutanea-a-anticonvulsivos\" >R\u00e9action cutan\u00e9e ind\u00e9sirable aux anticonvulsivants<\/a><\/li><\/ul><\/li><\/ul><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/doctorhoogstra.com\/fr\/wiki\/efectos-adversos-cutaneos-de-los-anticonvulsivos-2\/#Genetico-predisposicion-a-Reacciones-adversas-a-los-anticonvulsivos\" >Pr\u00e9disposition g\u00e9n\u00e9tique aux effets ind\u00e9sirables des anticonvulsivants<\/a><\/li><\/ul><\/nav><\/div>\n\n<section class=\"textBlock\">\n<h2><span class=\"ez-toc-section\" id=\"Introduccion\"><\/span>introduction<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>De nombreux m\u00e9dicaments peuvent provoquer <span class=\"term\" data-term-id=\"47\">cutan\u00e9<\/span> effets secondaires (cutan\u00e9s). La gravit\u00e9 des sympt\u00f4mes peut varier de l\u00e9g\u00e8re <span class=\"term\" data-term-id=\"255\">\u00e9ruption<\/span> \u00e0 des conditions potentiellement mortelles qui provoquent une insuffisance cutan\u00e9e et la mort. Certains groupes de m\u00e9dicaments sont connus pour provoquer des r\u00e9actions cutan\u00e9es fr\u00e9quentes, sp\u00e9cifiques ou graves. Les anticonvulsivants ou anti\u00e9pileptiques font partie de ces groupes de m\u00e9dicaments, dont certains ont des effets secondaires notables sur la peau.<\/p>\n<p>Il est important de reconna\u00eetre les effets secondaires impliquant la peau, car le retrait rapide du m\u00e9dicament peut emp\u00eacher l&#039;aggravation des sympt\u00f4mes caus\u00e9s par le m\u00e9dicament. Il peut \u00eatre n\u00e9cessaire de prendre une d\u00e9cision chez un patient qui a re\u00e7u un m\u00e9dicament <span class=\"term\" data-term-id=\"704\">\u00e9ruption<\/span> s&#039;il faut continuer un m\u00e9dicament important qui aurait pu provoquer la r\u00e9action ou passer \u00e0 un autre m\u00e9dicament.<\/p>\n<p>Face \u00e0 une nouvelle \u00e9ruption cutan\u00e9e chez un patient, un historique complet du m\u00e9dicament est primordial et devrait inclure la prescription, <span class=\"term\" data-term-id=\"1202\">sur le comptoir<\/span>et les m\u00e9dicaments alternatifs que le patient prend afin que le m\u00e9dicament <span class=\"term\" data-term-id=\"1015\">des \u00e9ruptions cutan\u00e9es<\/span> peut \u00eatre consid\u00e9r\u00e9 ou jet\u00e9.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Drogas-anticonvulsivas\"><\/span>M\u00e9dicaments anticonvulsivants<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Les m\u00e9dicaments contre les crises, \u00e9galement connus sous le nom de m\u00e9dicaments anti\u00e9pileptiques ou anticonvulsivants, sont un groupe diversifi\u00e9 de m\u00e9dicaments qui sont couramment utilis\u00e9s dans le traitement de l&#039;\u00e9pilepsie et des convulsions, et moins fr\u00e9quemment pour d&#039;autres conditions telles que le trijumeau. <span class=\"term\" data-term-id=\"347\">n\u00e9vralgie<\/span> et trouble bipolaire. Ils fonctionnent en r\u00e9duisant le d\u00e9clenchement excessif de <span class=\"term\" data-term-id=\"484\">les neurones<\/span> cela se produit lors d&#039;une crise.<\/p>\n<div id=\"square-placement-country-holder\" class=\"country-dependent advert\">\n<div class=\"box-placement square-placement\">\n<div class=\"advert__frame\">\n<div id=\"dermnet-dermnet-mobbox\">\n<\/div><\/div><\/div><\/div>\n<h2><span class=\"ez-toc-section\" id=\"Reacciones-cutaneas-adversas\"><\/span>R\u00e9actions cutan\u00e9es ind\u00e9sirables<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<table>\n<tbody>\n<caption>Types de r\u00e9actions cutan\u00e9es aux anticonvulsivants<\/caption>\n<\/tbody>\n<tbody>\n<tr>\n<th>R\u00e9action<\/th>\n<th>Sympt\u00f4mes<\/th>\n<\/tr>\n<tr>\n<td><span class=\"term\" data-term-id=\"377\">Morbide<\/span> (semblable \u00e0 la rougeole) \u00e9ruption m\u00e9dicamenteuse<\/td>\n<td>\n<ul>\n<li>\n<span class=\"term\" data-term-id=\"309\">\u00c9largi<\/span> ou <span class=\"term\" data-term-id=\"308\">g\u00e9n\u00e9ralis\u00e9<\/span> rose \u00e0 rouge <span class=\"term\" data-term-id=\"938\">maculopapulaire<\/span> \u00e9ruption<\/li>\n<li>D\u00e9mangeaisons<\/li>\n<li>Peut \u00e9voluer vers une exfoliation <span class=\"term\" data-term-id=\"53\">dermatite<\/span>\/ \/<span class=\"term\" data-term-id=\"91\">\u00e9rythrodermie<\/span>\n<\/li>\n<li>R\u00e9sout g\u00e9n\u00e9ralement rapidement lors du retrait du m\u00e9dicament<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td>\n<p>Induite par la drogue <span class=\"term\" data-term-id=\"1646\">urticaire<\/span> (urticaire)<\/td>\n<td>\n<ul>\n<li>Transitoire <span class=\"term\" data-term-id=\"1933\">gu\u00e9rir<\/span> avec des centres p\u00e2les et des bords rouges<\/li>\n<li>Mod\u00e8le migratoire, qui change de forme et d&#039;emplacement pendant plusieurs heures.<\/li>\n<li>\n<span class=\"term\" data-term-id=\"440\">Anaphylaxie<\/span> peut-\u00eatre <span class=\"term\" data-term-id=\"545\">concurrent<\/span> ou cela peut se produire avec l&#039;administration ult\u00e9rieure du m\u00e9dicament<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td><span class=\"term\" data-term-id=\"90\">\u00c9ryth\u00e8me<\/span> multiforme<\/td>\n<td>\n<ul>\n<li>L\u00e9sions blanches (iris)<\/li>\n<li>Peut impliquer <span class=\"term\" data-term-id=\"188\">muqueux<\/span> membranes<\/li>\n<li>Auto-limitant et r\u00e9sout g\u00e9n\u00e9ralement sans complications<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td>Stevens-Johnson <span class=\"term\" data-term-id=\"350\">syndrome<\/span> \/ \/ <span class=\"term\" data-term-id=\"1159\">toxique<\/span> <span class=\"term\" data-term-id=\"846\">\u00e9pidermique<\/span> n\u00e9crolyse (RTE)<\/td>\n<td>\n<ul>\n<li>Il se d\u00e9veloppe g\u00e9n\u00e9ralement au cours de la premi\u00e8re semaine de la prise du m\u00e9dicament.<\/li>\n<li>R\u00e9action cutan\u00e9e grave et potentiellement mortelle avec une peau lamin\u00e9e et <span class=\"term\" data-term-id=\"1018\">membrane muqueuse<\/span> perdu<\/li>\n<li>Rare m\u00e9di\u00e9e par des complexes immuns <span class=\"term\" data-term-id=\"943\">hypersensibilit\u00e9<\/span>\n<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td>Syndrome d&#039;hypersensibilit\u00e9 anticonvulsivante\n<\/td>\n<td>\n<ul>\n<li>Les sympt\u00f4mes se d\u00e9veloppent g\u00e9n\u00e9ralement de 2 \u00e0 6 semaines apr\u00e8s le d\u00e9but du traitement, mais peuvent survenir \u00e0 tout moment.<\/li>\n<li>Les sympt\u00f4mes incluent la triade de <span class=\"term\" data-term-id=\"1176\">fi\u00e8vre<\/span>, \u00e9ruption maculopapuleuse g\u00e9n\u00e9ralis\u00e9e, et <span class=\"term\" data-term-id=\"503\">lymphad\u00e9nopathie<\/span>\n<\/li>\n<li>L&#039;\u00e9ruption s&#039;\u00e9tend \u00e0 des degr\u00e9s divers sur le tronc et les extr\u00e9mit\u00e9s.<\/li>\n<li>Il peut affecter les organes internes tels que les reins, le foie, le syst\u00e8me nerveux central et la moelle osseuse.<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<section class=\"textBlock imageLinkBlockTitle\">\n<h5 class=\"colour--primary\"><span class=\"ez-toc-section\" id=\"Reaccion-adversa-cutanea-a-anticonvulsivos\"><\/span>R\u00e9action cutan\u00e9e ind\u00e9sirable aux anticonvulsivants<span class=\"ez-toc-section-end\"><\/span><\/h5>\n<\/section>\n<section class=\"imageLinkBlock\">\n<div class=\"flex\">\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='ac-morbilliform__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-1749727-8493245' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/ac-morbilliform__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-1749727.jpg'>\n<\/div>\n<p class=\"p-small\">\u00c9ruption cutan\u00e9e morbilliforme<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='ac-urticaria__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-9641689-7953404' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/ac-urticaria__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-9641689.jpg'>\n<\/div>\n<p class=\"p-small\">Urticaire<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='ac-em__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildnd-8258791-5221063' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/ac-em__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDNd-8258791.jpg'>\n<\/div>\n<p class=\"p-small\">\u00c9ryth\u00e8me polymorphe<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='ac-ten__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-1795811-8869399' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/ac-ten__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-1795811.jpg'>\n<\/div>\n<p class=\"p-small\">N\u00e9crolyse \u00e9pidermique toxique<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='ac-purpura__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisinkildg1xq-9054329-9575049' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/ac-purpura__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsInkiLDg1XQ-9054329.jpg'>\n<\/div>\n<p class=\"p-small\">\u00c9ruption cutan\u00e9e purpurique<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='ac-gingiva__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-4536532-8676875' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/ac-gingiva__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-4536532.jpg'>\n<\/div>\n<p class=\"p-small\">Hyperplasie gingivale<\/p>\n<\/p><\/div>\n<\/section>\n<div class=\"clearfix imageLinkBlock\"><\/div>\n<table>\n<tbody>\n<caption>R\u00e9actions sp\u00e9cifiques aux m\u00e9dicaments anticonvulsivants.<\/caption>\n<\/tbody>\n<tbody>\n<tr>\n<th>M\u00e9dicament<\/th>\n<th>R\u00e9action cutan\u00e9e<\/th>\n<th>Remarques<\/th>\n<\/tr>\n<tr>\n<td>Carbamaz\u00e9pine<\/td>\n<td>\n<ul>\n<li>Oral <span class=\"term\" data-term-id=\"1279\">ulc\u00e8res<\/span>\n<\/li>\n<li>Urticaire<\/li>\n<li>Stevens-Johnson \/ TEN<\/li>\n<li><span class=\"term\" data-term-id=\"706\">Photosensibilit\u00e9<\/span><\/li>\n<\/ul>\n<\/td>\n<td>\n<ul>\n<li>Les effets secondaires cutan\u00e9s sont les effets secondaires les plus courants qui provoquent l&#039;arr\u00eat de la carbamaz\u00e9pine.<\/li>\n<li>Il existe une r\u00e9action crois\u00e9e entre la carbamaz\u00e9pine et l&#039;amitriptyline.<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td>Ph\u00e9nyto\u00efne<\/td>\n<td>\n<ul>\n<li>\n<p>\u00c9rythrodermie (rougeur de toute la peau).<\/li>\n<li>Facial <span class=\"term\" data-term-id=\"1016\">pustules<\/span> (acn\u00e9 m\u00e9dicamenteuse)<\/li>\n<li>\n<span class=\"term\" data-term-id=\"135\">Hyperpigmentation<\/span> (assombrissement de la peau)<\/li>\n<li>\n<span class=\"term\" data-term-id=\"1809\">Hypertrichose<\/span> (exc\u00e8s <span class=\"term\" data-term-id=\"122\">cheveux<\/span> augmenter)<\/li>\n<li>Sympt\u00f4mes de type lupus<\/li>\n<li>Syndrome d&#039;hypersensibilit\u00e9 anticonvulsivante\n<\/li>\n<\/ul>\n<\/td>\n<td>\n<ul>\n<li>5-10% des patients utilisant de la ph\u00e9nyto\u00efne ont une r\u00e9action cutan\u00e9e<\/li>\n<li>L&#039;hypertrichose peut \u00eatre irr\u00e9versible<\/li>\n<li>La cause la plus fr\u00e9quente de syndrome d&#039;hypersensibilit\u00e9 anticonvulsivante<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td>Phosph\u00e9nyto\u00efne<\/td>\n<td>\n<ul>\n<li><span class=\"term\" data-term-id=\"498\">Bullous<\/span> \u00e9ruption cutan\u00e9e (cloques)<\/li>\n<li>Dermatite exfoliatrice \/ \u00e9rythrodermie\n<\/li>\n<li><span class=\"term\" data-term-id=\"245\">Prurit<\/span> (d\u00e9manger)<\/li>\n<li>\n<span class=\"term\" data-term-id=\"344\">Gingival<\/span> <span class=\"term\" data-term-id=\"136\">hyperplasie<\/span> (croissance excessive des gencives)<\/li>\n<li>Sympt\u00f4mes de type lupus<\/li>\n<li>\u00c9ryth\u00e8me polymorphe<\/li>\n<\/ul>\n<\/td>\n<td>\n<ul>\n<li>\n<p>Le prurit est pr\u00e9sent dans le 49% des patients et est li\u00e9 \u00e0 la dose.<\/li>\n<li>L&#039;aine est la plus touch\u00e9e<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td>Ph\u00e9nobarbital<\/td>\n<td>\n<ul>\n<li>\u00c9ruption cutan\u00e9e morbilliforme<\/li>\n<li>Urticaire<\/li>\n<li>\u00c9ryth\u00e8me polymorphe<\/li>\n<li>Photosensibilit\u00e9<\/li>\n<li>\u00c9ruption cutan\u00e9e (semblable \u00e0 l&#039;acn\u00e9)<\/li>\n<li><span class=\"term\" data-term-id=\"250\">Violet<\/span><\/li>\n<\/ul>\n<\/td>\n<td> <\/td>\n<\/tr>\n<tr>\n<td>Lamotrigine<\/td>\n<td>\n<ul>\n<li>\n<p>\u00c9ruption cutan\u00e9e morbilliforme (\u00e0 10%)<\/li>\n<li><span class=\"term\" data-term-id=\"1645\">Angioed\u00e8me<\/span><\/li>\n<li>D\u00e9mangeaisons (d\u00e9mangeaisons)<\/li>\n<li>Stevens-Johnson \/ TEN<\/li>\n<li>Syndrome d&#039;hypersensibilit\u00e9 anticonvulsivante\n<\/li>\n<\/ul>\n<\/td>\n<td>\n<ul>\n<li>Des r\u00e9actions cutan\u00e9es mena\u00e7ant le pronostic vital surviennent chez 1 enfant sur 100 et 1 adulte sur 1000 trait\u00e9s par lamotrigine.<\/li>\n<li>Les femmes sont plus \u00e0 risque que les hommes.<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td>Acide valpro\u00efque<\/td>\n<td>\n<ul>\n<li>Diaphor\u00e8se (transpiration excessive, <span class=\"term\" data-term-id=\"1928\">hyperhidrose<\/span>)<\/li>\n<li>\u00c9ryth\u00e8me polymorphe<\/li>\n<li>Transitoire <span class=\"term\" data-term-id=\"824\">alop\u00e9cie<\/span> (Chute de cheveux)<\/li>\n<li><span class=\"term\" data-term-id=\"229\">Petechiae<\/span><\/li>\n<li>Photosensibilit\u00e9<\/li>\n<li>Prurit<\/li>\n<\/ul>\n<\/td>\n<td>\n<ul>\n<li>Il interagit avec d&#039;autres anticonvulsivants comme la lamotrigine, augmentant la possibilit\u00e9 d&#039;effets secondaires.<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2><span class=\"ez-toc-section\" id=\"Genetico-predisposicion-a-Reacciones-adversas-a-los-anticonvulsivos\"><\/span>\n<span class=\"term\" data-term-id=\"558\">G\u00e9n\u00e9tique<\/span> <span class=\"term\" data-term-id=\"1494\">pr\u00e9disposition<\/span> \u00e0 <span class=\"term\" data-term-id=\"1333\">Effets ind\u00e9sirables<\/span> aux anticonvulsivants<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Certains groupes raciaux sont particuli\u00e8rement sujets \u00e0 des r\u00e9actions cutan\u00e9es ind\u00e9sirables avec des anticonvulsivants. Test pour un individu <span class=\"term\" data-term-id=\"529\">allele<\/span> Avant le d\u00e9but d&#039;un anticonvulsivant, il peut \u00eatre utile d&#039;identifier les patients \u00e0 risque.<\/p>\n<ul>\n<li>Han chinois et autres groupes d&#039;Asie du Sud-Est qui ont un <span class=\"term\" data-term-id=\"1245\">HLA<\/span>-All\u00e8le B, <em>HLA-B * 1502<\/em> ils sont beaucoup plus susceptibles de d\u00e9velopper des r\u00e9actions s\u00e9v\u00e8res telles que le syndrome de Stevens-Johnson et la n\u00e9crolyse \u00e9pidermique toxique (NET) avec des anticonvulsivants. <\/li>\n<li>Les populations japonaise, cor\u00e9enne et blanche aux \u00c9tats-Unis et en Europe qui portent <em>HLA-A * 31: 01<\/em> Ils ont \u00e9galement tendance \u00e0 d\u00e9velopper des <span class=\"term\" data-term-id=\"1334\">Effets ind\u00e9sirables du m\u00e9dicament<\/span> avec des anticonvulsivants <\/li>\n<\/ul>\n<\/section>","protected":false},"excerpt":{"rendered":"<p>Introducci\u00f3n Muchas drogas pueden causar cut\u00e1neo (piel) efectos secundarios. La gravedad de los s\u00edntomas puede variar desde un leve erupci\u00f3n a afecciones potencialmente mortales que causan insuficiencia cut\u00e1nea y muerte&#8230;.<\/p>","protected":false},"author":8,"featured_media":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","format":"standard","meta":{"footnotes":""},"categories":[204],"tags":[],"class_list":["post-7001","wiki","type-wiki","status-publish","format-standard","category-glosario-definiciones"],"_links":{"self":[{"href":"https:\/\/doctorhoogstra.com\/fr\/wp-json\/wp\/v2\/wiki\/7001","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/doctorhoogstra.com\/fr\/wp-json\/wp\/v2\/wiki"}],"about":[{"href":"https:\/\/doctorhoogstra.com\/fr\/wp-json\/wp\/v2\/types\/wiki"}],"author":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/fr\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/fr\/wp-json\/wp\/v2\/comments?post=7001"}],"version-history":[{"count":0,"href":"https:\/\/doctorhoogstra.com\/fr\/wp-json\/wp\/v2\/wiki\/7001\/revisions"}],"wp:attachment":[{"href":"https:\/\/doctorhoogstra.com\/fr\/wp-json\/wp\/v2\/media?parent=7001"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/fr\/wp-json\/wp\/v2\/categories?post=7001"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/fr\/wp-json\/wp\/v2\/tags?post=7001"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}