{"id":7656,"date":"2020-04-25T08:55:21","date_gmt":"2020-04-25T11:55:21","guid":{"rendered":"https:\/\/doctorhoogstra.com\/es\/patologia-del-histiocitoma-epitelioide\/"},"modified":"2020-04-30T21:09:03","modified_gmt":"2020-05-01T00:09:03","slug":"epithelioide-histiocytome-pathologie","status":"publish","type":"wiki","link":"https:\/\/doctorhoogstra.com\/fr\/wiki\/patologia-del-histiocitoma-epitelioide\/","title":{"rendered":"Pathologie de l&#039;histiocytome \u00e9pith\u00e9lio\u00efde."},"content":{"rendered":"<p><\/p><div id=\"ez-toc-container\" class=\"ez-toc-v2_0_88 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Contenu<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Basculer la table des mati\u00e8res\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Basculer<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 eztoc-toggle-hide-by-default' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/doctorhoogstra.com\/fr\/wiki\/patologia-del-histiocitoma-epitelioide\/#Histologia-del-histiocitoma-epitelioide\" >Histologie de l&#039;histiocytome \u00e9pith\u00e9lio\u00efde<\/a><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/doctorhoogstra.com\/fr\/wiki\/patologia-del-histiocitoma-epitelioide\/#Patologia-del-histiocitoma-epitelioide\" >Pathologie de l&#039;histiocytome \u00e9pith\u00e9lio\u00efde.<\/a><\/li><\/ul><\/li><\/ul><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/doctorhoogstra.com\/fr\/wiki\/patologia-del-histiocitoma-epitelioide\/#Estudios-especiales-para-el-histiocitoma-epitelioide\" >\u00c9tudes sp\u00e9ciales pour l&#039;histiocytome \u00e9pith\u00e9lio\u00efde.<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/doctorhoogstra.com\/fr\/wiki\/patologia-del-histiocitoma-epitelioide\/#Diagnostico-diferencial-del-histiocitoma-epitelioide-patologia\" >Diagnostic diff\u00e9rentiel de la pathologie des histiocytomes \u00e9pith\u00e9lio\u00efdes<\/a><\/li><\/ul><\/nav><\/div>\n\n<section class=\"textBlock\">\n<p><span class=\"term\" data-term-id=\"1667\">\u00c9pith\u00e9lio\u00efde<\/span> L&#039;histiocytome cellulaire est une variante bien <span class=\"term\" data-term-id=\"47\">cutan\u00e9<\/span> histiocytome fibreux qui peut \u00eatre confondu avec un autre <span class=\"term\" data-term-id=\"22\">b\u00e9nin<\/span> et <span class=\"term\" data-term-id=\"176\">le mal<\/span> L\u00e9sions m\u00e9senchymateuses. Il est \u00e9galement connu sous le nom d&#039;histiocytome \u00e9pith\u00e9lio\u00efde fibreux et de dermatofibrome \u00e9pith\u00e9lio\u00efde.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Histologia-del-histiocitoma-epitelioide\"><\/span>\n<span class=\"term\" data-term-id=\"128\">Histologie<\/span> d&#039;histiocytome \u00e9pith\u00e9lio\u00efde<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Dans l&#039;histiocytome \u00e9pith\u00e9lio\u00efde, les coupes montrent une localisation centrale, <span class=\"term\" data-term-id=\"37\">circonscrit<\/span> <span class=\"term\" data-term-id=\"289\">tumeur<\/span> sous-jacent \u00e0 <span class=\"term\" data-term-id=\"846\">\u00e9pidermique<\/span> col (figure 1). La tumeur est constitu\u00e9e de cellules \u00e9pith\u00e9lio\u00efdes en couches et parfois d&#039;un motif orageux. Les cellules individuelles montrent une abondance <span class=\"term\" data-term-id=\"449\">\u00e9osinophile<\/span> <span class=\"term\" data-term-id=\"838\">cytoplasme<\/span> avec rond <span class=\"term\" data-term-id=\"1029\">v\u00e9siculaire<\/span> <span class=\"term\" data-term-id=\"729\">noyaux<\/span> et des nucl\u00e9oles pro\u00e9minents (figures 2-4). Les cellules peuvent \u00eatre sensiblement agrandies et pr\u00e9senter certaines <span class=\"term\" data-term-id=\"1612\">nucl\u00e9aire<\/span> <span class=\"term\" data-term-id=\"1305\">atypie<\/span> (Figure 4).<\/p>\n<p>Il y a souvent un associ\u00e9 <span class=\"term\" data-term-id=\"490\">inflammatoire<\/span> cellule <span class=\"term\" data-term-id=\"541\">infiltrer<\/span> qui peut \u00eatre utile pour le diagnostic (figure 3). Certains <span class=\"term\" data-term-id=\"1535\">mitose<\/span> peut \u00eatre vu <span class=\"term\" data-term-id=\"736\">Multinucl\u00e9\u00e9<\/span> <span class=\"term\" data-term-id=\"739\">cellules g\u00e9antes<\/span> et <span class=\"term\" data-term-id=\"119\">h\u00e9mosmosine<\/span> <span class=\"term\" data-term-id=\"370\">d\u00e9claration<\/span> Parfois, ils sont \u00e9galement vus.<\/p>\n<section class=\"textBlock imageLinkBlockTitle\">\n<h5 class=\"colour--primary\"><span class=\"ez-toc-section\" id=\"Patologia-del-histiocitoma-epitelioide\"><\/span>Pathologie de l&#039;histiocytome \u00e9pith\u00e9lio\u00efde.<span class=\"ez-toc-section-end\"><\/span><\/h5>\n<\/section>\n<section class=\"imageLinkBlock\">\n<div class=\"flex\">\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='\u00e9pith\u00e9lio\u00efde-histiocytome-figure-1__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-6180257-5079828' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/epithelioid-histiocytoma-figure-1__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-6180257.jpg'>\n<\/div>\n<p class=\"p-small\">Figure 1<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='\u00e9pith\u00e9lio\u00efde-histiocytome-figure-2__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-8273265-6832771' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/epithelioid-histiocytoma-figure-2__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-8273265.jpg'>\n<\/div>\n<p class=\"p-small\">Figure 2<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='\u00e9pith\u00e9lio\u00efde-histiocytome-figure-3__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-8153107-6194443' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/epithelioid-histiocytoma-figure-3__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-8153107.jpg'>\n<\/div>\n<p class=\"p-small\">figure 3<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='\u00e9pith\u00e9lio\u00efde-histiocytome-figure-4__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-4164670-5049539' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/epithelioid-histiocytoma-figure-4__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-4164670.jpg'>\n<\/div>\n<p class=\"p-small\">Figure 4<\/p>\n<\/p><\/div>\n<\/section>\n<div class=\"clearfix imageLinkBlock\"><\/div>\n<h2><span class=\"ez-toc-section\" id=\"Estudios-especiales-para-el-histiocitoma-epitelioide\"><\/span>\u00c9tudes sp\u00e9ciales pour l&#039;histiocytome \u00e9pith\u00e9lio\u00efde.<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Les \u00e9tudes immunohistochimiques r\u00e9v\u00e8lent une positivit\u00e9 avec le facteur 13a et une positivit\u00e9 variable avec le CD68. <span>ALK-1 est de plus en plus reconnu comme translocalis\u00e9 dans cette tumeur. Cela peut \u00eatre d\u00e9tect\u00e9 avec <span class=\"term\" data-term-id=\"1421\">immunohistochimie<\/span> ou <span class=\"term\" data-term-id=\"1237\">POISSON<\/span>.<\/span><\/p>\n<div id=\"square-placement-country-holder\" class=\"country-dependent advert\">\n<div class=\"box-placement square-placement\">\n<div class=\"advert__frame\">\n<div id=\"dermnet-dermnet-mobbox\">\n<\/div><\/div><\/div><\/div>\n<h2><span class=\"ez-toc-section\" id=\"Diagnostico-diferencial-del-histiocitoma-epitelioide-patologia\"><\/span>\n<span class=\"term\" data-term-id=\"813\">Diagnostic diff\u00e9rentiel<\/span> d&#039;histiocytome \u00e9pith\u00e9lio\u00efde <span class=\"term\" data-term-id=\"223\">pathologie<\/span><br \/>\n<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span class=\"term\" data-term-id=\"1670\">M\u00e9lanome<\/span> &#8211; <span class=\"term\" data-term-id=\"1061\">Am\u00e9lanotique<\/span> le m\u00e9lanome montrera de grandes cellules \u00e9pith\u00e9lio\u00efdes similaires mais montrera g\u00e9n\u00e9ralement plus <span class=\"term\" data-term-id=\"1539\">pl\u00e9omorphisme<\/span> et atteinte \u00e9pidermique. La positivit\u00e9 S100 est observ\u00e9e dans le m\u00e9lanome.<\/p>\n<p>\u00c9pith\u00e9lio\u00efde <span class=\"term\" data-term-id=\"1665\">sarcome<\/span> &#8211; <span class=\"term\" data-term-id=\"113\">Granulome<\/span>clusters de type avec <span class=\"term\" data-term-id=\"403\">n\u00e9crose<\/span>plus d&#039;atypie <span class=\"term\" data-term-id=\"155\">freiner<\/span>+.<\/p>\n<p>Un autre \u00e9pith\u00e9lio\u00efde <span class=\"term\" data-term-id=\"52\">dermique<\/span> tumeurs: des \u00e9tudes immunohistochimiques peuvent aider \u00e0 exclure l&#039;\u00e9pith\u00e9lio\u00efde <span class=\"term\" data-term-id=\"753\">vasculaire<\/span>, muscle lisse et <span class=\"term\" data-term-id=\"859\">histiocytaire<\/span> tumeurs<\/p>\n<\/section>","protected":false},"excerpt":{"rendered":"<p>Epitelioide El histiocitoma celular es una variante bien reconocida de cut\u00e1neo histiocitoma fibroso que puede confundirse con otro benigno y maligno Lesiones mesenquimales. Tambi\u00e9n se conoce como histiocitoma fibroso epitelioide&#8230;<\/p>","protected":false},"author":8,"featured_media":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","format":"standard","meta":{"footnotes":""},"categories":[204],"tags":[205],"class_list":["post-7656","wiki","type-wiki","status-publish","format-standard","category-glosario-definiciones","tag-patologia"],"_links":{"self":[{"href":"https:\/\/doctorhoogstra.com\/fr\/wp-json\/wp\/v2\/wiki\/7656","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/doctorhoogstra.com\/fr\/wp-json\/wp\/v2\/wiki"}],"about":[{"href":"https:\/\/doctorhoogstra.com\/fr\/wp-json\/wp\/v2\/types\/wiki"}],"author":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/fr\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/fr\/wp-json\/wp\/v2\/comments?post=7656"}],"version-history":[{"count":0,"href":"https:\/\/doctorhoogstra.com\/fr\/wp-json\/wp\/v2\/wiki\/7656\/revisions"}],"wp:attachment":[{"href":"https:\/\/doctorhoogstra.com\/fr\/wp-json\/wp\/v2\/media?parent=7656"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/fr\/wp-json\/wp\/v2\/categories?post=7656"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/fr\/wp-json\/wp\/v2\/tags?post=7656"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}