{"id":7898,"date":"2020-04-26T07:55:12","date_gmt":"2020-04-26T10:55:12","guid":{"rendered":"https:\/\/doctorhoogstra.com\/es\/dermatitis-herpetiforme-patologia\/"},"modified":"2020-10-30T07:09:49","modified_gmt":"2020-10-30T10:09:49","slug":"dermatite-herpetiforme-pathologie","status":"publish","type":"wiki","link":"https:\/\/doctorhoogstra.com\/fr\/wiki\/dermatitis-herpetiforme-patologia\/","title":{"rendered":"Dermatite herp\u00e9tiforme pathologie"},"content":{"rendered":"<p><\/p><div id=\"ez-toc-container\" class=\"ez-toc-v2_0_89 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Contenu<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Basculer la table des mati\u00e8res\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Basculer<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 eztoc-toggle-hide-by-default' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/doctorhoogstra.com\/fr\/wiki\/dermatitis-herpetiforme-patologia\/#Histologia-de-dermatitis-herpetiforme\" >Histologie de la dermatite herp\u00e9tiforme<\/a><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/doctorhoogstra.com\/fr\/wiki\/dermatitis-herpetiforme-patologia\/#Dermatitis-herpetiforme-patologia\" >Dermatite herp\u00e9tiforme pathologie<\/a><\/li><\/ul><\/li><\/ul><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/doctorhoogstra.com\/fr\/wiki\/dermatitis-herpetiforme-patologia\/#Variantes-de-dermatitis-herpetiforme\" >Variantes de la dermatite herp\u00e9tiforme<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/doctorhoogstra.com\/fr\/wiki\/dermatitis-herpetiforme-patologia\/#Manchas-especiales-en-dermatitis-herpetiforme\" >Taches sp\u00e9ciales dans la dermatite herp\u00e9tiforme.<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/doctorhoogstra.com\/fr\/wiki\/dermatitis-herpetiforme-patologia\/#Diagnostico-diferencial-de-dermatitis-herpetiforme\" >Diagnostic diff\u00e9rentiel de la dermatite herp\u00e9tiforme<\/a><\/li><\/ul><\/nav><\/div>\n\n<section class=\"textBlock\">\n<h2><span class=\"ez-toc-section\" id=\"Histologia-de-dermatitis-herpetiforme\"><\/span>\n<span class=\"term\" data-term-id=\"128\">Histologie<\/span> de <span class=\"term\" data-term-id=\"53\">dermatite<\/span> herp\u00e9tiforme<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Le pouvoir de balayage de la dermatite herp\u00e9tiforme montre <span class=\"term\" data-term-id=\"1029\">v\u00e9siculaire<\/span> sch\u00e9ma de r\u00e9action (figure 1), caract\u00e9ris\u00e9 par des foyers ou de petites zones de s\u00e9paration sous-\u00e9pidermique (figures 2 et 3). Grappes denses de <span class=\"term\" data-term-id=\"196\"><span class=\"term\" data-term-id=\"442\">neutrophiles<\/span><\/span>  et dispers\u00e9 <span class=\"term\" data-term-id=\"448\">\u00e9osinophiles<\/span> remplir la papille <span class=\"term\" data-term-id=\"61\">derme<\/span> formant <span class=\"term\" data-term-id=\"1454\">microabc\u00e8s<\/span> (Figure 4). <span class=\"term\" data-term-id=\"1344\">Acantolytique<\/span> <span class=\"term\" data-term-id=\"1069\">k\u00e9ratinocytes<\/span> peut \u00e9galement \u00eatre \u00e9vident au sein de la papillaire <span class=\"term\" data-term-id=\"1453\">microabc\u00e8s<\/span> (Figure 4). Au fil du temps, les petites zones de la papille <span class=\"term\" data-term-id=\"52\">dermique<\/span> la s\u00e9paration peut se rejoindre pour former de plus grandes zones de v\u00e9sicules.<\/p>\n<section class=\"textBlock imageLinkBlockTitle\">\n<h5 class=\"colour--primary\"><span class=\"ez-toc-section\" id=\"Dermatitis-herpetiforme-patologia\"><\/span>Dermatite herp\u00e9tiforme pathologie<span class=\"ez-toc-section-end\"><\/span><\/h5>\n<\/section>\n<section class=\"imageLinkBlock\">\n<div class=\"flex\">\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='dhfigure1__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisinkildi0xq-6089140-7643384' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/dhfigure1__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsInkiLDI0XQ-6089140.jpg'>\n<\/div>\n<p class=\"p-small\">Figure 1<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='dhfigure2__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-8679736-3606566' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/dhfigure2__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-8679736.jpg'>\n<\/div>\n<p class=\"p-small\">Figure 2<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='dhfigure3__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-2009681-1136456' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/dhfigure3__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-2009681.jpg'>\n<\/div>\n<p class=\"p-small\">figure 3<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='dhfigure4__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-7118472-3420433' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/dhfigure4__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-7118472.jpg'>\n<\/div>\n<p class=\"p-small\">Figure 4<\/p>\n<\/p><\/div>\n<\/section>\n<div class=\"clearfix imageLinkBlock\"><\/div>\n<h2><span class=\"ez-toc-section\" id=\"Variantes-de-dermatitis-herpetiforme\"><\/span>Variantes de la dermatite herp\u00e9tiforme<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>P\u00e9nfigo herpetiforme: estrictamente una variante del <a href=\"https:\/\/doctorhoogstra.com\/fr\/tipos-tratamientos\/lesiones-de-la-piel\/\" class=\"wpil_internal_link\" style=\"display: inline !important;width: auto !important\" data-wpil-post-to-id=\"\">p\u00e9nfigo,<\/a> se menciona aqu\u00ed ya que puede presentarse como un imitador cl\u00ednico de la dermatitis herpetiforme. La histolog\u00eda es la del p\u00e9nfigo, t\u00edpicamente de tipo foli\u00e1ceo, con formaci\u00f3n de <span class=\"term\" data-term-id=\"1038\">intra\u00e9pidermique<\/span> <span class=\"term\" data-term-id=\"1028\">v\u00e9sicules<\/span>.<\/p>\n<div id=\"square-placement-country-holder\" class=\"country-dependent advert\">\n<div class=\"box-placement square-placement\">\n<div class=\"advert__frame\">\n<div id=\"dermnet-dermnet-mobbox\">\n<\/div><\/div><\/div><\/div>\n<h2><span class=\"ez-toc-section\" id=\"Manchas-especiales-en-dermatitis-herpetiforme\"><\/span>Taches sp\u00e9ciales dans la dermatite herp\u00e9tiforme.<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Direct <span class=\"term\" data-term-id=\"142\">immunofluorescence<\/span> des \u00e9tudes montrent des d\u00e9p\u00f4ts d&#039;IgA granulaires dans le derme <span class=\"term\" data-term-id=\"374\">papilles<\/span>.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Diagnostico-diferencial-de-dermatitis-herpetiforme\"><\/span>\n<span class=\"term\" data-term-id=\"813\">Diagnostic diff\u00e9rentiel<\/span> dermatite herp\u00e9tiforme<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Virus de l&#039;herp\u00e8s <span class=\"term\" data-term-id=\"145\">infection<\/span>: Malgr\u00e9 la pr\u00e9sence occasionnelle de k\u00e9ratinocytes acantholytiques, la dermatite herp\u00e9tiforme ne montre pas <span class=\"term\" data-term-id=\"737\">multinucl\u00e9ation<\/span>, <span class=\"term\" data-term-id=\"1612\">nucl\u00e9aire<\/span> <span class=\"term\" data-term-id=\"1528\">chromatine<\/span> changements ou <span class=\"term\" data-term-id=\"956\">cellulaire<\/span> <span class=\"term\" data-term-id=\"1832\">inclusions<\/span>.<\/p>\n<p><span class=\"term\" data-term-id=\"321\">Lin\u00e9aire<\/span> IgA <span class=\"term\" data-term-id=\"498\">bulleux<\/span> <span class=\"term\" data-term-id=\"60\">maladie de peau<\/span>: Les <span class=\"term\" data-term-id=\"474\">histologique<\/span> bien que les r\u00e9sultats soient largement identiques <span class=\"term\" data-term-id=\"3\">acantholyse<\/span> et <span class=\"term\" data-term-id=\"850\">fibrine<\/span> au bout des papilles dermiques et <span class=\"term\" data-term-id=\"1386\">leucocytose<\/span> Elle est plus fr\u00e9quente dans les dermatites herp\u00e9tiformes. Les r\u00e9sultats de l&#039;immunofluorescence montreront une coloration lin\u00e9aire de la membrane basale IgA.<\/p>\n<p>Lupus \u00e9ryth\u00e9mateux bulleux: l&#039;histologie peut \u00eatre identique \u00e0 une discrimination uniquement possible lorsque des IgG et IgM lin\u00e9aires sont trouv\u00e9es dans la membrane basale. Les d\u00e9p\u00f4ts d&#039;IgA peuvent \u00e9galement \u00eatre visualis\u00e9s simultan\u00e9ment. Fr\u00e9quemment la papillaire cutan\u00e9e <span class=\"term\" data-term-id=\"443\">neutrophile<\/span> <span class=\"term\" data-term-id=\"541\">infiltrer<\/span> on le voit se propager vers les environs <span class=\"term\" data-term-id=\"693\">interstice<\/span>.<\/p>\n<p><span class=\"term\" data-term-id=\"36\">Cicatriciel<\/span> pemphigo\u00efde: dans les l\u00e9sions papillaires pr\u00e9coces <span class=\"term\" data-term-id=\"1\">abc\u00e8s<\/span> vous pouvez voir la formation bien que le <span class=\"term\" data-term-id=\"449\">\u00e9osinophile<\/span> la population augmente avec <span class=\"term\" data-term-id=\"164\">blessure<\/span> heure. La principale caract\u00e9ristique distinctive est la pr\u00e9sence de cicatrices cutan\u00e9es sous l&#039;ampoule. L&#039;immunofluorescence diff\u00e8re \u00e9galement avec les IgG lin\u00e9aires g\u00e9n\u00e9ralement observ\u00e9es sur la membrane basale. Des cas exceptionnels peuvent montrer des IgA <span class=\"term\" data-term-id=\"370\">d\u00e9claration<\/span> seul.<\/p>\n<\/section>","protected":false},"excerpt":{"rendered":"<p>Histolog\u00eda de dermatitis herpetiforme El poder de exploraci\u00f3n de la dermatitis herpetiforme muestra vesicular patr\u00f3n de reacci\u00f3n (Figura 1), caracterizado por focos o peque\u00f1as zonas de separaci\u00f3n subepid\u00e9rmica (Figuras 2&#8230;<\/p>","protected":false},"author":8,"featured_media":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","format":"standard","meta":{"footnotes":""},"categories":[204],"tags":[205],"class_list":["post-7898","wiki","type-wiki","status-publish","format-standard","category-glosario-definiciones","tag-patologia"],"_links":{"self":[{"href":"https:\/\/doctorhoogstra.com\/fr\/wp-json\/wp\/v2\/wiki\/7898","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/doctorhoogstra.com\/fr\/wp-json\/wp\/v2\/wiki"}],"about":[{"href":"https:\/\/doctorhoogstra.com\/fr\/wp-json\/wp\/v2\/types\/wiki"}],"author":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/fr\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/fr\/wp-json\/wp\/v2\/comments?post=7898"}],"version-history":[{"count":0,"href":"https:\/\/doctorhoogstra.com\/fr\/wp-json\/wp\/v2\/wiki\/7898\/revisions"}],"wp:attachment":[{"href":"https:\/\/doctorhoogstra.com\/fr\/wp-json\/wp\/v2\/media?parent=7898"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/fr\/wp-json\/wp\/v2\/categories?post=7898"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/fr\/wp-json\/wp\/v2\/tags?post=7898"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}