{"id":8123,"date":"2020-04-27T06:36:32","date_gmt":"2020-04-27T09:36:32","guid":{"rendered":"https:\/\/doctorhoogstra.com\/es\/patologia-de-la-enfermedad-de-paget-extramamaria\/"},"modified":"2020-04-30T21:08:57","modified_gmt":"2020-05-01T00:08:57","slug":"pathologie-de-la-maladie-extramammaire-paget","status":"publish","type":"wiki","link":"https:\/\/doctorhoogstra.com\/fr\/wiki\/patologia-de-la-enfermedad-de-paget-extramamaria\/","title":{"rendered":"Pathologie de la maladie de Paget extramammaire"},"content":{"rendered":"<p><\/p><div id=\"ez-toc-container\" class=\"ez-toc-v2_0_88 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Contenu<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Basculer la table des mati\u00e8res\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Basculer<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 eztoc-toggle-hide-by-default' ><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/doctorhoogstra.com\/fr\/wiki\/patologia-de-la-enfermedad-de-paget-extramamaria\/#Cancer-de-piel\" >Cancer de la peau<\/a><\/li><\/ul><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/doctorhoogstra.com\/fr\/wiki\/patologia-de-la-enfermedad-de-paget-extramamaria\/#Introduccion\" >introduction<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/doctorhoogstra.com\/fr\/wiki\/patologia-de-la-enfermedad-de-paget-extramamaria\/#Histologia-de-la-enfermedad-de-Paget-extramamaria\" >Histologie de la maladie de Paget extramammaire<\/a><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/doctorhoogstra.com\/fr\/wiki\/patologia-de-la-enfermedad-de-paget-extramamaria\/#Patologia-de-la-enfermedad-de-Paget-extramamaria\" >Pathologie de la maladie de Paget extramammaire<\/a><\/li><\/ul><\/li><\/ul><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/doctorhoogstra.com\/fr\/wiki\/patologia-de-la-enfermedad-de-paget-extramamaria\/#Estudios-especiales-de-la-enfermedad-de-Paget-extramamaria\" >\u00c9tudes sp\u00e9ciales sur la maladie de Paget extramammaire<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/doctorhoogstra.com\/fr\/wiki\/patologia-de-la-enfermedad-de-paget-extramamaria\/#Diagnostico-diferencial-de-la-enfermedad-de-Paget-extramamaria\" >Diagnostic diff\u00e9rentiel de la maladie de Paget extramammaire<\/a><\/li><\/ul><\/nav><\/div>\n\n<section class=\"textBlock\">\n<div class=\"cmsBlock\">\n<div class=\"cmsBlock__shortcode\">\n<section class=\"textBlock\">\n<p><img alt='miiskin-3-2-133__scalewidthwzewmf0-8268734-6234750' class=\"right\" title=\"\" src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/miiskin-3-2-133__ScaleWidthWzEwMF0-8268734.jpg' width=\"100\" height=\"100\"><\/p>\n<blockquote>\n<p style=\"text-align: center\"><em>Un d<\/em><\/p>\n<h4><span class=\"ez-toc-section\" id=\"Cancer-de-piel\"><\/span>Cancer de la peau<span class=\"ez-toc-section-end\"><\/span><\/h4>\n<p><strong>Application pour faciliter l&#039;auto-examen de la peau et la d\u00e9tection pr\u00e9coce<\/strong>. <strong><span style=\"text-decoration: underline\">Lire la suite<\/span>.<\/strong><\/p>\n<\/blockquote>\n<\/section>\n<div class=\"clearfix\"><\/div>\n<\/div>\n<div class=\"cmsBlock__title\">Texte: Miiskin.<\/div>\n<\/div>\n<h2><span class=\"ez-toc-section\" id=\"Introduccion\"><\/span>introduction<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>La maladie de Paget extramammaire de la peau est une <span class=\"term\" data-term-id=\"1742\">malignit\u00e9<\/span>associ\u00e9e \u00e0 une maladie de la peau caract\u00e9ris\u00e9e par un <span class=\"term\" data-term-id=\"492\">ecz\u00e9mateux<\/span> <span class=\"term\" data-term-id=\"255\">\u00e9ruption<\/span> du <span class=\"term\" data-term-id=\"825\">anog\u00e9nital<\/span> r\u00e9gion et <span class=\"term\" data-term-id=\"1004\">vulve<\/span>, o\u00f9 il y a une abondance de <span class=\"term\" data-term-id=\"12\">glandes apocrines<\/span>. <span class=\"term\" data-term-id=\"949\">Primaire<\/span> <span class=\"term\" data-term-id=\"47\">cutan\u00e9<\/span> il existe des formes associ\u00e9es au sous-jacent <span class=\"term\" data-term-id=\"1827\">attach\u00e9<\/span> <span class=\"term\" data-term-id=\"32\">carcinome<\/span>, en plus des formes associ\u00e9es \u00e0 un ad\u00e9nocarcinome sous-jacent anal, rectal ou v\u00e9sical. La maladie de Paget extramammaire peut pr\u00e9c\u00e9der la tumeur maligne associ\u00e9e jusqu&#039;\u00e0 15 ans.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Histologia-de-la-enfermedad-de-Paget-extramamaria\"><\/span>\n<span class=\"term\" data-term-id=\"128\">Histologie<\/span> de la maladie de Paget extramammaire<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Paget <span class=\"term\" data-term-id=\"289\">tumeur<\/span> Les cellules se trouvent dans le <span class=\"term\" data-term-id=\"85\">\u00e9piderme<\/span> (Figure 1-3). Dans de rares cas, les cellules tumorales peuvent se propager <span class=\"term\" data-term-id=\"61\">derme<\/span>. Dans les l\u00e9sions ant\u00e9rieures, les cellules de Paget se trouvent pr\u00e8s de la membrane basale et s\u2019\u00e9tendent pour remplir tout l\u2019\u00e9piderme \u00e0 mesure que la maladie progresse. Les cellules tumorales sont volumineuses, claires ou <span class=\"term\" data-term-id=\"449\">\u00e9osinophile<\/span> <span class=\"term\" data-term-id=\"838\">cytoplasme<\/span>, grand <span class=\"term\" data-term-id=\"1540\">pl\u00e9omorphe<\/span> <span class=\"term\" data-term-id=\"729\">noyaux<\/span> et occasionnel <span class=\"term\" data-term-id=\"1535\">mitose<\/span> (Figure 3). <span class=\"term\" data-term-id=\"610\">Hyperk\u00e9ratose<\/span> et <span class=\"term\" data-term-id=\"218\">parak\u00e9ratose<\/span> peut se chevaucher <span class=\"term\" data-term-id=\"1449\">agr\u00e9gats<\/span> de cellules tumorales (Figure 2). <span class=\"term\" data-term-id=\"136\">Hyperplasie<\/span> de l&#039;\u00e9piderme peut \u00eatre <span class=\"term\" data-term-id=\"270\">squameux<\/span>, <span class=\"term\" data-term-id=\"216\">papillomateux<\/span> ou <span class=\"term\" data-term-id=\"1652\">fibro\u00e9pith\u00e9liome<\/span> par Pinkus-like. <span class=\"term\" data-term-id=\"1278\">Ulc\u00e9ration<\/span> et <span class=\"term\" data-term-id=\"1521\">pigmentation<\/span> peuvent \u00eatre pr\u00e9sents. <span class=\"term\" data-term-id=\"52\">Dermique<\/span> Les changements comprennent un <span class=\"term\" data-term-id=\"319\">chronique<\/span> <span class=\"term\" data-term-id=\"490\">inflammatoire<\/span> <span class=\"term\" data-term-id=\"541\">infiltrer<\/span> (Figures 1, 2). Un carcinome annexiel sous-jacent peut \u00eatre pr\u00e9sent.<\/p>\n<section class=\"textBlock imageLinkBlockTitle\">\n<h5 class=\"colour--primary\"><span class=\"ez-toc-section\" id=\"Patologia-de-la-enfermedad-de-Paget-extramamaria\"><\/span>Pathologie de la maladie de Paget extramammaire<span class=\"ez-toc-section-end\"><\/span><\/h5>\n<\/section>\n<section class=\"imageLinkBlock\">\n<div class=\"flex\">\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='pagetsfigure1__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-1345494-4410927' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/pagetsfigure1__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-1345494.jpg'>\n<\/div>\n<p class=\"p-small\">Figure 1<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='pagetsfigure2__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-1837460-4462802' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/pagetsfigure2__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-1837460.jpg'>\n<\/div>\n<p class=\"p-small\">Figure 2<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='pagetsfigure3__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-1089725-2402696' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/pagetsfigure3__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-1089725.jpg'>\n<\/div>\n<p class=\"p-small\">figure 3<\/p>\n<\/p><\/div>\n<\/section>\n<div class=\"clearfix imageLinkBlock\"><\/div>\n<div id=\"square-placement-country-holder\" class=\"country-dependent advert\"><\/div>\n<h2><span class=\"ez-toc-section\" id=\"Estudios-especiales-de-la-enfermedad-de-Paget-extramamaria\"><\/span>\u00c9tudes sp\u00e9ciales sur la maladie de Paget extramammaire<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Les cellules tumorales contiennent en abondance <span class=\"term\" data-term-id=\"1636\">mucine<\/span> qui peut \u00eatre identifi\u00e9 par coloration au bleu Alcian et \u00e0 l&#039;acide p\u00e9riodique Schiff (PAS). Sur le plan immunohistochimique, les cellules de Paget se colorent pour <span class=\"term\" data-term-id=\"847\">\u00e9pith\u00e9lium<\/span> membrane <span class=\"term\" data-term-id=\"410\">antig\u00e8ne<\/span> (EMA), faible <span class=\"term\" data-term-id=\"1851\">mol\u00e9culaire<\/span> poids <span class=\"term\" data-term-id=\"1613\">cytok\u00e9ratines<\/span> (CK7+) et CD23 \u00e0 positivit\u00e9 variable pour l&#039;antig\u00e8ne carcinoembryonnaire (CEA). Les cytok\u00e9ratines de haut poids mol\u00e9culaire colorent l&#039;\u00e9piderme environnant et mettent en \u00e9vidence les cellules Paget n\u00e9gatives.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Diagnostico-diferencial-de-la-enfermedad-de-Paget-extramamaria\"><\/span>\n<span class=\"term\" data-term-id=\"813\">Diagnostic diff\u00e9rentiel<\/span> de la maladie de Paget extramammaire<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Maladie de Paget mammaire de la peau\u00a0: Cette affection est cutan\u00e9e <span class=\"term\" data-term-id=\"164\">blessure<\/span> provenant d&#039;un conduit sous-jacent <span class=\"term\" data-term-id=\"1077\">sur place<\/span> carcinome du sein. La maladie de Paget extramammaire ne pr\u00e9sente pas l&#039;expression Her-2\/neu observ\u00e9e dans la maladie de Paget mammaire. Les tumeurs du sein et les tumeurs provenant des glandes apocrines sont color\u00e9es au GCDFP-15.<\/p>\n<p><span class=\"term\" data-term-id=\"1670\">M\u00e9lanome<\/span> <span class=\"term\" data-term-id=\"863\">sur place<\/span> \u2013 contrairement \u00e0 Paget, le m\u00e9lanome est n\u00e9gatif pour les cytok\u00e9ratines, l&#039;EMA et le CEA. S100, HMB-45 et MART-1 sont g\u00e9n\u00e9ralement n\u00e9gatifs dans la maladie de Paget et positifs dans le m\u00e9lanome.<\/p>\n<p>Carcinome \u00e9pidermo\u00efde (CSC) in situ (<span class=\"term\" data-term-id=\"1038\">intra\u00e9pidermique<\/span> carcinome) \u2013 P63 est positif dans les CSC in situ, se diff\u00e9renciant de Paget. <span class=\"term\" data-term-id=\"1614\">Cytokeratin<\/span> sept peuvent \u00eatre positifs \u00e0 la fois dans le CSC de Paget et in situ.<\/p>\n<p><span class=\"term\" data-term-id=\"262\">S\u00e9bac\u00e9<\/span> carcinome in situ \u2013 adipophiline positive, CEA n\u00e9gative, GCDFP-15 n\u00e9gative.<\/p>\n<\/section>","protected":false},"excerpt":{"rendered":"<p>Anuncio C\u00e1ncer de piel Aplicaci\u00f3n para facilitar el autoexamen de la piel y la detecci\u00f3n temprana. Lee mas. Texto: Miiskin. Introducci\u00f3n La enfermedad de Paget extramamaria de la piel es&#8230;<\/p>","protected":false},"author":8,"featured_media":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","format":"standard","meta":{"footnotes":""},"categories":[204],"tags":[205],"class_list":["post-8123","wiki","type-wiki","status-publish","format-standard","category-glosario-definiciones","tag-patologia"],"_links":{"self":[{"href":"https:\/\/doctorhoogstra.com\/fr\/wp-json\/wp\/v2\/wiki\/8123","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/doctorhoogstra.com\/fr\/wp-json\/wp\/v2\/wiki"}],"about":[{"href":"https:\/\/doctorhoogstra.com\/fr\/wp-json\/wp\/v2\/types\/wiki"}],"author":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/fr\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/fr\/wp-json\/wp\/v2\/comments?post=8123"}],"version-history":[{"count":0,"href":"https:\/\/doctorhoogstra.com\/fr\/wp-json\/wp\/v2\/wiki\/8123\/revisions"}],"wp:attachment":[{"href":"https:\/\/doctorhoogstra.com\/fr\/wp-json\/wp\/v2\/media?parent=8123"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/fr\/wp-json\/wp\/v2\/categories?post=8123"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/fr\/wp-json\/wp\/v2\/tags?post=8123"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}