{"id":16543,"date":"2020-04-28T17:49:23","date_gmt":"2020-04-28T20:49:23","guid":{"rendered":"https:\/\/doctorhoogstra.com\/es\/wiki\/patologia-del-sarcoma-de-kaposi\/"},"modified":"2020-04-30T21:27:23","modified_gmt":"2020-05-01T00:27:23","slug":"patologia-do-sarcoma-de-kaposi","status":"publish","type":"wiki","link":"https:\/\/doctorhoogstra.com\/pt\/wiki\/patologia-del-sarcoma-de-kaposi\/","title":{"rendered":"Patologia do sarcoma de Kaposi"},"content":{"rendered":"<p><\/p><div id=\"ez-toc-container\" class=\"ez-toc-v2_0_88 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Conte\u00fado<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Alternar tabela de conte\u00fado\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Alternar<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 eztoc-toggle-hide-by-default' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/doctorhoogstra.com\/pt\/wiki\/patologia-del-sarcoma-de-kaposi\/#Introduccion\" >Introdu\u00e7\u00e3o<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/doctorhoogstra.com\/pt\/wiki\/patologia-del-sarcoma-de-kaposi\/#Histologia-del-sarcoma-de-Kaposi\" >Histologia do Sarcoma de Kaposi<\/a><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/doctorhoogstra.com\/pt\/wiki\/patologia-del-sarcoma-de-kaposi\/#Patologia-del-sarcoma-de-Kaposi\" >Patologia do sarcoma de Kaposi<\/a><\/li><\/ul><\/li><\/ul><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/doctorhoogstra.com\/pt\/wiki\/patologia-del-sarcoma-de-kaposi\/#Histologico-variantes-del-sarcoma-de-Kaposi\" >Variantes histol\u00f3gicas do sarcoma de Kaposi<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/doctorhoogstra.com\/pt\/wiki\/patologia-del-sarcoma-de-kaposi\/#Pruebas-especiales-en-el-sarcoma-de-Kaposi\" >Testes especiais no sarcoma de Kaposi.<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/doctorhoogstra.com\/pt\/wiki\/patologia-del-sarcoma-de-kaposi\/#Diagnostico-diferencial-del-sarcoma-de-Kaposi\" >Diagn\u00f3stico diferencial do sarcoma de Kaposi<\/a><\/li><\/ul><\/nav><\/div>\n\n<section class=\"textBlock\">\n<h2><span class=\"ez-toc-section\" id=\"Introduccion\"><\/span>Introdu\u00e7\u00e3o<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Kaposi <span class=\"term\" data-term-id=\"1665\">sarcoma<\/span> isto \u00e9 <span class=\"term\" data-term-id=\"116\">agrupado<\/span> dentro <span class=\"term\" data-term-id=\"753\">vascular<\/span> tumores vari\u00e1veis <span class=\"term\" data-term-id=\"176\">maligno<\/span> comportamento. a <span class=\"term\" data-term-id=\"128\">histologia<\/span> \u00c9 tipicamente muito distinto. As caracter\u00edsticas mudam dependendo da natureza do <span class=\"term\" data-term-id=\"164\">ferimentos<\/span> clinicamente \u00e0 medida que progride <span class=\"term\" data-term-id=\"224\">fragmento<\/span> para <span class=\"term\" data-term-id=\"235\">placa de carro<\/span> para <span class=\"term\" data-term-id=\"733\">nodular<\/span> Est\u00e1gio.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Histologia-del-sarcoma-de-Kaposi\"><\/span>Histologia do Sarcoma de Kaposi<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>A vis\u00e3o de baixo poder da histologia do sarcoma de Kaposi \u00e9 de uma <span class=\"term\" data-term-id=\"956\">celular<\/span> <span class=\"term\" data-term-id=\"52\">d\u00e9rmico<\/span> <span class=\"term\" data-term-id=\"198\">n\u00f3dulo<\/span> (Figura 1). Pode haver v\u00e1rios graus de sobreposi\u00e7\u00e3o <span class=\"term\" data-term-id=\"846\">epid\u00e9rmico<\/span> mudan\u00e7as que podem variar de proeminentes <span class=\"term\" data-term-id=\"610\">hiperceratose<\/span> e <span class=\"term\" data-term-id=\"2\">acantose<\/span> Franco <span class=\"term\" data-term-id=\"1278\">ulcera\u00e7\u00e3o<\/span>. a pele <span class=\"term\" data-term-id=\"893\">prolifera\u00e7\u00e3o<\/span> \u00e9 composto por um <span class=\"term\" data-term-id=\"1659\">c\u00e9lula do eixo<\/span> prolifera\u00e7\u00e3o de <span class=\"term\" data-term-id=\"758\">endotelial<\/span> c\u00e9lulas que formam espa\u00e7os vasculares sinuosos. Estas podem ser escassas nas les\u00f5es em fase de remendo, progredindo para <span class=\"term\" data-term-id=\"1674\">fasc\u00edculos<\/span> do <span class=\"term\" data-term-id=\"1660\">c\u00e9lulas fusiformes<\/span> nas les\u00f5es nodulares (Figuras 2,3). Este padr\u00e3o fascicular foi comparado a cardumes de peixes. c\u00e9lulas fusiformes <span class=\"term\" data-term-id=\"541\">infiltrar<\/span> atrav\u00e9s de <span class=\"term\" data-term-id=\"39\">col\u00e1geno<\/span>, formando espa\u00e7os tipo fenda, principalmente na periferia das les\u00f5es (Figura 4). Onde embarca\u00e7\u00f5es rec\u00e9m-formadas se projetam em um espa\u00e7o existente, o promont\u00f3rio <span class=\"term\" data-term-id=\"899\">placa<\/span> visto (Figura 5). Isso agora \u00e9 reconhecido como n\u00e3o espec\u00edfico para essa condi\u00e7\u00e3o.<\/p>\n<p>Nas les\u00f5es em placa e no est\u00e1gio nodular, pode haver <span class=\"term\" data-term-id=\"1684\">intracelular<\/span> e extracelular <span class=\"term\" data-term-id=\"1602\">hialino<\/span> gl\u00f3bulos, embora para representar engolido <span class=\"term\" data-term-id=\"696\">eritr\u00f3citos<\/span>. Embora raro, isso pode ser visto em les\u00f5es em est\u00e1gio de remendo. Coram PAS positivo. Embora a prolifera\u00e7\u00e3o endotelial seja comum <span class=\"term\" data-term-id=\"325\">monom\u00f3rfico<\/span>, pode ser significativo <span class=\"term\" data-term-id=\"1612\">nuclear<\/span> <span class=\"term\" data-term-id=\"1305\">atypia<\/span> com mais <span class=\"term\" data-term-id=\"1536\">mit\u00f3tico<\/span> atividade (Figura 6). Quando atipia proeminente \u00e9 vista <span class=\"term\" data-term-id=\"289\">tumor<\/span> enquadra-se na categoria de <span class=\"term\" data-term-id=\"1327\">anapl\u00e1sico<\/span> variante.<\/p>\n<p>a <span class=\"term\" data-term-id=\"490\">inflamat\u00f3rio<\/span> o infiltrado \u00e9 predominantemente <span class=\"term\" data-term-id=\"422\">linfoc\u00edtico<\/span> com dispersos <span class=\"term\" data-term-id=\"1513\">plasma<\/span> As c\u00e9lulas tamb\u00e9m s\u00e3o uma pista para esse diagn\u00f3stico. Os gl\u00f3bulos vermelhos s\u00e3o vistos dentro dos espa\u00e7os em forma de fenda e em todo o tumor. \u00c0s vezes, na base e na periferia do Kaposi nodular, pode haver grandes vasos cavernosos.<\/p>\n<section class=\"textBlock imageLinkBlockTitle\">\n<h5 class=\"colour--primary\"><span class=\"ez-toc-section\" id=\"Patologia-del-sarcoma-de-Kaposi\"><\/span>Patologia do sarcoma de Kaposi<span class=\"ez-toc-section-end\"><\/span><\/h5>\n<\/section>\n<section class=\"imageLinkBlock\">\n<div class=\"flex\">\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='kaposisfigure1__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisinkildbd-7250901-9416101' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/KaposisFigure1__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsInkiLDBd-7250901.jpg'>\n<\/div>\n<p class=\"p-small\">figura 1<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='kaposisfigure2__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-5734811-9409644' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/KaposisFigure2__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-5734811.jpg'>\n<\/div>\n<p class=\"p-small\">Figura 2<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='kaposisfigure3__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-6189025-5118940' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/KaposisFigure3__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-6189025.jpg'>\n<\/div>\n<p class=\"p-small\">Figura 3<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='kaposisfigure5__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-8589958-3226545' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/KaposisFigure5__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-8589958.jpg'>\n<\/div>\n<p class=\"p-small\">Figura 4<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='kaposisfigure6__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-5660565-9674462' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/KaposisFigure6__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-5660565.jpg'>\n<\/div>\n<p class=\"p-small\">Figura 5<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='kaposisfigure7__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-9905460-5424057' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/KaposisFigure7__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-9905460.jpg'>\n<\/div>\n<p class=\"p-small\">Figura 6<\/p>\n<\/p><\/div>\n<\/section>\n<div class=\"clearfix imageLinkBlock\"><\/div>\n<div id=\"square-placement-country-holder\" class=\"country-dependent advert\">\n<div class=\"box-placement square-placement\">\n<div class=\"advert__frame\">\n<div id=\"dermnet-dermnet-mobbox\">\n<\/div><\/div><\/div><\/div>\n<h2><span class=\"ez-toc-section\" id=\"Histologico-variantes-del-sarcoma-de-Kaposi\"><\/span>\n<span class=\"term\" data-term-id=\"474\">Histol\u00f3gico<\/span> Variantes do sarcoma de Kaposi<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>In\u00fameras varia\u00e7\u00f5es patol\u00f3gicas foram descritas para o sarcoma de Kaposi, dependendo da natureza das caracter\u00edsticas adicionais associadas ou do padr\u00e3o de prolifera\u00e7\u00e3o d\u00e9rmica. Eles s\u00e3o amplamente intuitivos na descri\u00e7\u00e3o da les\u00e3o. As variantes relatadas incluem:<\/p>\n<ul>\n<li>Anapl\u00e1stico<\/li>\n<li>telangiect\u00e1sica<\/li>\n<li>linfedematoso<\/li>\n<li><span class=\"term\" data-term-id=\"1470\">Hiperquerat\u00f3tico<\/span><\/li>\n<li>queloide<\/li>\n<li>micronodular<\/li>\n<li>\n<span class=\"term\" data-term-id=\"254\">Pyogenic<\/span> <span class=\"term\" data-term-id=\"113\">granuloma<\/span>-eu gosto<\/li>\n<li>equim\u00f3tico<\/li>\n<li><span class=\"term\" data-term-id=\"1162\">Intravascular<\/span><\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"Pruebas-especiales-en-el-sarcoma-de-Kaposi\"><\/span>Testes especiais no sarcoma de Kaposi.<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>As c\u00e9lulas lesionais no sarcoma de Kaposi s\u00e3o positivas para os marcadores endoteliais inespec\u00edficos CD31 (Figura 7) e CD34, e tamb\u00e9m para o <span class=\"term\" data-term-id=\"744\">linf\u00e1tico<\/span> marcador endotelial D2-40 ou podoplanina. a <span class=\"term\" data-term-id=\"425\">anticorpo<\/span> para HHV-8 (Herpesv\u00edrus Humano 8) <span class=\"term\" data-term-id=\"1040\">latente<\/span> nuclear <span class=\"term\" data-term-id=\"410\">ant\u00edgeno<\/span> 1 \u00e9 um corante comercial altamente espec\u00edfico e tem diagn\u00f3stico simplificado em casos dif\u00edceis. Figura 8.<\/p>\n<section class=\"imageLinkBlock\">\n<div class=\"flex\">\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='kaposisfigure8cd31__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-3104040-1436221' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/KaposisFigure8CD31__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-3104040.jpg'>\n<\/div>\n<p class=\"p-small\">Figura 7<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='kaposisfigure9hhv8__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-9697596-6550583' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/KaposisFigure9HHV8__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-9697596.jpg'>\n<\/div>\n<p class=\"p-small\">Figura 8<\/p>\n<\/p><\/div>\n<\/section>\n<div class=\"clearfix imageLinkBlock\"><\/div>\n<h2><span class=\"ez-toc-section\" id=\"Diagnostico-diferencial-del-sarcoma-de-Kaposi\"><\/span>\n<span class=\"term\" data-term-id=\"813\">Diagn\u00f3stico diferencial<\/span> Sarcoma de Kaposi<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>microvenular <span class=\"term\" data-term-id=\"360\">hemangioma<\/span>: Este tumor vascular pode ser dif\u00edcil de distinguir clinicamente de les\u00f5es em placas em est\u00e1gio inicial. Navios menos bem formados, presen\u00e7a de energia nuclear. <span class=\"term\" data-term-id=\"1539\">pleomorfismo<\/span> e positivo <span class=\"term\" data-term-id=\"1421\">imuno-histoqu\u00edmica<\/span> HHV-8 \u00e9 compat\u00edvel com sarcoma de Kaposi.<\/p>\n<p>Hemangioma em tufos: M\u00faltiplos lobos de c\u00e9lulas fusiformes s\u00e3o observados, mas n\u00e3o apresentam o padr\u00e3o de entrela\u00e7amento do sarcoma de Kaposi ou a forma\u00e7\u00e3o de um canal vascular em forma de fenda.<\/p>\n<p>Sarcoma de Pseudo-Kaposi (acroangiodermatite): Enquanto no diferencial do sarcoma de Kaposi em est\u00e1gio inicial, a acroangiodermatite consiste em uma prolifera\u00e7\u00e3o regular de pequenos vasos sem o aspecto sinuoso do sarcoma de Kaposi.<\/p>\n<p>Hemangioma cavernoso: pode ser considerado quando h\u00e1 vasos dilatados na base ou na periferia das les\u00f5es no est\u00e1gio nodular, mas esse hemangioma n\u00e3o possui um componente de c\u00e9lulas fusiformes.<\/p>\n<p>Granuloma piog\u00eanico: Geralmente apenas um problema em les\u00f5es de bi\u00f3psia parcial onde apenas o componente superficial da les\u00e3o \u00e9 demonstrado.<\/p>\n<\/section>","protected":false},"excerpt":{"rendered":"<p>Introducci\u00f3n Kaposi sarcoma es agrupado dentro vascular tumores de variable maligno comportamiento. los histolog\u00eda Es t\u00edpicamente muy distintivo. Las caracter\u00edsticas cambian dependiendo de la naturaleza del lesi\u00f3n cl\u00ednicamente a medida&#8230;<\/p>","protected":false},"author":8,"featured_media":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","format":"standard","meta":{"footnotes":""},"categories":[204],"tags":[205],"class_list":["post-16543","wiki","type-wiki","status-publish","format-standard","category-glosario-definiciones","tag-patologia"],"_links":{"self":[{"href":"https:\/\/doctorhoogstra.com\/pt\/wp-json\/wp\/v2\/wiki\/16543","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/doctorhoogstra.com\/pt\/wp-json\/wp\/v2\/wiki"}],"about":[{"href":"https:\/\/doctorhoogstra.com\/pt\/wp-json\/wp\/v2\/types\/wiki"}],"author":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/pt\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/pt\/wp-json\/wp\/v2\/comments?post=16543"}],"version-history":[{"count":0,"href":"https:\/\/doctorhoogstra.com\/pt\/wp-json\/wp\/v2\/wiki\/16543\/revisions"}],"wp:attachment":[{"href":"https:\/\/doctorhoogstra.com\/pt\/wp-json\/wp\/v2\/media?parent=16543"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/pt\/wp-json\/wp\/v2\/categories?post=16543"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/pt\/wp-json\/wp\/v2\/tags?post=16543"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}