{"id":6952,"date":"2020-04-23T21:21:15","date_gmt":"2020-04-24T00:21:15","guid":{"rendered":"https:\/\/doctorhoogstra.com\/es\/linfoma-extranodal-de-celulas-nk-t-tipo-nasal-patologia\/"},"modified":"2020-05-03T18:25:15","modified_gmt":"2020-05-03T21:25:15","slug":"extranodal-linfoma-de-celulas-nk-t-nasal-type-pathology","status":"publish","type":"wiki","link":"https:\/\/doctorhoogstra.com\/pt\/wiki\/linfoma-extranodal-de-celulas-nk-t-tipo-nasal-patologia\/","title":{"rendered":"Linfoma extranodal de c\u00e9lulas NK \/ T, tipo nasal, patologia"},"content":{"rendered":"<p><\/p><div id=\"ez-toc-container\" class=\"ez-toc-v2_0_88 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Conte\u00fado<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Alternar tabela de conte\u00fado\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Alternar<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 eztoc-toggle-hide-by-default' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/doctorhoogstra.com\/pt\/wiki\/linfoma-extranodal-de-celulas-nk-t-tipo-nasal-patologia\/#Introduccion\" >Introdu\u00e7\u00e3o<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/doctorhoogstra.com\/pt\/wiki\/linfoma-extranodal-de-celulas-nk-t-tipo-nasal-patologia\/#Histologia-del-linfoma-extraganglionar-de-celulas-NK-T-tipo-nasal\" >Histologia do linfoma extranodal de c\u00e9lulas NK\/T, tipo nasal<\/a><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/doctorhoogstra.com\/pt\/wiki\/linfoma-extranodal-de-celulas-nk-t-tipo-nasal-patologia\/#Linfoma-extranodal-de-celulas-NK-T-patologia-de-tipo-nasal\" >Linfoma de c\u00e9lulas NK\/T extranodais, patologia do tipo nasal<\/a><\/li><\/ul><\/li><\/ul><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/doctorhoogstra.com\/pt\/wiki\/linfoma-extranodal-de-celulas-nk-t-tipo-nasal-patologia\/#Estudios-especiales-para-el-linfoma-extranodal-de-celulas-NK-T-tipo-nasal\" >Estudos especiais para linfoma extranodal de c\u00e9lulas NK\/T, tipo nasal<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/doctorhoogstra.com\/pt\/wiki\/linfoma-extranodal-de-celulas-nk-t-tipo-nasal-patologia\/#Diagnostico-diferencial-del-linfoma-extraganglionar-de-celulas-NK-T-tipo-nasal\" >Diagn\u00f3stico Diferencial de Linfoma de C\u00e9lulas NK\/T Extranodais, Tipo Nasal<\/a><\/li><\/ul><\/nav><\/div>\n\n<section class=\"textBlock\">\n<h2><span class=\"ez-toc-section\" id=\"Introduccion\"><\/span>Introdu\u00e7\u00e3o<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span class=\"term\" data-term-id=\"1790\">Extranodal<\/span> NK \/<span class=\"term\" data-term-id=\"416\">C\u00e9lula T<\/span> <span class=\"term\" data-term-id=\"976\">linfoma<\/span>, tipo nasal, \u00e9 uma doen\u00e7a causada pelo v\u00edrus Epstein-Barr (EBV) que geralmente afeta principalmente o trato respirat\u00f3rio superior (ver <span>Associado ao v\u00edrus Epstein-Barr <span class=\"term\" data-term-id=\"1402\">linfoproliferativo<\/span> desordens)<\/span>. A pele est\u00e1 secundariamente envolvida, mas tamb\u00e9m podem ocorrer doen\u00e7as baseadas principalmente na pele.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Histologia-del-linfoma-extraganglionar-de-celulas-NK-T-tipo-nasal\"><\/span>\n<span class=\"term\" data-term-id=\"128\">Histologia<\/span> de linfoma extranodal de c\u00e9lulas NK\/T, tipo nasal<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>No linfoma extranodal de c\u00e9lulas NK\/T, tipo nasal, h\u00e1 uma densidade <span class=\"term\" data-term-id=\"52\">d\u00e9rmico<\/span> <span class=\"term\" data-term-id=\"541\">infiltrar<\/span> (figura 1) que muitas vezes se estende <span class=\"term\" data-term-id=\"1282\">subcutis<\/span>. <span class=\"term\" data-term-id=\"96\">Exocitose<\/span> do <span class=\"term\" data-term-id=\"1395\">at\u00edpico<\/span> <span class=\"term\" data-term-id=\"421\">linf\u00f3citos<\/span> no <span class=\"term\" data-term-id=\"85\">epiderme<\/span> pode ser visto e pode se assemelhar muito \u00e0 micose fung\u00f3ide (figura 2). O infiltrado em <span class=\"term\" data-term-id=\"61\">derme<\/span> \u00c9 geralmente <span class=\"term\" data-term-id=\"1064\">polimorfo<\/span> e pode incluir muitos <span class=\"term\" data-term-id=\"858\">histi\u00f3citos<\/span> e <span class=\"term\" data-term-id=\"448\">eosin\u00f3filos<\/span>. As c\u00e9lulas at\u00edpicas s\u00e3o de tamanho pequeno a m\u00e9dio com algumas formas maiores (figuras 3, 4). Geralmente o infiltrado <span class=\"term\" data-term-id=\"542\">infiltradores<\/span> As paredes do vaso (figuras 3, 4) causam <span class=\"term\" data-term-id=\"753\">vascular<\/span>. <span class=\"term\" data-term-id=\"1612\">Nuclear<\/span> detritos (visto focalmente na figura 4) e <span class=\"term\" data-term-id=\"403\">necrose<\/span> \u00c9 outro achado comum.<\/p>\n<section class=\"textBlock imageLinkBlockTitle\">\n<h5 class=\"colour--primary\"><span class=\"ez-toc-section\" id=\"Linfoma-extranodal-de-celulas-NK-T-patologia-de-tipo-nasal\"><\/span>Linfoma de c\u00e9lulas NK\/T extranodais, patologia do tipo nasal<span class=\"ez-toc-section-end\"><\/span><\/h5>\n<\/section>\n<section class=\"imageLinkBlock\">\n<div class=\"flex\">\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='nktcell-fig-1__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-6895891-4574380' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/nktcell-fig-1__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-6895891.jpg'>\n<\/div>\n<p class=\"p-small\">figura 1<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='nktcell-fig-2__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-6230121-7337598' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/nktcell-fig-2__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-6230121.jpg'>\n<\/div>\n<p class=\"p-small\">Figura 2<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='nktcell-fig-3__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-5759367-4621543' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/nktcell-fig-3__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-5759367.jpg'>\n<\/div>\n<p class=\"p-small\">Figura 3<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='nktcell-fig-4__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-7441658-2716878' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/nktcell-fig-4__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-7441658.jpg'>\n<\/div>\n<p class=\"p-small\">Figura 4<\/p>\n<\/p><\/div>\n<\/section>\n<div class=\"clearfix imageLinkBlock\"><\/div>\n<div id=\"square-placement-country-holder\" class=\"country-dependent advert\">\n<div class=\"box-placement square-placement\">\n<div class=\"advert__frame\">\n<div id=\"dermnet-dermnet-mobbox\">\n<\/div><\/div><\/div><\/div>\n<h2><span class=\"ez-toc-section\" id=\"Estudios-especiales-para-el-linfoma-extranodal-de-celulas-NK-T-tipo-nasal\"><\/span>Estudos especiais para linfoma extranodal de c\u00e9lulas NK\/T, tipo nasal<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Colora\u00e7\u00f5es especiais s\u00e3o essenciais para fazer o diagn\u00f3stico. <span class=\"term\" data-term-id=\"1077\">No lugar<\/span> A hibridiza\u00e7\u00e3o com EBV mostra que as c\u00e9lulas at\u00edpicas s\u00e3o positivas. As c\u00e9lulas at\u00edpicas s\u00e3o geralmente positivas com <span class=\"term\" data-term-id=\"1421\">imuno-histoqu\u00edmica<\/span> para CD56 e granzima ou TIA1. Alguns casos expressar\u00e3o a <span class=\"term\" data-term-id=\"631\">C\u00e9lula T<\/span> marcador CD3. c\u00e9lula T <span class=\"term\" data-term-id=\"774\">gene<\/span> Os estudos de reorganiza\u00e7\u00e3o geralmente s\u00e3o negativos.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Diagnostico-diferencial-del-linfoma-extraganglionar-de-celulas-NK-T-tipo-nasal\"><\/span>\n<span class=\"term\" data-term-id=\"813\">Diagn\u00f3stico diferencial<\/span> de linfoma extranodal de c\u00e9lulas NK\/T, tipo nasal<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>De outros <span class=\"term\" data-term-id=\"1374\">perif\u00e9rico<\/span> Linfomas de c\u00e9lulas T e <span class=\"term\" data-term-id=\"900\">subcut\u00e2neo<\/span> <span class=\"term\" data-term-id=\"213\">paniculite<\/span>-like linfoma de c\u00e9lulas T pode assemelhar-se a este linfoma. Estudos de rearranjo g\u00eanico de c\u00e9lulas T positivos e estudos imuno-histoqu\u00edmicos de c\u00e9lulas T positivos favoreceriam um linfoma de c\u00e9lulas T. EBV, CD56 e express\u00e3o de granzima s\u00e3o achados incomuns em outros linfomas de c\u00e9lulas T.<\/p>\n<\/section>","protected":false},"excerpt":{"rendered":"<p>Introducci\u00f3n Extranodal NK \/c\u00e9lula T linfoma, tipo nasal, es una enfermedad impulsada por el virus de Epstein-Barr (VEB) que generalmente afecta principalmente el tracto respiratorio superior (ver Asociado al virus&#8230;<\/p>","protected":false},"author":8,"featured_media":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","format":"standard","meta":{"footnotes":""},"categories":[204],"tags":[205],"class_list":["post-6952","wiki","type-wiki","status-publish","format-standard","category-glosario-definiciones","tag-patologia"],"_links":{"self":[{"href":"https:\/\/doctorhoogstra.com\/pt\/wp-json\/wp\/v2\/wiki\/6952","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/doctorhoogstra.com\/pt\/wp-json\/wp\/v2\/wiki"}],"about":[{"href":"https:\/\/doctorhoogstra.com\/pt\/wp-json\/wp\/v2\/types\/wiki"}],"author":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/pt\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/pt\/wp-json\/wp\/v2\/comments?post=6952"}],"version-history":[{"count":0,"href":"https:\/\/doctorhoogstra.com\/pt\/wp-json\/wp\/v2\/wiki\/6952\/revisions"}],"wp:attachment":[{"href":"https:\/\/doctorhoogstra.com\/pt\/wp-json\/wp\/v2\/media?parent=6952"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/pt\/wp-json\/wp\/v2\/categories?post=6952"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/pt\/wp-json\/wp\/v2\/tags?post=6952"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}