{"id":6993,"date":"2020-04-24T01:31:02","date_gmt":"2020-04-24T04:31:02","guid":{"rendered":"https:\/\/doctorhoogstra.com\/es\/inhibidores-del-factor-de-necrosis-tumoral\/"},"modified":"2020-04-27T16:34:47","modified_gmt":"2020-04-27T19:34:47","slug":"inhibidores-del-factor-de-necrosis-tumoral","status":"publish","type":"wiki","link":"https:\/\/doctorhoogstra.com\/pt\/wiki\/inhibidores-del-factor-de-necrosis-tumoral\/","title":{"rendered":"Inibidores do fator de necrose tumoral"},"content":{"rendered":"<p><\/p><div id=\"ez-toc-container\" class=\"ez-toc-v2_0_88 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Conte\u00fado<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Alternar tabela de conte\u00fado\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Alternar<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 eztoc-toggle-hide-by-default' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/doctorhoogstra.com\/pt\/wiki\/inhibidores-del-factor-de-necrosis-tumoral\/#%C2%BFQue-son-los-antitumor-necrosis-drogas-alfa\" >\u00bfQu\u00e9 son los antitumor necrosis drogas alfa?<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/doctorhoogstra.com\/pt\/wiki\/inhibidores-del-factor-de-necrosis-tumoral\/#Otras-drogas-anti-TNF\" >Otras drogas anti-TNF<\/a><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/doctorhoogstra.com\/pt\/wiki\/inhibidores-del-factor-de-necrosis-tumoral\/#Condiciones-de-la-piel-tratadas-con-inhibidores-del-factor-de-necrosis-tumoral\" >Condiciones de la piel tratadas con inhibidores del factor de necrosis tumoral<\/a><\/li><\/ul><\/li><\/ul><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/doctorhoogstra.com\/pt\/wiki\/inhibidores-del-factor-de-necrosis-tumoral\/#%C2%BFCuales-son-los-riesgos-de-los-medicamentos-anti-TNF\" >\u00bfCu\u00e1les son los riesgos de los medicamentos anti-TNF?<\/a><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/doctorhoogstra.com\/pt\/wiki\/inhibidores-del-factor-de-necrosis-tumoral\/#Efectos-secundarios-dermatologicos-de-los-inhibidores-del-factor-de-necrosis-tumoral\" >Efectos secundarios dermatol\u00f3gicos de los inhibidores del factor de necrosis tumoral<\/a><\/li><\/ul><\/li><\/ul><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n\n<section class=\"textBlock\">\n<h2><span class=\"ez-toc-section\" id=\"%C2%BFQue-son-los-antitumor-necrosis-drogas-alfa\"><\/span>\u00bfQu\u00e9 son los anti<span class=\"term\" data-term-id=\"289\">tumor<\/span> <span class=\"term\" data-term-id=\"403\">necrose<\/span> drogas alfa?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>El factor de necrosis tumoral (TNF) es un <span class=\"term\" data-term-id=\"433\">citocina<\/span> associado com <span class=\"term\" data-term-id=\"490\">inflamat\u00f3rio<\/span> trastornos de la piel, articulaciones y tracto gastrointestinal. <\/p>\n<p>Los medicamentos anti-TNF m\u00e1s activos son <span class=\"term\" data-term-id=\"466\">monoclonal<\/span> <span class=\"term\" data-term-id=\"426\">anticorpos<\/span> dirigido contra TNF-alfa (TNF\u03b1). Medicamentos anti-TNF\u03b1 <span class=\"term\" data-term-id=\"1854\">ao controle<\/span> <span class=\"term\" data-term-id=\"148\">inflama\u00e7\u00e3o<\/span> en enfermedades inflamatorias de la piel, <span class=\"term\" data-term-id=\"1578\">artrite<\/span>y enfermedad intestinal. Estaban entre los primeros agentes biol\u00f3gicos en el mercado.<\/p>\n<p>Los anticuerpos monoclonales anti-TNF\u03b1 incluyen:<\/p>\n<ul>\n<li>Infliximab<\/li>\n<li>Adalimumab<\/li>\n<li>Etanercept<\/li>\n<li>Golimumab<\/li>\n<li>Certolizumab<\/li>\n<\/ul>\n<h3><span class=\"ez-toc-section\" id=\"Otras-drogas-anti-TNF\"><\/span>Otras drogas anti-TNF<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Otros medicamentos con actividad contra el TNF incluyen:<\/p>\n<ul>\n<li>Talidomida<\/li>\n<li>Sulfassalazina<\/li>\n<li>Pentoxifilina<\/li>\n<li>Bupropion <\/li>\n<\/ul>\n<p><span>Los compuestos naturales que act\u00faan contra el TNF incluyen:<\/span><\/p>\n<ul>\n<li>Catequinas<\/li>\n<li>Curcumina<\/li>\n<li>Canabis<\/li>\n<li>Echinacea purpurea<\/li>\n<\/ul>\n<p>\u00bfPara qu\u00e9 afecciones de la piel se usan los anti-TNF?<\/p>\n<p>Los anticuerpos monoclonales anti-TNF se utilizan principalmente en el tratamiento de enfermedades graves. <span class=\"term\" data-term-id=\"319\">cr\u00f4nica<\/span> <span class=\"term\" data-term-id=\"235\">placa de carro<\/span> psoriasis. Tambi\u00e9n se usan para otras enfermedades inflamatorias severas de la piel cuando las terapias convencionales han fallado. Ejemplos incluyen:<\/p>\n<ul>\n<li>Hidradenite supurativa<\/li>\n<li>Enfermedad de la piel asociada con la enfermedad de Crohn.<\/li>\n<li>\n<span class=\"term\" data-term-id=\"1626\">Pioderma<\/span> gangrenoso y PAPA <span class=\"term\" data-term-id=\"350\">s\u00edndrome<\/span> (sin marca)<\/li>\n<\/ul>\n<section class=\"textBlock imageLinkBlockTitle\">\n<h5 class=\"colour--primary\"><span class=\"ez-toc-section\" id=\"Condiciones-de-la-piel-tratadas-con-inhibidores-del-factor-de-necrosis-tumoral\"><\/span>Condiciones de la piel tratadas con inhibidores del factor de necrosis tumoral<span class=\"ez-toc-section-end\"><\/span><\/h5>\n<\/section>\n<section class=\"imageLinkBlock\">\n<div class=\"flex\">\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='severe-psoriasis__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-8613792-1580661' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/severe-psoriasis__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-8613792.jpg'>\n<\/div>\n<p class=\"p-small\">Psor\u00edase grave<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='hidradenitis-suppurativa__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisinkildg1xq-9530745-4026129' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/hidradenitis-suppurativa__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsInkiLDg1XQ-9530745.jpg'>\n<\/div>\n<p class=\"p-small\">Hidradenite supurativa<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='pyoderma-gangrenosum__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildbd-3018887-6385581' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/pyoderma-gangrenosum__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDBd-3018887.jpg'>\n<\/div>\n<p class=\"p-small\">Pioderma gangrenoso<\/p>\n<\/p><\/div>\n<\/section>\n<div class=\"clearfix imageLinkBlock\"><\/div>\n<h2><span class=\"ez-toc-section\" id=\"%C2%BFCuales-son-los-riesgos-de-los-medicamentos-anti-TNF\"><\/span>\u00bfCu\u00e1les son los riesgos de los medicamentos anti-TNF?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Los biol\u00f3gicos anti-TNF se administran por inyecci\u00f3n. A veces pueden causar reacciones en el lugar de inyecci\u00f3n o reacciones a la infusi\u00f3n. Deben evitarse en pacientes con insuficiencia card\u00edaca grave.<\/p>\n<p>El principal riesgo de la terapia anti-TNF es la inmunidad reducida a <span class=\"term\" data-term-id=\"937\">bacteriano<\/span>, infecciones f\u00fangicas, virales y parasitarias, que incluyen:<\/p>\n<ul>\n<li>Tuberculose<\/li>\n<li>Histoplasmose<\/li>\n<li>Coccidioidomicose<\/li>\n<li>Blastomicose<\/li>\n<\/ul>\n<p>Tambi\u00e9n pueden aumentar los riesgos de c\u00e1ncer de piel y <span class=\"term\" data-term-id=\"691\">autoimune<\/span> enfermedades, incluidas afecciones desmielinizantes.<\/p>\n<p>Los medicamentos anti-TNF pueden perder su efecto con el tiempo, posiblemente debido a la inducci\u00f3n de anticuerpos contra ellos. Parad\u00f3jicamente, los anti-TNF a veces pueden provocar efectos secundarios dermatol\u00f3gicos, como:<\/p>\n<ul>\n<li><span class=\"term\" data-term-id=\"1475\">Palmoplantar<\/span> <span class=\"term\" data-term-id=\"1130\">pustulose<\/span><\/li>\n<li>Diversas formas de psoriasis\n<\/li>\n<li><span class=\"term\" data-term-id=\"491\">Eczema<\/span><\/li>\n<li>L\u00fapus eritematoso<\/li>\n<li>Morph<\/li>\n<li><span class=\"term\" data-term-id=\"824\">Alopecia<\/span> areata<\/li>\n<li>Vitiligo<\/li>\n<li><span class=\"term\" data-term-id=\"113\">Granuloma<\/span> cancelar<\/li>\n<li>Sarcoidose<\/li>\n<li><span class=\"term\" data-term-id=\"90\">Eritema<\/span> multiforme<\/li>\n<li><span class=\"term\" data-term-id=\"1091\">Vasculite<\/span><\/li>\n<li>S\u00edndrome de Stevens-Johnson &#8211; <span class=\"term\" data-term-id=\"1159\">t\u00f3xico<\/span> <span class=\"term\" data-term-id=\"846\">epid\u00e9rmico<\/span> necr\u00f3lise<\/li>\n<li>\n<p>Numular inducido por f\u00e1rmacos <span class=\"term\" data-term-id=\"53\">dermatite<\/span> <\/li>\n<\/ul>\n<section class=\"textBlock imageLinkBlockTitle\">\n<h5 class=\"colour--primary\"><span class=\"ez-toc-section\" id=\"Efectos-secundarios-dermatologicos-de-los-inhibidores-del-factor-de-necrosis-tumoral\"><\/span>Efectos secundarios dermatol\u00f3gicos de los inhibidores del factor de necrosis tumoral<span class=\"ez-toc-section-end\"><\/span><\/h5>\n<\/section>\n<section class=\"imageLinkBlock\">\n<div class=\"flex\">\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='hand-dermatitis-atnf__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-1201172-7000900' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/hand-dermatitis-aTNF__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-1201172.jpg'>\n<\/div>\n<p class=\"p-small\">Dermatite da m\u00e3o<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='nummular-dermatitis-atnf__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-4995964-1799611' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/nummular-dermatitis-aTNF__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-4995964.jpg'>\n<\/div>\n<p class=\"p-small\">Dermatite numular<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='alopecia-areata-atnf__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-3212141-1340217' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/alopecia-areata-aTNF__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-3212141.jpg'>\n<\/div>\n<p class=\"p-small\">Alopecia areata<\/p>\n<\/p><\/div>\n<\/section>\n<div class=\"clearfix imageLinkBlock\"><\/div>\n<div class=\"grey-box\"><em><span style=\"font-size: 0.9em;\">As folhas de dados aprovadas da Nova Zel\u00e2ndia s\u00e3o a fonte oficial de informa\u00e7\u00f5es para esses medicamentos controlados, incluindo usos aprovados e informa\u00e7\u00f5es de risco. Veja a folha de dados individual da Nova Zel\u00e2ndia no site da Medsafe.<\/span><\/em><\/div>\n<\/section>","protected":false},"excerpt":{"rendered":"<p>\u00bfQu\u00e9 son los antitumor necrosis drogas alfa? El factor de necrosis tumoral (TNF) es un citocina asociado con inflamatorio trastornos de la piel, articulaciones y tracto gastrointestinal. Los medicamentos anti-TNF&#8230;<\/p>","protected":false},"author":8,"featured_media":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","format":"standard","meta":{"footnotes":""},"categories":[204],"tags":[],"class_list":["post-6993","wiki","type-wiki","status-publish","format-standard","category-glosario-definiciones"],"_links":{"self":[{"href":"https:\/\/doctorhoogstra.com\/pt\/wp-json\/wp\/v2\/wiki\/6993","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/doctorhoogstra.com\/pt\/wp-json\/wp\/v2\/wiki"}],"about":[{"href":"https:\/\/doctorhoogstra.com\/pt\/wp-json\/wp\/v2\/types\/wiki"}],"author":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/pt\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/pt\/wp-json\/wp\/v2\/comments?post=6993"}],"version-history":[{"count":0,"href":"https:\/\/doctorhoogstra.com\/pt\/wp-json\/wp\/v2\/wiki\/6993\/revisions"}],"wp:attachment":[{"href":"https:\/\/doctorhoogstra.com\/pt\/wp-json\/wp\/v2\/media?parent=6993"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/pt\/wp-json\/wp\/v2\/categories?post=6993"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/pt\/wp-json\/wp\/v2\/tags?post=6993"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}