{"id":7898,"date":"2020-04-26T07:55:12","date_gmt":"2020-04-26T10:55:12","guid":{"rendered":"https:\/\/doctorhoogstra.com\/es\/dermatitis-herpetiforme-patologia\/"},"modified":"2020-10-30T07:09:49","modified_gmt":"2020-10-30T10:09:49","slug":"dermatitis-herpetiforme-patologia","status":"publish","type":"wiki","link":"https:\/\/doctorhoogstra.com\/pt\/wiki\/dermatitis-herpetiforme-patologia\/","title":{"rendered":"Dermatite patol\u00f3gica herpetiforme"},"content":{"rendered":"<p><\/p><div id=\"ez-toc-container\" class=\"ez-toc-v2_0_89 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Conte\u00fado<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Alternar tabela de conte\u00fado\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Alternar<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 eztoc-toggle-hide-by-default' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/doctorhoogstra.com\/pt\/wiki\/dermatitis-herpetiforme-patologia\/#Histologia-de-dermatitis-herpetiforme\" >Histolog\u00eda de dermatitis herpetiforme<\/a><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/doctorhoogstra.com\/pt\/wiki\/dermatitis-herpetiforme-patologia\/#Dermatitis-herpetiforme-patologia\" >Dermatite patol\u00f3gica herpetiforme<\/a><\/li><\/ul><\/li><\/ul><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/doctorhoogstra.com\/pt\/wiki\/dermatitis-herpetiforme-patologia\/#Variantes-de-dermatitis-herpetiforme\" >Variantes de dermatitis herpetiforme<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/doctorhoogstra.com\/pt\/wiki\/dermatitis-herpetiforme-patologia\/#Manchas-especiales-en-dermatitis-herpetiforme\" >Manchas especiales en dermatitis herpetiforme.<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/doctorhoogstra.com\/pt\/wiki\/dermatitis-herpetiforme-patologia\/#Diagnostico-diferencial-de-dermatitis-herpetiforme\" >Diagn\u00f3stico diferencial de dermatitis herpetiforme<\/a><\/li><\/ul><\/nav><\/div>\n\n<section class=\"textBlock\">\n<h2><span class=\"ez-toc-section\" id=\"Histologia-de-dermatitis-herpetiforme\"><\/span>\n<span class=\"term\" data-term-id=\"128\">Histologia<\/span> do <span class=\"term\" data-term-id=\"53\">dermatite<\/span> herpetiforme<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>El poder de exploraci\u00f3n de la dermatitis herpetiforme muestra <span class=\"term\" data-term-id=\"1029\">vesicular<\/span> patr\u00f3n de reacci\u00f3n (Figura 1), caracterizado por focos o peque\u00f1as zonas de separaci\u00f3n subepid\u00e9rmica (Figuras 2 y 3). Densos racimos de <span class=\"term\" data-term-id=\"196\"><span class=\"term\" data-term-id=\"442\">neutr\u00f3filos<\/span><\/span>  y dispersos <span class=\"term\" data-term-id=\"448\">eosin\u00f3filos<\/span> llenar el papilar <span class=\"term\" data-term-id=\"61\">derme<\/span> formando <span class=\"term\" data-term-id=\"1454\">microabcessos<\/span> (Figura 4). <span class=\"term\" data-term-id=\"1344\">Acantol\u00edtico<\/span> <span class=\"term\" data-term-id=\"1069\">queratin\u00f3citos<\/span> tambi\u00e9n puede ser evidente dentro del papilar <span class=\"term\" data-term-id=\"1453\">microabscess<\/span> (Figura 4). Con el tiempo, las peque\u00f1as \u00e1reas de papilar <span class=\"term\" data-term-id=\"52\">d\u00e9rmico<\/span> la separaci\u00f3n puede unirse para formar \u00e1reas m\u00e1s grandes de vesiculaci\u00f3n.<\/p>\n<section class=\"textBlock imageLinkBlockTitle\">\n<h5 class=\"colour--primary\"><span class=\"ez-toc-section\" id=\"Dermatitis-herpetiforme-patologia\"><\/span>Dermatite patol\u00f3gica herpetiforme<span class=\"ez-toc-section-end\"><\/span><\/h5>\n<\/section>\n<section class=\"imageLinkBlock\">\n<div class=\"flex\">\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='dhfigure1__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisinkildi0xq-6089140-7643384' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/dhfigure1__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsInkiLDI0XQ-6089140.jpg'>\n<\/div>\n<p class=\"p-small\">figura 1<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='dhfigure2__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-8679736-3606566' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/dhfigure2__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-8679736.jpg'>\n<\/div>\n<p class=\"p-small\">Figura 2<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='dhfigure3__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-2009681-1136456' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/dhfigure3__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-2009681.jpg'>\n<\/div>\n<p class=\"p-small\">Figura 3<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='dhfigure4__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-7118472-3420433' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/dhfigure4__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-7118472.jpg'>\n<\/div>\n<p class=\"p-small\">Figura 4<\/p>\n<\/p><\/div>\n<\/section>\n<div class=\"clearfix imageLinkBlock\"><\/div>\n<h2><span class=\"ez-toc-section\" id=\"Variantes-de-dermatitis-herpetiforme\"><\/span>Variantes de dermatitis herpetiforme<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>P\u00e9nfigo herpetiforme: estrictamente una variante del <a href=\"https:\/\/doctorhoogstra.com\/pt\/tipos-tratamientos\/lesoes-de-pele\/\" class=\"wpil_internal_link\" style=\"display: inline !important;width: auto !important\" data-wpil-post-to-id=\"\">p\u00e9nfigo,<\/a> se menciona aqu\u00ed ya que puede presentarse como un imitador cl\u00ednico de la dermatitis herpetiforme. La histolog\u00eda es la del p\u00e9nfigo, t\u00edpicamente de tipo foli\u00e1ceo, con formaci\u00f3n de <span class=\"term\" data-term-id=\"1038\">intraepid\u00e9rmico<\/span> <span class=\"term\" data-term-id=\"1028\">ves\u00edculas<\/span>.<\/p>\n<div id=\"square-placement-country-holder\" class=\"country-dependent advert\">\n<div class=\"box-placement square-placement\">\n<div class=\"advert__frame\">\n<div id=\"dermnet-dermnet-mobbox\">\n<\/div><\/div><\/div><\/div>\n<h2><span class=\"ez-toc-section\" id=\"Manchas-especiales-en-dermatitis-herpetiforme\"><\/span>Manchas especiales en dermatitis herpetiforme.<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Direto <span class=\"term\" data-term-id=\"142\">imunofluoresc\u00eancia<\/span> los estudios muestran dep\u00f3sitos granulares de IgA en la dermis <span class=\"term\" data-term-id=\"374\">papilas<\/span>.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Diagnostico-diferencial-de-dermatitis-herpetiforme\"><\/span>\n<span class=\"term\" data-term-id=\"813\">Diagn\u00f3stico diferencial<\/span> de dermatitis herpetiforme<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>V\u00edrus herpes <span class=\"term\" data-term-id=\"145\">infec\u00e7\u00e3o<\/span>: A pesar de la presencia ocasional de queratinocitos acantol\u00edticos, la dermatitis herpetiforme no muestra <span class=\"term\" data-term-id=\"737\">multinucleaci\u00f3n<\/span>, <span class=\"term\" data-term-id=\"1612\">nuclear<\/span> <span class=\"term\" data-term-id=\"1528\">cromatina<\/span> cambios o <span class=\"term\" data-term-id=\"956\">celular<\/span> <span class=\"term\" data-term-id=\"1832\">inclus\u00f5es<\/span>.<\/p>\n<p><span class=\"term\" data-term-id=\"321\">Linear<\/span> IgA <span class=\"term\" data-term-id=\"498\">bolhoso<\/span> <span class=\"term\" data-term-id=\"60\">doen\u00e7a de pele<\/span>: Los <span class=\"term\" data-term-id=\"474\">histol\u00f3gico<\/span> aunque los hallazgos son en gran medida id\u00e9nticos <span class=\"term\" data-term-id=\"3\">acant\u00f3lise<\/span> e <span class=\"term\" data-term-id=\"850\">fibrina<\/span> en las puntas de las papilas d\u00e9rmicas y <span class=\"term\" data-term-id=\"1386\">leucocitose<\/span> Es m\u00e1s frecuente en dermatitis herpetiforme. Los resultados de la inmunofluorescencia mostrar\u00e1n una tinci\u00f3n lineal de la membrana basal de IgA.<\/p>\n<p>Lupus eritematoso ampolloso: la histolog\u00eda puede ser id\u00e9ntica a la discriminaci\u00f3n solo posible cuando se encuentran IgG e IgM lineales en la membrana basal. Los dep\u00f3sitos de IgA tambi\u00e9n se pueden ver simult\u00e1neamente. Con frecuencia el papilar d\u00e9rmico <span class=\"term\" data-term-id=\"443\">neutrof\u00edlico<\/span> <span class=\"term\" data-term-id=\"541\">infiltrar<\/span> se ve que se extiende hacia los alrededores <span class=\"term\" data-term-id=\"693\">interst\u00edcio<\/span>.<\/p>\n<p><span class=\"term\" data-term-id=\"36\">Cicatricial<\/span> penfigoide: en lesiones tempranas papilares <span class=\"term\" data-term-id=\"1\">abscesso<\/span> se puede ver la formaci\u00f3n, aunque la <span class=\"term\" data-term-id=\"449\">eosinof\u00edlico<\/span> la poblaci\u00f3n aumenta con <span class=\"term\" data-term-id=\"164\">ferimentos<\/span> hora. La caracter\u00edstica distintiva clave es la presencia de cicatrices d\u00e9rmicas debajo de la ampolla. La inmunofluorescencia tambi\u00e9n difiere con la IgG lineal que se ve t\u00edpicamente en la membrana basal. Casos excepcionales pueden mostrar IgA <span class=\"term\" data-term-id=\"370\">declara\u00e7\u00e3o<\/span> solo.<\/p>\n<\/section>","protected":false},"excerpt":{"rendered":"<p>Histolog\u00eda de dermatitis herpetiforme El poder de exploraci\u00f3n de la dermatitis herpetiforme muestra vesicular patr\u00f3n de reacci\u00f3n (Figura 1), caracterizado por focos o peque\u00f1as zonas de separaci\u00f3n subepid\u00e9rmica (Figuras 2&#8230;<\/p>","protected":false},"author":8,"featured_media":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","format":"standard","meta":{"footnotes":""},"categories":[204],"tags":[205],"class_list":["post-7898","wiki","type-wiki","status-publish","format-standard","category-glosario-definiciones","tag-patologia"],"_links":{"self":[{"href":"https:\/\/doctorhoogstra.com\/pt\/wp-json\/wp\/v2\/wiki\/7898","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/doctorhoogstra.com\/pt\/wp-json\/wp\/v2\/wiki"}],"about":[{"href":"https:\/\/doctorhoogstra.com\/pt\/wp-json\/wp\/v2\/types\/wiki"}],"author":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/pt\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/pt\/wp-json\/wp\/v2\/comments?post=7898"}],"version-history":[{"count":0,"href":"https:\/\/doctorhoogstra.com\/pt\/wp-json\/wp\/v2\/wiki\/7898\/revisions"}],"wp:attachment":[{"href":"https:\/\/doctorhoogstra.com\/pt\/wp-json\/wp\/v2\/media?parent=7898"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/pt\/wp-json\/wp\/v2\/categories?post=7898"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/pt\/wp-json\/wp\/v2\/tags?post=7898"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}