{"id":8123,"date":"2020-04-27T06:36:32","date_gmt":"2020-04-27T09:36:32","guid":{"rendered":"https:\/\/doctorhoogstra.com\/es\/patologia-de-la-enfermedad-de-paget-extramamaria\/"},"modified":"2020-04-30T21:08:57","modified_gmt":"2020-05-01T00:08:57","slug":"patologia-extramamaria-paget-doenca","status":"publish","type":"wiki","link":"https:\/\/doctorhoogstra.com\/pt\/wiki\/patologia-de-la-enfermedad-de-paget-extramamaria\/","title":{"rendered":"Patologia da doen\u00e7a de Paget extramam\u00e1ria"},"content":{"rendered":"<p><\/p><div id=\"ez-toc-container\" class=\"ez-toc-v2_0_88 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Conte\u00fado<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Alternar tabela de conte\u00fado\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Alternar<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 eztoc-toggle-hide-by-default' ><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/doctorhoogstra.com\/pt\/wiki\/patologia-de-la-enfermedad-de-paget-extramamaria\/#Cancer-de-piel\" >C\u00e2ncer de pele<\/a><\/li><\/ul><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/doctorhoogstra.com\/pt\/wiki\/patologia-de-la-enfermedad-de-paget-extramamaria\/#Introduccion\" >Introdu\u00e7\u00e3o<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/doctorhoogstra.com\/pt\/wiki\/patologia-de-la-enfermedad-de-paget-extramamaria\/#Histologia-de-la-enfermedad-de-Paget-extramamaria\" >Histologia da doen\u00e7a de Paget extramam\u00e1ria<\/a><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/doctorhoogstra.com\/pt\/wiki\/patologia-de-la-enfermedad-de-paget-extramamaria\/#Patologia-de-la-enfermedad-de-Paget-extramamaria\" >Patologia da doen\u00e7a de Paget extramam\u00e1ria<\/a><\/li><\/ul><\/li><\/ul><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/doctorhoogstra.com\/pt\/wiki\/patologia-de-la-enfermedad-de-paget-extramamaria\/#Estudios-especiales-de-la-enfermedad-de-Paget-extramamaria\" >Estudos especiais da doen\u00e7a de Paget extramam\u00e1ria<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/doctorhoogstra.com\/pt\/wiki\/patologia-de-la-enfermedad-de-paget-extramamaria\/#Diagnostico-diferencial-de-la-enfermedad-de-Paget-extramamaria\" >Diagn\u00f3stico diferencial da doen\u00e7a de Paget extramam\u00e1ria<\/a><\/li><\/ul><\/nav><\/div>\n\n<section class=\"textBlock\">\n<div class=\"cmsBlock\">\n<div class=\"cmsBlock__shortcode\">\n<section class=\"textBlock\">\n<p><img alt='Voc\u00ea est\u00e1 em: P\u00e1gina Inicial&gt; Imprensa&gt; Not\u00edcias' class=\"right\" title=\"\" src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/miiskin-3-2-133__ScaleWidthWzEwMF0-8268734.jpg' width=\"100\" height=\"100\"><\/p>\n<blockquote>\n<p style=\"text-align: center\"><em>de An\u00fancios<\/em><\/p>\n<h4><span class=\"ez-toc-section\" id=\"Cancer-de-piel\"><\/span>C\u00e2ncer de pele<span class=\"ez-toc-section-end\"><\/span><\/h4>\n<p><strong>Aplicativo para facilitar o auto-exame da pele e a detec\u00e7\u00e3o precoce<\/strong>. <strong><span style=\"text-decoration: underline\">consulte Mais informa\u00e7\u00e3o<\/span>.<\/strong><\/p>\n<\/blockquote>\n<\/section>\n<div class=\"clearfix\"><\/div>\n<\/div>\n<div class=\"cmsBlock__title\">Texto: Miiskin.<\/div>\n<\/div>\n<h2><span class=\"ez-toc-section\" id=\"Introduccion\"><\/span>Introdu\u00e7\u00e3o<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>A doen\u00e7a extramam\u00e1ria da pele de Paget \u00e9 uma <span class=\"term\" data-term-id=\"1742\">malignidade<\/span>associada a doen\u00e7a de pele caracterizada por <span class=\"term\" data-term-id=\"492\">eczematoso<\/span> <span class=\"term\" data-term-id=\"255\">erup\u00e7\u00e3o<\/span> do <span class=\"term\" data-term-id=\"825\">anogenital<\/span> regi\u00e3o e <span class=\"term\" data-term-id=\"1004\">vulva<\/span>onde h\u00e1 uma abund\u00e2ncia de <span class=\"term\" data-term-id=\"12\">gl\u00e2ndulas ap\u00f3crinas<\/span>. <span class=\"term\" data-term-id=\"949\">Prim\u00e1rio<\/span> <span class=\"term\" data-term-id=\"47\">cut\u00e2neo<\/span> existem formas associadas a subjacentes <span class=\"term\" data-term-id=\"1827\">em anexo<\/span> <span class=\"term\" data-term-id=\"32\">carcinoma<\/span>, al\u00e9m das formas associadas ao adenocarcinoma anal, retal ou da bexiga subjacente. A doen\u00e7a extramam\u00e1ria de Paget pode preceder a malignidade associada em at\u00e9 15 anos.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Histologia-de-la-enfermedad-de-Paget-extramamaria\"><\/span>\n<span class=\"term\" data-term-id=\"128\">Histologia<\/span> da doen\u00e7a de Paget extramam\u00e1ria<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Paget <span class=\"term\" data-term-id=\"289\">tumor<\/span> c\u00e9lulas est\u00e3o no <span class=\"term\" data-term-id=\"85\">epiderme<\/span> (Figura 1-3). Raramente, as c\u00e9lulas tumorais podem se espalhar para o <span class=\"term\" data-term-id=\"61\">derme<\/span>. Em les\u00f5es anteriores, as c\u00e9lulas de Paget est\u00e3o localizadas perto da membrana basal e se espalham para preencher toda a epiderme \u00e0 medida que a condi\u00e7\u00e3o progride. As c\u00e9lulas tumorais s\u00e3o grandes, com <span class=\"term\" data-term-id=\"449\">eosinof\u00edlico<\/span> <span class=\"term\" data-term-id=\"838\">citoplasma<\/span>, grande <span class=\"term\" data-term-id=\"1540\">pleom\u00f3rfico<\/span> <span class=\"term\" data-term-id=\"729\">n\u00facleos<\/span> e ocasional <span class=\"term\" data-term-id=\"1535\">mitose<\/span> (Figura 3). <span class=\"term\" data-term-id=\"610\">Hiperqueratose<\/span> e <span class=\"term\" data-term-id=\"218\">paraqueratose<\/span> pode se sobrepor <span class=\"term\" data-term-id=\"1449\">agregados<\/span> de c\u00e9lulas tumorais (Figura 2). <span class=\"term\" data-term-id=\"136\">Hiperplasia<\/span> da epiderme pode ser <span class=\"term\" data-term-id=\"270\">escamoso<\/span>, <span class=\"term\" data-term-id=\"216\">papilomatoso<\/span> ou <span class=\"term\" data-term-id=\"1652\">fibroepitelioma<\/span> de Pinkus. <span class=\"term\" data-term-id=\"1278\">Ulcera\u00e7\u00e3o<\/span> e <span class=\"term\" data-term-id=\"1521\">pigmenta\u00e7\u00e3o<\/span> pode estar presente. <span class=\"term\" data-term-id=\"52\">D\u00e9rmica<\/span> mudan\u00e7as incluem um <span class=\"term\" data-term-id=\"319\">cr\u00f4nica<\/span> <span class=\"term\" data-term-id=\"490\">inflamat\u00f3rio<\/span> <span class=\"term\" data-term-id=\"541\">infiltrar<\/span> (Figura 1, 2). Um carcinoma anexial subjacente pode estar presente.<\/p>\n<section class=\"textBlock imageLinkBlockTitle\">\n<h5 class=\"colour--primary\"><span class=\"ez-toc-section\" id=\"Patologia-de-la-enfermedad-de-Paget-extramamaria\"><\/span>Patologia da doen\u00e7a de Paget extramam\u00e1ria<span class=\"ez-toc-section-end\"><\/span><\/h5>\n<\/section>\n<section class=\"imageLinkBlock\">\n<div class=\"flex\">\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='pagetsfigure1__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-1345494-4410927' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/pagetsfigure1__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-1345494.jpg'>\n<\/div>\n<p class=\"p-small\">figura 1<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='pagetsfigure2__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-1837460-4462802' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/pagetsfigure2__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-1837460.jpg'>\n<\/div>\n<p class=\"p-small\">Figura 2<\/p>\n<div class=\"imageLinkBlock__item__image\">\n<p>                        <img alt='pagetsfigure3__protectwyjqcm90zwn0il0_focusfillwzi5ncwymjisingildfd-1089725-2402696' src='https:\/\/doctorhoogstra.com\/wp-content\/uploads\/2020\/04\/pagetsfigure3__ProtectWyJQcm90ZWN0Il0_FocusFillWzI5NCwyMjIsIngiLDFd-1089725.jpg'>\n<\/div>\n<p class=\"p-small\">Figura 3<\/p>\n<\/p><\/div>\n<\/section>\n<div class=\"clearfix imageLinkBlock\"><\/div>\n<div id=\"square-placement-country-holder\" class=\"country-dependent advert\"><\/div>\n<h2><span class=\"ez-toc-section\" id=\"Estudios-especiales-de-la-enfermedad-de-Paget-extramamaria\"><\/span>Estudos especiais da doen\u00e7a de Paget extramam\u00e1ria<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>As c\u00e9lulas tumorais cont\u00eam abundantes <span class=\"term\" data-term-id=\"1636\">mucina<\/span> que pode ser identificado pela colora\u00e7\u00e3o com azul de Alcian e \u00e1cido Schiff peri\u00f3dico (PAS). Imuno-histoquimicamente, as c\u00e9lulas de Paget <span class=\"term\" data-term-id=\"847\">epitelial<\/span> membrana <span class=\"term\" data-term-id=\"410\">ant\u00edgeno<\/span> (EMA), baixo <span class=\"term\" data-term-id=\"1851\">molecular<\/span> peso <span class=\"term\" data-term-id=\"1613\">citoqueratinas<\/span> (CK7 +) e CD23 com positividade vari\u00e1vel para o ant\u00edgeno carcinoembrion\u00e1rio (CEA). As citoqueratinas de alto peso molecular mancham a epiderme circundante e real\u00e7am as c\u00e9lulas Paget negativas.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Diagnostico-diferencial-de-la-enfermedad-de-Paget-extramamaria\"><\/span>\n<span class=\"term\" data-term-id=\"813\">Diagn\u00f3stico diferencial<\/span> da doen\u00e7a de Paget extramam\u00e1ria<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Doen\u00e7a de Paget na pele - esta condi\u00e7\u00e3o \u00e9 a pele <span class=\"term\" data-term-id=\"164\">ferimentos<\/span> que surge de um ducto subjacente <span class=\"term\" data-term-id=\"1077\">no lugar<\/span> carcinoma da mama. A doen\u00e7a extra-mam\u00e1ria de Paget n\u00e3o possui a express\u00e3o Her-2 \/ neu observada na doen\u00e7a mam\u00e1ria de Paget. Tumores de mama e tumores origin\u00e1rios das gl\u00e2ndulas ap\u00f3crinas s\u00e3o corados com GCDFP-15.<\/p>\n<p><span class=\"term\" data-term-id=\"1670\">Melanoma<\/span> <span class=\"term\" data-term-id=\"863\">no lugar<\/span> - ao contr\u00e1rio de Paget, o melanoma \u00e9 negativo para citoqueratinas, EMA e CEA. S100, HMB-45 e MART-1 s\u00e3o geralmente negativos na doen\u00e7a de Paget e positivos no melanoma.<\/p>\n<p>Carcinoma de c\u00e9lulas escamosas (SCC) in situ (<span class=\"term\" data-term-id=\"1038\">intraepid\u00e9rmico<\/span> carcinoma) - P63 \u00e9 positivo no CEC in situ, diferente de Paget. <span class=\"term\" data-term-id=\"1614\">Citoqueratina<\/span> sete podem ser positivos no Paget e no SCC no local.<\/p>\n<p><span class=\"term\" data-term-id=\"262\">Seb\u00e1ceo<\/span> carcinoma in situ - adipofilina positivo, CEA negativo, GCDFP-15 negativo.<\/p>\n<\/section>","protected":false},"excerpt":{"rendered":"<p>Anuncio C\u00e1ncer de piel Aplicaci\u00f3n para facilitar el autoexamen de la piel y la detecci\u00f3n temprana. Lee mas. Texto: Miiskin. Introducci\u00f3n La enfermedad de Paget extramamaria de la piel es&#8230;<\/p>","protected":false},"author":8,"featured_media":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","format":"standard","meta":{"footnotes":""},"categories":[204],"tags":[205],"class_list":["post-8123","wiki","type-wiki","status-publish","format-standard","category-glosario-definiciones","tag-patologia"],"_links":{"self":[{"href":"https:\/\/doctorhoogstra.com\/pt\/wp-json\/wp\/v2\/wiki\/8123","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/doctorhoogstra.com\/pt\/wp-json\/wp\/v2\/wiki"}],"about":[{"href":"https:\/\/doctorhoogstra.com\/pt\/wp-json\/wp\/v2\/types\/wiki"}],"author":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/pt\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/doctorhoogstra.com\/pt\/wp-json\/wp\/v2\/comments?post=8123"}],"version-history":[{"count":0,"href":"https:\/\/doctorhoogstra.com\/pt\/wp-json\/wp\/v2\/wiki\/8123\/revisions"}],"wp:attachment":[{"href":"https:\/\/doctorhoogstra.com\/pt\/wp-json\/wp\/v2\/media?parent=8123"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/pt\/wp-json\/wp\/v2\/categories?post=8123"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/doctorhoogstra.com\/pt\/wp-json\/wp\/v2\/tags?post=8123"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}