Diethylthiourea allergy

What is diethylthiourea and where can it be found?

Diethylthiourea is part of the allergen group called dialkyl mixed thioureas. The other thiourea included in this group is dibutylthiourea.

Thiourea derivatives are added to neoprene rubber products such as diving wetsuits, rubber weather stripping, neoprene rubber gloves, orthopedic knee and elbow pads, swimming goggles, fishing boots, athletic shoe insoles, and keyboard wrist supports. Adding diethylthiourea speeds up the vulcanization of neoprene rubber, making the rubber more stable, stronger, and more flexible so it can be molded and shaped into different products. Industrial uses of diethylthiourea are in anti-corrosion compounds, detergents, fungicides and insecticides, some polyvinyl chloride adhesives, and in diazo copy paper used for industrial textile patterns and architectural plans.

Mixed Diakyl Thioureas Named Contact Allergen of the Year for 2009 by US Contact Dermatitis Society (ACDS).

What are the reactions to diethylthiourea? allergy?

In people allergic to diethylthiourea, contact with diethylthiourea produces classic allergic contact dermatitis.

Dermatitis is generally limited to the area of the neoprene rubber product. For example, in two reported cases of occupational allergic contact dermatitis from car handle padding made of neoprene rubber, both patients had vesicular dermatitis on your palms, fingers, and wrists. However, footwear is the most common source of diethylthiourea allergy, while gloves are the most common occupational source.

Am I allergic to diethylthiourea?

Allergy to diethylthiourea is diagnosed by performing special allergy tests, i.e. patch tests Concentrations of 1.0% diethylthiourea in Vaseline can be used for patch testing.

The number of cases of contact allergy to diethylthiourea reported in the literature is relatively small. Targeted diethylthiourea patch tests and retrospective analysis have shown that patients with a history of neoprene rubber dermatitis react strongly and positively to diethylthiourea to 1%.

Treatment of allergy to diethylthiourea

Confirmation of allergy to diethylthiourea requires removal of the causative agent and then management as for any acute dermatitis/eczema; this may include treatment with current corticosteroids and emollients.

What should I do to avoid allergy to diethylthiourea?

Patients with an allergy to diethylthiourea should avoid contact with neoprene rubber products. You dermatologist You may have more specific advice, especially if you are very sensitive to diethylthiourea.

Alternative names for diethylthiourea

• 1,3-diethyl-2-thiourea
• 1,3-diethylthiourea
• N,N′-Diethylthiocarbamide
• N,N′-Diethylthiourea
• Accel USD
• Pennzone E
• EUR
• Thiate H.
• u 15030
• Thiourea

More information

Formula: C_{5 5}H₁₂north₂S

CAS number: 105-55-5

Cross reactions:

Appearance: white solid

Sensitizer: diethylthiourea

Patch Test: Diethylthiourea 1.0% in Vaseline