Angiofibroma pathology

Introduction

There are numerous different clinical forms of angiofibromas they share an identical histopathology:

• Fibrous papule
• Pearl penis papules
• adenoma sebaceous (facial angiofibomas associated with tuberoses sclerosis)
• Syndromic angiofibroma

Histology angiofibroma

Angiofibromas cause a dome-shaped mass on the surface dermis (Figure 1). The overlying epidermis not involved but it can be atrophic. the injury is characterized by a proliferation of starry cells and spiral around blood vessels (Figure 2). There is thick concentric collagen packages (figures 1, 2). Comparison of the collagen density of the lesion with the surrounding dermis, which should be looser or elastotically damaged, may be a useful diagnostic clue. Occasionally a scant inflammatory cell infiltrate of lymphocytes is present.

Various histological Subtypes have been described:

• Hypercellular angiofibroma is characterized by a greater number of stellate and spindle-shaped cells (Figure 3).
• Clear cell angofibroma shows a proliferation of granular to foamy cells that resembles histiocytes.
• Pleomorphic angiofibroma is characterized by strange, starry fibroblasts.
• A epithelioid The angiofibroma variant consists of epithelioid-like cells with rose cytoplasm and prominent nucleoli.

Special studies for angiofibroma.

Dermal dendritic cells it is generally stained for factor XIIIa. S100 is negative.

Differential diagnosis angiofibroma pathology

Sclerosing nevus - These generally do not exhibit vascular ectasia The stain S100 will highlight the melanocytes, and will be negative in fibrous papules.

Capillary hemangioma - These lack the fibrous stroma with stellate fibroblasts and dense collagen.