Circumscribed palmar hypokeratosis

What is it circumscribed palm hypokeratosis?

Circumscribed palmar hypokeratosis is a rare, persistent, solitary, red patch thin skin on the hand.

Who gets circumscribed palmar hypokeratosis?

To date, about 50 cases of circumscribed palmar hypokeratosis have been described in the medical literature. It predominantly affects women in the fourth to seventh decade of life. A congenital The case has been described.

What causes circumscribed palmar hypokeratosis?

The cause of circumscribed palmar hypokeratosis is unknown.

• One case reported an association with human papillomavirus (HPV) type 4, which is a cause of viral warts, but the significance of this finding is unclear.
• A located waste of cellular accession possible, causing abrupt loss or detachment of the stratum corneum layer epidermis.
• Abnormal keratinization or abnormal keratinocytes differentiation They have also been implicated.
• A couple of cases have been associated with trauma (and were called “palmar pseudo circumscribed /plant hypokeratosis).

What are the clinical characteristics of circumscribed palmar hypokeratosis?

Circumscribed palmar hypokeratosis occurs most frequently on the thenar or hypothenar eminence of the palm, the sole of the foot (plantar aspect), or less frequently the palmar aspect of the fingers. Very rarely, it may affect the skin on the back of the fingers or not.acral skin sites. There are some reports of cases with more than one. injury which affects both the palms or palms and the fingers or palms and soles of the feet.

Circumscribed palmar hypokeratosis has a thin pink central area atrophicsoft or slightly scaly skin, while at the edge there is an abrupt transition to normal skin.

How is circumscribed palmar hypokeratosis diagnosed?

Circumscribed palmar hypokeratosis can be diagnosed on its distinctive clinical appearance.

A biopsy can be taken across the edge of a lesion. This shows that the epidermis in the central area of the affected skin lacks stratum corneum (horny layer) At the edge of the lesion there is a very sharp abrupt transition to the normal compact orthohypekeratosis, typical of the palmar skin. They do not exist histological findings suggestive of HPV infection.

The main differential diagnoses to consider in circumscribed palmar hypokeratosis are porokeratosis and scaly cell carcinoma in the place.

What is the treatment of circumscribed palmar hypokeratosis?

No treatment is required for circumscribed palmar hypokeratosis. However:

• Regular application of current calcipotriol (calcipotriene) 0.05% cream It can flatten the sharp cut at the edge of the lesion, leaving a thin, flat, pink patch of skin.
• 5-Fluorouracil cream, cryotherapy and photodynamic Therapy (PDT) has been reported to be partially effective in individual cases.

What is the result of circumscribed palmar hypokeratosis?

Circumscribed palmar hypokeratosis is a chronic condition that persists unchanged over time or that may enlarge very slowly. There are no reports of Cancer developing within the lesions.