Inflammatory lesions in acne.

What are they inflammatory acne lesions?

Inflammatory lesions in acne include small red bumps (papules), pustules, large red bumps (nodules) and pseudocysts (these are fluctuating nodules) Inflammatory acne lesions are often painful.

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• Facial acne
• Back acne

What is the cause of inflamed acne? injury?

An inflamed lesion usually follows wall rupture of a closed wall. comedo. It can also arise from normal-looking skin.

Inflammation follows immune activation in and around the pilosebaceous unit (hair follicle and sebaceous gland). Factors that contribute to inflammation include:

• free fatty acids and tallow, which penetrate the dermis after the duct has ruptured and must be removed
• Chemicals produced by acne. bacteria such as Cutibacterium acnes, which diffuse in the surrounding skin (dermis)
• Proinflammatory mediators (IL-1a, IL-b, TNF) produced by the cells that line the sebaceous ducts, that is, the innate immune system
• Debris inside the follicles, which can induce a more serious granulomatous inflammatory reaction through macrophages and giant cells
• Hypersensitivity or excessive immune reaction to P. acnes, the presumed cause of the most severe form of acne, acne fulminans.