Leiner's disease

What is Leiner's disease?

Leiner's disease occurs in babies and is characterized by severe illness. generalized seborrheic dermatitis, recurrent diarrhea, recurrent skin and internal infections and lack of growth. Also known as erythroderma desquamativum Leiner's disease may be present at birth, but it most commonly develops in the first months of life. It appears to be more common in women than in men and infants.

What causes Leiner's disease?

The precise cause of Leiner's disease remains unknown, but there is a known defect in the body. complement The system has an important role to play in its development. The complement system is a vital part of the body's immune system, and in Leiner's disease, an inherited system dysfunction or deficiency in the C5 component of complement along with other factors have been implicated. Other immune deficiencies can present identically in childhood.

What are the signs and symptoms?

The condition generally begins as a scaly eruption on the scalp, face, or napkin area. It very quickly spreads to other parts of the body. The affected area is bright red and may look swollen. Babies seem uncomfortable but don't sting. Other symptoms include recurrent diarrhea, babies who are not thriving or gaining weight, and local skin infections. There is also a risk of developing more serious infections that can lead to pneumonia, meningitis and septicemia.

What treatment is available?

Initially affected babies may need hospitalization to control heat and fluid loss. Friendly emollients It can be used to treat the rash. Providing proper nutrition is also an essential part of treatment.

Biotin, a water-soluble vitamin naturally found in foods such as liver, kidney, meat, milk, egg yolks, and vegetables, appears to be helpful in treating Leiner's disease.